Anshul Kumar, Rajnish Kumar, Avijit Mazumdar
Anshul Kumar*, Rajnish Kumar, Avijit Mazumdar
Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-II, Institutional Area, Greater Noida, UP- 201306, India.
Volume - 14,
Issue - 9,
Year - 2021
Terazosin hydrochloride is an anti-hypertensive drug which is used to treat the diseases of hypertension. The literature survey shows the proposed synthesis of Terazosin hydrochloride derived from the starting material of 2-chloro-6, 7-dimethoxy–quinazoline-4-amine in the presence of 2-methoxy ethanol with n- benzyl piperazine to form the product. The Terazosin derivatives were prepared with the help of literature survey were 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1, 4-bis-(tertrahydrofuran-2-yl) carbonyl piperazine, and 1-(4-amino-6, 7-dimethoxy- quinazoline-2-yl)- 4-formyl- piperazine were prepared by maintaining environmental condition. The characterization done for prepared derivative was done through 1H-NMR, MASS and IR Spectroscopy. The antibacterial activity of prepared derivatives was performed on the various bacteria like E. coli, Pseudomonas aeruginosa, Shigella sonneii, Klebsiella pneumonia, Staphylococcus aureus, Shigella flexneri, Vibrio cholera, Bacillus subtilis, Pseudomonas fluorescens, Pseudomonas aeruginosa, Staphylococcus aureus. The desired derivatives shown maximum zone of inhibition using concentration prepared 100µg and 200µg using standard drug. The derivatives that shows maximum inhibition 6, 7-dimethoxy-2-piperazine-1-yl-quinazoline -4-amine and minimum was shown by 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1,4-bis-(tertrahydrofuran- 2-yl) carbonyl piperazine. The result should that prepared Terazosin derivatives shows potent actively when compared with standard ciprofloxacin.
Cite this article:
Anshul Kumar, Rajnish Kumar, Avijit Mazumdar. Synthesis Characterization and Antibacterial Activity of Terazosin Hydrochloride Drug and Market Formulation. Research Journal of Pharmacy and Technology. 2021; 14(9):4777-2. doi: 10.52711/0974-360X.2021.00831
Anshul Kumar, Rajnish Kumar, Avijit Mazumdar. Synthesis Characterization and Antibacterial Activity of Terazosin Hydrochloride Drug and Market Formulation. Research Journal of Pharmacy and Technology. 2021; 14(9):4777-2. doi: 10.52711/0974-360X.2021.00831 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-45
1. Deger G., Effect of Terazosin on serum lipids. Am. J. Med.; 1986: pp.80: 82-85.
2. Fischer J., Ganellin C.R., Analogue based drug discovery. John Willey and Sons; 2006: pp.455.
3. Abraham PA, Halstenson CE, Matzke GR, Napier JL, Keane WF. “Antihypertensive therapy with once-daily administration of terazosin, a new alpha-1 adrenergic-receptor blocker”. Pharm; 1985: 285-289.
4. Jackson EK, Garrison JK. Renin and angiotensin. “In Goodman and Gilman’s The pharmacological basis of therapeutics”. 9th Ed. JG Hardman, A Goodman Gilman, Lee E Limbird. McGraw Hill New York;1995: pp.733-758.
5. Mostafa, A.A., Al-Askar, A.A., Almaary, K.S., Dawoud, T.M., Sholkamy, E.N. and Bakri, M.M., 2017. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi Journal of Biological Sciences, Vol 1, pp 365.
6. Haviv, F. and DeNet, R.W. Antiinflammatory 1-(quinolinyl)- 2-pyrazoline derivatives. U.S. Patent 4; 1983; pp. 407, 803.
7. Rai, J., Randhawa, G.K. and Kaur , M., 2013. Recent advances in antibacterial drugs. International Journal of Applied and Basic Medical Research, 3(1).
8. Ullah H., Ali S., Classification of antibacterial agents and their functions ;2017: doi. 10.5772/intechopen.68695.
9. Munita J.M., Arias C.A., Mechanisms of Antibiotic resistance virulence mechanisms of bacterial pathogens, Fifth edition; 481-511.
10. Harbarth, S. and Samore, M.H., 2005. Antimicrobial resistance determinants and future control. Emerging Infectious Diseases; 2005; 11(6): 794.
11. Baquero, F., Beltrén, J.M. and Loza, E. A review of antibiotic resistance patterns of Streptococcus pneumoniae in Europe. Journal of Antimicrobial Chemotherapy.1991; 28: 31-38.
12. Asamenew G., Bisrat D., Mazumder A. and Asres K. In-vitro antimicrtobial and antioxidant activities of Anthrone and Chromone from the latex of Aloeharlana Reynolds. Phytotherapy Research; 2011; 25(12): 1756-1760.