Author(s): Roshan Kumar Jha, Ranjit S. Ambad, Priya Koundal, Akansha Singh

Email(s): Ambad.sawan@gmail.com

DOI: 10.52711/0974-360X.2021.00865   

Address: Roshan Kumar Jha1, Dr. Ranjit S. Ambad2*, Priya Koundal3, Akansha Singh4
1Tutor, Dept. of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, Maharashtra – 442001.
2Associate Professor, Dept. of Biochemistry, Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Wanadongri, Hingana, Nagpur – 441110.
3Tutor Dept. of Biochemistry, DUPMH, Jalgaon, Maharashtra.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
It has been proved that tobacco is one of the cholesterol dependent risk factors pathogenically, and in addition with other risk factors it may lead to coronary heart disease. Thus, a strong interaction exists between hypercholesterolemia and tobacco ingesting in the genesis of coronary heart disease. The aim of this study was to study the effect of tobacco smoking and chewing and compare its effect on lipoproteins. 60 subjects were included in the study, and were grouped into 3 three groups, tobacco smokers, tobacco chewers and tobacco non-abusers. Each group comprises 20 participants: selected on the basis of inclusion and exclusion criteria. Proper sampling and sample processing methods were employed to evaluate lipid profile. Total cholesterol and triglycerides levels were increased in smokers in comparison to non-smokers/non-chewers, and the differences were significant p<0.0001. HDL level was decreased in smokers as compared to non-smokers/non-chewers and the difference was statistically significant p<0.0001. Total cholesterol and LDL levels were increased in smokers in comparison to chewers. HDL level was decreased in chewers as compared to chewers. There was no significant association in any of the parameters. Present study observed increased and significant p<0.0001 differences in levels of total cholesterol and triglycerides while, HDL levels were decreased significantly p<0.0001, and also observed there was no significant difference among tobacco smokers and chewers. This may be a new area of interest for future studies.


Cite this article:
Roshan Kumar Jha, Ranjit S. Ambad, Priya Koundal, Akansha Singh. Effect of Tobacco on Lipoprotein Profile: A Comparative study among Smokers and Chewers. Research Journal of Pharmacy and Technology. 2021; 14(9):4973-6. doi: 10.52711/0974-360X.2021.00865

Cite(Electronic):
Roshan Kumar Jha, Ranjit S. Ambad, Priya Koundal, Akansha Singh. Effect of Tobacco on Lipoprotein Profile: A Comparative study among Smokers and Chewers. Research Journal of Pharmacy and Technology. 2021; 14(9):4973-6. doi: 10.52711/0974-360X.2021.00865   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-79


REFERENCE:
1.    Gadpal, R.R., Deshpande, K.A. and Waghmare, M.H., 2015. A study of lipid profile in tobacco chewers and smokers. J Contemp Med Dent, 3, pp.39-43.
2.    Bulliyya, G., 2002. Blood pressure and serum lipid profile in smokers and non-smokers-A comparative study. The Indian Practitioner, 55(6), pp.363-8.
3.    Rani, M., Bonu, S., Jha, P., Nguyen, S.N. and Jamjoum, L., 2003. Tobacco use in India: prevalence and predictors of smoking and chewing in a national cross sectional household survey. Tobacco control, 12(4), pp.e4-e4.
4.    Batic-Mujanovic, O., Beganlic, A., Salihefendic, N., Pranjic, N. and Kusljugic, Z., 2008. Influence of smoking on serum lipid and lipoprotein levels among family medicine patients. Med Arh, 62(5-6), pp.264-267.
5.    Neki, N.S., 2002. Lipid profile in chronic smokers–A clinical study. Journal, Indian academy of clinical medicine, 3(1): 51-4.
6.    Ch, S.R., 2013. The effect of chronic tobacco smoking and chewing on the lipid profile. Journal of clinical and diagnostic research: JCDR, 7(1): 31.
7.    Jha, R. K., Mahajan, S., Mehta, D., Ambad, R. S., and Koundal, P. (2020). To Estimate Lipid Profile in Patients with Copd. International Journal of Medical and Biomedical Studies, 4(1).
8.    Roeschlau P, Brent E, Gruber W. Enzymatic determination of total cholesterol in serum. Clin Chem Clin Biochem. 1974; 12(226).
9.    Product data sheet, Triglyceride-G Code No 997-69801, Wako pure Chemical Industries Ltd. Dallas TX.
10.    Mc Gowan MW, Artiss JD, Strandbergh DR. A Peroxidase coupled method for the colorimetric determination of serum triglycerides. Clin Chem. 1983; 29(3): 538-42.
11.    Fossati P, Principle L. Serum triglycerides are determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982; 28; 2077-80.
12.    Stamford, B.A., Matter, S., Fell, R.D., Sady, S., Papanek, P. and Cresanta, M., 1984. Cigarette smoking, exercise and high density lipoprotein cholesterol. Atherosclerosis, 52(1), 73-83.
13.    Garrison, R.J., Kannel, W.B., Feinleib, M., Castelli, W.P., McNamara, P.M. and Padgett, S.J., 1978. Cigarette smoking and HDL cholesterol the Framingham offspring study. Atherosclerosis, 30(1): 17-25.
14.    Johnkennedy, N., 2010. Effect of smoking on lipid profile among adult smokers in Owerri, Nigeria. Journal of Medical Laboratory Science, 1(2).
15.     Yadav, B.K., Bade, A.R., Singh, J. and Jha, B., 2005. Comparative study of lipid profile in smokers, tobacco chewers and diabetic patients. Journal of Institute of Medicine, 27(3): 38-41.
16.    Guedes, D.P., Barbosa, D.S. and Oliveira, J., 2007. profile in adolescents. Rev Assoc Med Bras, 53(1): 59-63.
17.    Saengdith, P., 2008. Effects of cigarette smoking on serum lipids among priests in Bangkok. J Med Assoc Thai, 91(1): pp.S41-4.
18.    Ch, S.R., 2013. The effect of chronic tobacco smoking and chewing on the lipid profile. Journal of clinical and diagnostic research: JCDR, 7(1): 31.
19.    Khurana M, Sharma D, Khandelwal PD. Lipid profile in smokers and tobacco chewers--a comparative study. The Journal of the Association of Physicians of India. 2000; 48(9): 895-7
20.    Latha, M.S., Vijayammal, P.L. and Kurup, P.A., 1993. Effect of nicotine administration on lipid metabolism in rats. The Indian journal of medical research, 98, pp.44-49.
21.    Deolia, S., S. Agarwal, K.G. Chhabra, G. Daphle, S. Sen, and A. Jaiswal. “Physical and Psychological Dependence of Smokeless and Smoked Tobacco.” Journal of Clinical and Diagnostic Research 12, no. 3 (2018): ZC01–4.
22.    Goyal A, Sharma A, Agarwal S, Bhansali S, Chhabra KG, Chhabra C. Determinants of Tobacco use among children of a rural village in India: An exploratory qualitative study. Asian Pac J Cancer Preven 2020; 21(1): 81-86.
23.    Smrutipragnya S, Priyanka D, Santosh Kumar S. Role of Chromium Enriched Tobacco in the Occurrence of Oral Carcinogenesis. Int J Cur Res Rev. 2020; 12(18): 20-24.
24.    Ajay Meshram, Komal Meshram, Ranjeet Ambad, Karuna Kacchua, Lata Kanyal, Shilpa Ingle, Angali Vagga, Roshan Kumar Jha. Vit D Status and Osteoporosis in Tobacco Consuming Men in Rural Region Surrounding Wardha City, Maharashtra, Central Part of India. Indian Journal of Forensic Medicine and Toxicology, 2020; 14(4): 6737-6742.
25.    Ajonish Kamble, Ranjit S. Ambad, Mangesh Padamwar, Anupam Kakade, Meenakshi Yeola. To study the effect of oral vitamin D supplements on wound healing in patient with diabetic foot ulcer and its effect on lipid metabolism. Int. J. Res. Pharm. Sci., 2020; 11(2): 2701-2706.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available