Author(s): Sitti Fatimah, Anny Setijo Rahaju, Alphania Rahniayu

Email(s): anny_sr@fk.unair.ac.id

DOI: 10.52711/0974-360X.2021.00834   

Address: Sitti Fatimah1,2,3, Anny Setijo Rahaju1,2,3*, Alphania Rahniayu1,2,3
1Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Universitas Airlangga Hospital, Universitas Airlangga, Surabaya, Indonesia.
3Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Colorectal adenocarcinoma is positioned as the third of most common cancer which the cases rise in Indonesia lately. More than 90% of colorectal carcinoma are adenocarcinoma type. One of prognostic factor of colorectal adenocarcinoma is invasion state of the tumor (T). Uncontrollable proliferation of tumor cell causes transformation of paracellular permeability that increase claudin-4 expression (a protein located on main integral membrane). Claudin-4 activation influence the expression and activity of MMP-2 directly or by altering transduction signal. Expression of claudin-4 and MMP-2 play a role in tumor invasion. Analyzing correlation of claudin-4 and MMP-2 toward invasion state of the tumor (T stadium) on colorectal adenocarcinoma. Analytical observation was conducted on 47 samples of colorectal adenocarcinoma with different invasion state collected by Laboratory of Pathological Anatomy, Dr. Soetomo General Academic Hospital during 2015-2018. Immunohistochemistry was conducted using both claudin-4 and MMP-2 antibodies. Expression of claudin-4 and MMP-2 were semiquantitatively measured then statistically analyzed. Significant result could be obtained in comparison between claudin-4 and tumor invasion state (p=0.773). The significant result could be obtained in comparison between MMP-2 and tumor invasion state (p=0.920). It also could be observed in comparison between claudin-4 and MMP-2 (p=0.638). In summary, claudin-4 and MMP-2 play a role on tumor invasion colorectal adenocarcinoma. It was showed by significant result between claudin-4 and MMP-2 expressions compared to invasion state of colorectal adenocarcinoma.


Cite this article:
Sitti Fatimah, Anny Setijo Rahaju, Alphania Rahniayu. Role of Claudin-4 and Matrix Metalloproteinase-2 in Tumor Invasion of Colorectal Adenocarcinoma. Research Journal of Pharmacy and Technology. 2021; 14(9):4795-0. doi: 10.52711/0974-360X.2021.00834

Cite(Electronic):
Sitti Fatimah, Anny Setijo Rahaju, Alphania Rahniayu. Role of Claudin-4 and Matrix Metalloproteinase-2 in Tumor Invasion of Colorectal Adenocarcinoma. Research Journal of Pharmacy and Technology. 2021; 14(9):4795-0. doi: 10.52711/0974-360X.2021.00834   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-48


REFERENCES:
1.    Kuipers EJ, Grady WM, Lieberman D, et al. Colorectal cancer. Nat Rev Dis Primers. 2015; 1: 15065.
2.    Brenner H, Kloor M, Pox CP. Colorectal cancer. Lancet. 2014; 383 (9927): 1490-1502.
3.    Setyowibowo H, Purba FD, Hunfeld JAM, et al. Quality of life and health status of Indonesian women with breast cancer symptoms before the definitive diagnosis: A comparison with Indonesian women in general. PLoS One. 2018; 13(7): e0200966.
4.    Tong GJ, Zhang GY, Liu J, et al. Comparison of the eighth version of the American Joint Committee on Cancer manual to the seventh version for colorectal cancer: A retrospective review of our data. World J Clin Oncol. 2018; 9(7): 148-161.
5.    Takehara M, Nishimura T, Mima S, et al. Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. Biol Pharm Bull. 2009; 32(5): 825-831.
6.    Murray GI, Duncan ME, Arbuckle E, et al. Matrix metalloproteinases and their inhibitors in gastric cancer. Gut. 1998; 43(6): 791-797.
7.    Fadholly A, Ansori ANM, Proboningrat A, et al. Apoptosis of hela cells via caspase-3 expression induced by chitosan-based nanoparticles of Annona squamosa leaf extract: In vitro study. Indian Journal of Pharmaceutical Education and Research. 2020; 54(2), pp. 416-421
8.    Fadholly A, Ansori ANM, Jayanti S, et al. Cytotoxic effect of Allium cepa L. Extract on human colon cancer (widr) cells: In vitro study. Res J Pharm Tech. 2019; 12(7): 3483-3486.
9.    Ansori ANM, Fadholly A, Kharisma VD, et al. Therapeutic potential of avian paramyxovirus serotype 1 for cancer therapy. Biochem Cell Arch. 2020; 20: 2827-2832.
10.    Redston M, Drima D. Epithelial neoplasms of the large intestine. In: Odze, RD and Goldblum, JR., Eds. Odze and Goldblum. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. Elsevier Inc. 737-770; 2015.
11.    Kang MK, Kang DK. Esophageal neuroendocrine carcinoma with focal squamous cell carcinoma component. J Investig Med High Impact Case Rep. 2020; 8: 2324709620918245.
12.    American Cancer Society. What is Colorectal Cancer. American Cancer Society; 2018.
13.    Zayed KS. Detection of mutation in codon 12 of KRAS gene in Iraqi patients with colorectal adenocarcinoma. Research J Pharm Tech. 2018; 11(3): 1041-1047.
14.    Kwon MJ. Emerging roles of claudins in human cancer. Int J Mol Sci. 2013; 14(9): 18148-18180.
15.    Süren D, Yıldırım M, Kaya V, et al. Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal carcinoma. Med Sci Monit. 2014; 20: 1255-1262.
16.    Said AH, Raufman JP, Xie G. The role of matrix metalloproteinases in colorectal cancer. Cancers. 2014; 6(1): 366-375.
17.    Ahmad AM. Colorectal cancer. Medscape. 2018; 241-254.
18.    Hua H, Li M, Luo T, et al. Matrix metalloproteinases in tumorigenesis: an evolving paradigm. Cell Mol Life Sci. 2011; 68(23): 3853-3868.
19.    Agarwal R, D'Souza T, Morin PJ. Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res. 2005; 65(16): 7378-7385.
20.    Cabibi D, Calascibetta A, Aragona F, et al. Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma. Anticancer Res. 2009; 29(11): 4417-4422.
21.    Ding L, Lu Z, Lu Q, Chen YH. The claudin family of proteins in human malignancy: a clinical perspective. Cancer Manag Res. 2013; 5: 367-375.
22.    Fedchenko N, Reifenrath J. Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review. Diagn Pathol. 2014; 9: 221.
23.    Salvador E, Burek M, Förster CY. Tight junctions and the tumor microenvironment. Curr Pathobiol Rep. 2016; 4: 135-145.
24.    Hwang TL, Lee LY, Wang CC, et al. Claudin-4 expression is associated with tumor invasion, MMP-2 and MMP-9 expression in gastric cancer. Exp Ther Med. 2010; 1(5): 789-797.
25.    Wu YL, Zhang S, Wang GR, et al. Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion. World J Gastroenterol. 2008; 14(31): 4943-4948.
26.    Kinugasa T, Huo Q, Higashi D, et al. Selective up-regulation of claudin-1 and claudin-2 in colorectal cancer. Anticancer Res. 2007; 27(6A): 3729-3734.
27.    Oshima T, Kunisaki C, Yoshihara K, et al. Reduced expression of the claudin-7 gene correlates with venous invasion and liver metastasis in colorectal cancer. Oncol Rep. 2008; 19(4): 953-959.
28.    Usami Y, Chiba H, Nakayama F, et al. Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus. Hum Pathol. 2006; 37(5): 569-577.
29.    Abd-Elazeem MA, Abd-Elazeem MA. Claudin 4 expression in triple-negative breast cancer: correlation with androgen receptors and Ki-67 expression. Ann Diagn Pathol. 2015; 19(1): 37-42.
30.    Westermarck J, Kähäri VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999; 13(8): 781-792.

Recomonded Articles:

Author(s): Karpagam T, Jannathul Firdous, Revathy, Shanmuga Priya, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad

DOI: 10.5958/0974-360X.2019.00360.3         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Harsha Vardhani Kondepati, Girish Pai Kulyadi, Vamshi Krishna Tippavajhala

DOI: 10.5958/0974-360X.2018.00069.0         Access: Open Access Read More

Author(s): Shukla Maitri Jayeshkumar, Patel Yashvi, Bhavin Bhimani, Ghanshyam Patel, Jaimin Patel, Upendra Patel

DOI: 10.5958/0974-360X.2019.00157.4         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): S. Gupta, A. M. Shaikh, B. Mohanty, P. Chaudhari, P. B. Parab, K. G. Apte

DOI: 10.5958/0974-360X.2020.00325.X         Access: Open Access Read More

Author(s): D Saha, D Mridha, S Mondal, M Jana, S Kayal

DOI: Not Available         Access: Open Access Read More

Author(s): Muddukrishna B.S. Krishnamurthy Bhat, Gautham G. Shenoy

DOI: Not Available         Access: Open Access Read More

Author(s): Amurdhavani. B.S

DOI: Not Available         Access: Open Access Read More

Author(s): Nirisha Sriram, Gheena. S, Samrithi Yuvaraj

DOI: 10.5958/0974-360X.2015.00180.8         Access: Open Access Read More

Author(s): S. A. Moniish Kumaar, R. Prasanth Babu, P. Vivek, D. Saravanan

DOI: 10.5958/0974-360X.2020.00440.0         Access: Open Access Read More

Author(s): Ajay Kumar K., Lokeshwari D.M., Pavithra G., Vasanth Kumar G.

DOI: Not Available         Access: Open Access Read More

Author(s): Nugraeni Yuli, Riawan Wibi, Permatasari Nur, Widjajanto Edy, Dradjat Respati S

DOI: 10.5958/0974-360X.2019.00758.3         Access: Open Access Read More

Author(s): P. Bangaraiah, P. Ashok Kumar

DOI: 10.5958/0974-360X.2017.00079.8         Access: Open Access Read More

Author(s): Sumithra. M, Mohamed Majeed. A, Chitra. V

DOI: 10.5958/0974-360X.2020.00290.5         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags