Author(s): Krishna Kishore Adireddy, Srinivasa Rao Baratam, Nagarjuna Hari Pratap S

Email(s): adireddi.kk@gmail.com

DOI: 10.52711/0974-360X.2021.00829   

Address: Krishna Kishore Adireddy*, Srinivasa Rao Baratam, Nagarjuna Hari Pratap S
Department of Pharmaceutical Analysis, St. Ann's College of Pharmacy, Vizianagaram, Andhra Pradesh-535003, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
A simple, rapid, accurate and precise RP-HPLC method was developed and validated for the determination of Istradefylline in table dosage form. Chromatographic analysis of the drug was achieved on Shimadzu HPLC comprising of LC- 20 AD binary gradient pump, a variable wavelength programmable SPD-20A detector and SCL system controller. C18G column (250 mm x 4.6 mm, 5 µ) as stationary phase with mobile phase consisting of 0.1 % orthophosphoric acid and acetonitrile in the ratio of 30: 70 v/v. The method showed a good linear response in the concentration range of 10-90 µg/ml with correlation coefficient of 0.9993. The flow rate was maintained at 1.0 ml/min and detection was carried out at 246 nm. The retention time was 3.125 min. The method was statistically validated for accuracy, precision, linearity, ruggedness, robustness, solution stability, selectivity and sensitivity. The results obtained in the study were within the limits of ICH guidelines and hence this method can be used for the determination of istradefylline in tablet formulation.


Cite this article:
Krishna Kishore Adireddy, Srinivasa Rao Baratam, Nagarjuna Hari Pratap S. Method Development and Validation for Estimation of Istradefylline in Tablet Dosage form by RP-HPLC. Research Journal of Pharmacy and Technology. 2021; 14(9):4767-2. doi: 10.52711/0974-360X.2021.00829

Cite(Electronic):
Krishna Kishore Adireddy, Srinivasa Rao Baratam, Nagarjuna Hari Pratap S. Method Development and Validation for Estimation of Istradefylline in Tablet Dosage form by RP-HPLC. Research Journal of Pharmacy and Technology. 2021; 14(9):4767-2. doi: 10.52711/0974-360X.2021.00829   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-43


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DOI: 10.5958/0974-360X 

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