Author(s): A. Anto Arockia Raj, J. Vinnarasi

Email(s): aanto.chemistry@gmail.com , vinnisky@gmail.com

DOI: 10.52711/0974-360X.2021.00854   

Address: A. Anto Arockia Raj1*, J. Vinnarasi2
1Department of Chemistry, St. Xavier’s College (Autonomous), Palayamkottai, Tamil Nadu, India – 627002.
2Department of Chemistry, The Standard Fireworks Rajaratnam College for Women (Autonomous), Sivakasi, Tamil Nadu, India – 626123.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
In 2019 severe acute respiratory syndrome (SARS) - associated with coronavirus is a new highly pathogenic human coronaviruses that emerged in china and has quickly spread all over the world. The mortality rate is about 26% globally. This has resulted in an urgent need to identify antiviral drugs that are active against SARS-Covid -19. Several compounds extracted from natural product and herbs exhibit antiviral activity. In the present study, eight compounds from natural products and five antiviral drugs have selected and docked against SARS-CoV-2. Curcuminoid are chief constituent of turmeric, has been used as a food additive and herbal increment due to its potential medicinal behavior. Curcumin has shown better antiviral effect against dengue, hepatitis C, zika and chikungunya viruses earlier. The molecular docking for exploring the binding abilities between naturally obtained known compounds comparable with Oseltamivir, Remdesivir, hydroxychloroquine, Zanamivir and Ribavirin against SARS-CoV-2, whose results may be used to design potential drug to meet out the need of the hour. The results showed that bismethoxycurcumin, demethoxycurcumin and gedunin have comparable high binding pose energies against SARS-CoV-2. We anticipate that these molecules may lead to the design or discovery of new effective actions for SARS-CoV-2.


Cite this article:
A. Anto Arockia Raj, J. Vinnarasi. Natural Potential Inhibitors for Covid 19 – An Insilico Approach. Research Journal of Pharmacy and Technology. 2021; 14(9):4913-9. doi: 10.52711/0974-360X.2021.00854

Cite(Electronic):
A. Anto Arockia Raj, J. Vinnarasi. Natural Potential Inhibitors for Covid 19 – An Insilico Approach. Research Journal of Pharmacy and Technology. 2021; 14(9):4913-9. doi: 10.52711/0974-360X.2021.00854   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-68


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