Author(s): Anshul Kumar, Rajnish Kumar, Avijit Mazumdar

Email(s): anshulumar447@gmail.com

DOI: 10.52711/0974-360X.2021.00831   

Address: Anshul Kumar*, Rajnish Kumar, Avijit Mazumdar
Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-II, Institutional Area, Greater Noida, UP- 201306, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Terazosin hydrochloride is an anti-hypertensive drug which is used to treat the diseases of hypertension. The literature survey shows the proposed synthesis of Terazosin hydrochloride derived from the starting material of 2-chloro-6, 7-dimethoxy–quinazoline-4-amine in the presence of 2-methoxy ethanol with n- benzyl piperazine to form the product. The Terazosin derivatives were prepared with the help of literature survey were 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1, 4-bis-(tertrahydrofuran-2-yl) carbonyl piperazine, and 1-(4-amino-6, 7-dimethoxy- quinazoline-2-yl)- 4-formyl- piperazine were prepared by maintaining environmental condition. The characterization done for prepared derivative was done through 1H-NMR, MASS and IR Spectroscopy. The antibacterial activity of prepared derivatives was performed on the various bacteria like E. coli, Pseudomonas aeruginosa, Shigella sonneii, Klebsiella pneumonia, Staphylococcus aureus, Shigella flexneri, Vibrio cholera, Bacillus subtilis, Pseudomonas fluorescens, Pseudomonas aeruginosa, Staphylococcus aureus. The desired derivatives shown maximum zone of inhibition using concentration prepared 100µg and 200µg using standard drug. The derivatives that shows maximum inhibition 6, 7-dimethoxy-2-piperazine-1-yl-quinazoline -4-amine and minimum was shown by 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1,4-bis-(tertrahydrofuran- 2-yl) carbonyl piperazine. The result should that prepared Terazosin derivatives shows potent actively when compared with standard ciprofloxacin.


Cite this article:
Anshul Kumar, Rajnish Kumar, Avijit Mazumdar. Synthesis Characterization and Antibacterial Activity of Terazosin Hydrochloride Drug and Market Formulation. Research Journal of Pharmacy and Technology. 2021; 14(9):4777-2. doi: 10.52711/0974-360X.2021.00831

Cite(Electronic):
Anshul Kumar, Rajnish Kumar, Avijit Mazumdar. Synthesis Characterization and Antibacterial Activity of Terazosin Hydrochloride Drug and Market Formulation. Research Journal of Pharmacy and Technology. 2021; 14(9):4777-2. doi: 10.52711/0974-360X.2021.00831   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-45


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