Author(s): Annise Proboningrat, Shara Jayanti, Amaq Fadholly, Arif N. M. Ansori, Naimah Putri, Muhammad K. J. Kusala, Sri A. Sudjarwo, Fedik A. Rantam, Agung Budianto Achmad

Email(s): annise.drh@gmail.com

DOI: 10.52711/0974-360X.2021.00864   

Address: Annise Proboningrat1*, Shara Jayanti2, Amaq Fadholly1,3, Arif N. M. Ansori1, Naimah Putri1, Muhammad K. J. Kusala1, Sri A. Sudjarwo4, Fedik A. Rantam5,6, Agung Budianto Achmad7
1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
2Study Program of Fishery Pathology Management Techniques, Marine and Fisheries Polytechnic, Sidoarjo, 61253, Indonesia.
3Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah, Purwokerto, 53182, Indonesia.
4Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
5Department of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
6Research Center for Vaccine Technology and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia.
7Department of Health, Faculty of Vocational Studies, Universitas Airlang

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Cancer is a significant global health problem today and responsible for most deaths after cardiovascular diseases. One of the conventional modalities for cancer treatment is chemotherapy. However, it has many side effects and complications. Therefore, the search for novel drug candidates from natural ingredients that are more effective and have minimal side effects is critical. This study is aimed to determine the cytotoxic effect of Allium cepa L. extract on human cervical cancer cells. The cytotoxicity test procedure was performed using MTT assay against HeLa cells. The result revealed that Allium cepa L. ethanolic extract has a weak cytotoxic effect on HeLa cells with IC50 of 900.88 µg/ml. Further research into Allium cepa L. is required to isolate and identify its components and determine their potential as new agents against HeLa cells.


Cite this article:
Annise Proboningrat, Shara Jayanti, Amaq Fadholly, Arif N. M. Ansori, Naimah Putri, Muhammad K. J. Kusala, Sri A. Sudjarwo, Fedik A. Rantam, Agung Budianto Achmad. The Cytotoxicity of Ethanolic Extract of Allium cepa L. on Hela Cell Lines. Research Journal of Pharmacy and Technology. 2021; 14(9):4969-2. doi: 10.52711/0974-360X.2021.00864

Cite(Electronic):
Annise Proboningrat, Shara Jayanti, Amaq Fadholly, Arif N. M. Ansori, Naimah Putri, Muhammad K. J. Kusala, Sri A. Sudjarwo, Fedik A. Rantam, Agung Budianto Achmad. The Cytotoxicity of Ethanolic Extract of Allium cepa L. on Hela Cell Lines. Research Journal of Pharmacy and Technology. 2021; 14(9):4969-2. doi: 10.52711/0974-360X.2021.00864   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-78


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