Author(s): Hayder Sabah Hasan, Imad Hashim, Zaid Al-Attar

Email(s): zaidattar@kmc.uobaghdad.edu.iq

DOI: 10.52711/0974-360X.2021.00839   

Address: Hayder Sabah Hasan1, Imad Hashim2, Zaid Al-Attar3
1Lecturer of Physiology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
2Ass. Prof. of Dept. of Pharmacology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
3Lecturer- Pharmacology Dept., Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Objective: To assess the antihypertensive efficacy of the medicinal plants used Hibiscus subdariffa, Plantago major, Teucrium polium. Moreover, we aim to Investigate the mechanisms of actions of tested agents. Design: Induced hypertension in experimental animals is tested against several drugs and medicinal plants extracts. Animals and materials: Hypertension was induced in experimental rabbits with phenylephrine 0.2mg/kg i.v. with increasing the dose (until Blood pressure>130/90mmHg). Rabbits were divided to 7 groups: Control, atenolol, furosemide, candesartan, Hibiscus subdariffa, Plantago major, Teucrium polium. ANOVA with Dunnett's test was implemented for statistical calculations with p<0.05 as significance level. Results: Candesartan was the most effective in lowering both systolic and diastolic blood pressure. Concerning the blood flow, candesartan was found to be the most significantly effective drug in increasing blood flow followed by furosemide and Hibiscus subdariffa respectively. Concerning the urine output furosemide was found to be the most significantly effective drug in increasing urine output followed by Hibiscus subdariffa. The aqueous extracts of Plantago major and Teucrium polium showed no significant effect. Conclusions: Hibiscus subdariffa is effective as diuretic agent at the concentration mentioned. Its action involves diuretic and vasodilator effect. While aqueous extracts of Plantago major and Teucrium polium are not effective.


Cite this article:
Hayder Sabah Hasan, Imad Hashim, Zaid Al-Attar. The Impact of several Antihypertensive drugs and Medicinal herbs on Induced hypertension in rabbits. Research Journal of Pharmacy and Technology. 2021; 14(9):4832-6. doi: 10.52711/0974-360X.2021.00839

Cite(Electronic):
Hayder Sabah Hasan, Imad Hashim, Zaid Al-Attar. The Impact of several Antihypertensive drugs and Medicinal herbs on Induced hypertension in rabbits. Research Journal of Pharmacy and Technology. 2021; 14(9):4832-6. doi: 10.52711/0974-360X.2021.00839   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-53


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