Author(s): Veena Kadasala, Niladry Sekhar Ghosh, Santhosh Kumar Chinnaiyan, Arunabha Mallik, Manjunath S.Y., Chiranjib Bhattacharjee

Email(s): chiranjibcology@gmail.com

DOI: 10.52711/0974-360X.2021.00848   

Address: Veena Kadasala1, Niladry Sekhar Ghosh2, Santhosh Kumar Chinnaiyan1, Arunabha Mallik3, Manjunath S.Y.1, Chiranjib Bhattacharjee1*
1Srikrupa Institute of Pharmaceutical Sciences, Vill: Velkatta, Mdl: Kondapak, Dist: Siddipet. Telangana – 502277, India.
2AVIPS, Shobhit University Gangoh Sahranpur - 247341, Uttar Pradesh India.
3Marri Laxman Reddy Institute of Pharmacy Dundigal, Hyderabad, Telangana.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Annona reticulate (AR) is indigenous to the tropical areas of India and worldwide. The use of plant as remedy for diarrhea and ulcer is well documented in Ayurvedic system of medicine. However, pharmacological evidence does not exist to substantiate its therapeutic efficacy for the same. The aim was to investigate the antiulcer and anti-diarrheal activity of methanolic (ME) and aqueous extracts (AE) of A. reticulate in animal model. The antiulcer activity of extracts was investigated using ethanol and pylorus ligation-induced ulcer. The anti-diarrheal activity of MEAR and AEAR extracts was evaluated by castor oil induced diarrhea and gastro intestinal motility using parameters such as onset of diarrhea, number of wet stools, total number of stool and weight of total number of stools. The antiulcer activity of the extracts was confirmed by a reduction in ulcer index along with the decrease in gastric volume, total acidity, and an increase in pH of gastric content in both the models. A. reticulate extracts were more efficacious in reducing number of total stools in both the models of diarrhea and showed a dose-dependent antidiarrheal effect. The obtained results have established a pharmacological evidence for the folkloric use of the A. reticulate as antiulcer and antidiarrhoeal agent.


Cite this article:
Veena Kadasala, Niladry Sekhar Ghosh, Santhosh Kumar Chinnaiyan, Arunabha Mallik, Manjunath S.Y., Chiranjib Bhattacharjee. Phytochemical and Pharmacological Evaluation of Annona reticulate. Research Journal of Pharmacy and Technology. 2021; 14(9):4881-6. doi: 10.52711/0974-360X.2021.00848

Cite(Electronic):
Veena Kadasala, Niladry Sekhar Ghosh, Santhosh Kumar Chinnaiyan, Arunabha Mallik, Manjunath S.Y., Chiranjib Bhattacharjee. Phytochemical and Pharmacological Evaluation of Annona reticulate. Research Journal of Pharmacy and Technology. 2021; 14(9):4881-6. doi: 10.52711/0974-360X.2021.00848   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-62


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