Prabhat Kumar Upadhyay, Prakhar Dixit, Debapriya Garabadu
Prabhat Kumar Upadhyay, Prakhar Dixit, Debapriya Garabadu
Institute of Pharmaceutical Research, GLA University, Mathura - 281406, Uttar Pradesh, India.
Volume - 14,
Issue - 9,
Year - 2021
Cymbopogon citratus (Lemon grass) is well known medicinal herb and distributed in various regions of tropical countries South East Asia. The various parts such as leaves and whole plant of lemongrass are used in the herbal therapies. The essential oil consists of mostly terpenes, aldehyde, ketones, alcohol and esters. Cymbopogon citratus possesses wide range of pharmacological activities including antibacterial, antifungal, antidiarrheal, antifilarial, anti-amoebic and anti-inflammatory. In addition to them, antimalarial, antimycobacterial, hypoglycemic antioxidant, antimutagenicity, and CNS activities were reported. The secondary metabolites like saponins, tannins, anthraquinones, flavonoids, alkaloid phenols and also active constituents from essential oil (such as citral, limonene and terpineol) obtained from the plant are responsible for pharmacological activities. The antioxidant properties of lemongrass help in lowering the risk of cancer through scavenging of free radicals. In this paper, the study emphasizes on systematic study on the potential benefits of plant in the management of various diseases. Therefore, the phytoconstituents and major active constituents from essential oil, determines medicinally properties of lemon grass. The possible mechanisms of action has also been explored in case of some diseases.
Cite this article:
Prabhat Kumar Upadhyay, Prakhar Dixit, Debapriya Garabadu. Pharmacological Activities of Phytoconstituents and Essential oil obtained from Cymbopogon citratus Linn. Research Journal of Pharmacy and Technology. 2021; 14(9):4555-0. doi: 10.52711/0974-360X.2021.00792
Prabhat Kumar Upadhyay, Prakhar Dixit, Debapriya Garabadu. Pharmacological Activities of Phytoconstituents and Essential oil obtained from Cymbopogon citratus Linn. Research Journal of Pharmacy and Technology. 2021; 14(9):4555-0. doi: 10.52711/0974-360X.2021.00792 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-6
1. Carlini EA, Contar J de DP, Silva-Filho AR, da Silveira-Filho NG, Frochtengarten ML, Bueno OF. Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals. J Ethnopharmacol. 1986; 17(1): 37–64.
2. Figueirinha A, Paranhos A, Pérez-Alonso JJ, Santos-Buelga C, Batista, MT. Cymbopogon citratus leaves: Characterization of flavonoids by HPLC–PDA–ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols. Food Chemistry. 2008; 110(3): 718-728.
3. Khanuja SP, Shasany AK, Pawar A, Lal RK, Darokar MP, Naqvi AA, Kumar S. Essential oil constituents and RAPD markers to establish species relationship in Cymbopogon Spreng. (Poaceae). Biochemical Systematics and Ecology. 2005; 33(2): 171-186.
4. Padalia RC, Verma RS, Chanotiya CS, Yadav A. Chemical Fingerprinting of the Fragrance Volatiles of Nineteen Indian Cultivars of Cymbopogon Spreng. (Poaceae). Records of Natural Products. 2011; 5(4): 290.
5. Shackleton CM, Timmermans HG, Nongwe N, Hamer N, Palmer NR. Direct-use values of non-timber forest products from two areas on the Transkei Wild Coast. Agrekon. 2007; 46(1): 113-134.
6. Nguefack J, Leth V, Amvam Zollo PH, Mathur SB. Evaluation of five essential oils from aromatic plants of Cameroon for controlling food spoilage and mycotoxin producing fungi. Int J Food Microbiol. 2004; 94(3): 329–334.
7. Anand R, Kumar P, Kumar G, Kumar N, Kumari K, Prasad N, Kumar D. TLC Profiling of Cymbopogon citratus (Lemongrass) by using Soxhlet Apparatus. Paripex-indian journal of research. 2018; 6 (5): 67-68.
8. Idrees M, Naeem M, Khan MN, Aftab T, Khan MM, Moinuddin. Alleviation of salt stress in lemongrass by salicylic acid. Protoplasma. 2012; 249(3): 709–720.
9. Negrelle RRB, Gomes EC. Cymbopogon citratus (DC.) Stapf: chemical composition and biological activities. Rev Bras Pl Med. 2007; 9(1): 80-92.
10. Boukhatem MN, Kameli A, Ferhat MA, Saidi F, Tayebi K. The food preservative potential of essential oils: is lemongrass the answer?. Journal für Verbraucherschutz und Lebensmittelsicherheit, (2014); 9(1): 13-21.
11. Ross IA. Medicinal plants of the world, Part 1: Chemical constituents, Traditional and Modern medicinal uses. New Jersery: Humana Press Inc, 1999; 119-125.
12. Bharti SK, Kumar A, Prakash O, Krishnan S, Gupta AK. Essential oil of cymbopogon citratus against diabetes: Validation by In vivo experiments and computational studies. Journal of Bioanalysis and Biomedicine. 2013; 5(5): 194–203.
13. Shah G, Shri R, Panchal V, Sharma N, Singh B, Mann AS. Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass). J Adv Pharm Technol Res. 2011; 2(1): 3-8.
14. Saleem M, Afza N, Anwar MA, Hai SMA, Ali MS. A comparative study of essential oils of Cymbopogon citratus and some members of the genus Citrus. Natural product research. 2003; 17(5): 369-373.
15. Pereira RP, Fachinetto R, de Souza Prestes A, et al. Antioxidant effects of different extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus. Neurochem Res. 2009; 34(5): 973–983.
16. Stadler RH, Markovic J, Turesky RJ. In vitro anti- and pro-oxidative effects of natural polyphenols. Biol Trace Elem Res. 1995;47(1-3):299–305.
17. Van Houten B, Woshner V, Santos JH. Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amst). 2006; 5(2): 145–152.
18. Azmi AS, Bhat SH, Hanif S, Hadi SM. Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. FEBS Lett. 2006; 580(2): 533-538.
19. Ewansiha JU, Garba SA, Mawak JD, Oyewole OA. Antimicrobial Activity of Cymbopogon citratus (Lemon Grass) and It's Phytochemical Properties. Frontiers in Science. 2012; 2(6): 214-220.
20. Naik MI, Fomda BA, Jaykumar E, Bhat JA. Antibacterial activity of lemongrass (Cymbopogon citratus) oil against some selected pathogenic bacterias. Asian Pacific Journal of Tropical Medicine, 2010; 3(7): 535-538.
21. Al Yousef SA. Antifungal activity of volatiles from lemongrass (Cymbopogon citratus) and peppermint (Mentha piperita) oils against some respiratory pathogenic species of Aspergillus. Int J Curr Microbiol App Sci. 2013; 2(6): 261-272.
22. Vinitketkumnuen U, Puatanachokchai R, Kongtawelert P, Lertprasertsuke N, Matsushima T. Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known mutagens in salmonella mutation assay. Mutat Res. 1994; 341(1): 71–75.
23. Suaeyun R, Kinouchi T, Arimochi H, Vinitketkumnuen U, Ohnishi Y. Inhibitory effects of lemon grass (Cymbopogon citratus Stapf) on formation of azoxymethane-induced DNA adducts and aberrant crypt foci in the rat colon. Carcinogenesis. 1997; 18(5): 949-955.
24. Kada T, Shimoi K. Desmutagens and bio‐antimutagens–their modes of action. Bioessays. 1987; 7(3): 113-116.
25. de Olinda TM, Lemos TL, Machado LL, Rao VS, Santos FA. Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels. Phytomedicine. 2008; 15(5): 327–333.
26. Whiting PJ. GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?. Drug discovery today. 2003; 8(10): 445-450.
27. Zhou J, Xie G, Yan X. Traditional Chinese medicines: molecular structures, natural sources and applications. 2nd Edition. Ashgate Publishing Ltd. 2002.
28. Hayden MR, Tyagi SC. Intimal redox stress: accelerated atherosclerosis in metabolic syndrome and type 2 diabetes mellitus. Atheroscleropathy. Cardiovasc Diabetol. 2002; 1: 3.
29. Francisco V, Costa G, Figueirinha A, et al. Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid. J Ethnopharmacol. 2013;148(1): 126–134.
30. Yen GC, Duh PD, Huang DW, Hsu CL, Fu TY. Protective effect of pine (Pinus morrisonicola Hay.) needle on LDL oxidation and its anti-inflammatory action by modulation of iNOS and COX-2 expression in LPS-stimulated RAW 264.7 macrophages. Food Chem Toxicol. 2008; 46(1): 175–185.
31. Tchoumbougnang F. Larvicidal activity against Anopheles gambiae Giles and chemical composition of essential oils from four plants cultivated in Cameroon. Biotechnologie, Agronomie, Societe et Environnement. 2009; 13(1): 77-84.
32. Kang DG, Moon MK, Sohn EJ, Lee DH, Lee HS. Effects of morin on blood pressure and metabolic changes in fructose-induced hypertensive rats. Biol Pharm Bull. 2004; 27(11): 1779–1783.
33. Viana GS, Vale TG, Pinho RS, Matos FJ. Antinociceptive effect of the essential oil from Cymbopogon citratus in mice. J Ethnopharmacol. 2000; 70(3): 323–327.
34. Tchoumbougnang F, Zollo PH, Dagne E, Mekonnen Y. In vivo antimalarial activity of essential oils from Cymbopogon citratus and Ocimum gratissimum on mice infected with Plasmodium berghei. Planta Med. 2005; 71(1): 20–23.
35. Sadraei H, Asghari G, Naddafi A. Relaxant effect of essential oil and hydro-alcoholic extract of Pycnocycla spinosa Decne. exBoiss. on ileum contractions. Phytother Res. 2003; 17(6): 645–649.
36. Mayne PD. Clinical Chemistry in Diagnosis and Treatment. Edward Arnold (A division of Hodder Headline Plc), London, 1996. pp.224–241.
37. Silva MR, Ximenes RM, da Costa JG, Leal LK, de Lopes AA, Viana GS. Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice. Naunyn Schmiedebergs Arch Pharmacol. 2010; 381(5): 415–426.
38. Bhalla Y, Gupta VK, Jaitak V. Anticancer activity of essential oils: a review. J Sci Food Agric. 2013; 93(15): 3643–3653.
39. Verma M, Singh SK, Bhushan S, et al. In vitro cytotoxic potential of Polyalthia longifolia on human cancer cell lines and induction of apoptosis through mitochondrial-dependent pathway in HL-60 cells. Chem Biol Interact. 2008; 171(1): 45–56.
40. Thangam R, Sathuvan M, Poongodi A, et al. Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions. Carbohydr Polym. 2014; 107: 138–150.
41. Akhila A. Essential oil bearing plants: The genus Cymbopogon. Edited by: Anand Akhila. Broca Raton, FL: CRC Press Taylor & Francis Group. 2010.