Author(s): Porkodi Karthikeyan, M.V. Dass Prakash, Pavithra Devi Sendurapandi, Kalaiselvi Periandavan

Email(s): pkalaiselvi2011@gmail.com

DOI: 10.52711/0974-360X.2021.00827   

Address: Porkodi Karthikeyan1, M.V. Dass Prakash2, Pavithra Devi Sendurapandi3, Kalaiselvi Periandavan4
1Research Scholar, Department of Medical Biochemistry, Dr. ALMPGIBMS, University of Madras, Taramani Campus, Chennai.
2Assistant Professor, Sri Sankara Arts and Science College (Autonomous), Kanchipuram, Tamil Nadu, India.
3Research Scholar, Department of Biochemistry, Sri Sankara Arts and Science College (Autonomous), Kanchipuram, Tamil Nadu, India.
4Associate Professor, Department of Medical Biochemistry, Dr. ALMPGIBMS, University of Madras, Taramani Campus, Chennai
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Diabetes Mellitus is a metabolic disorder characterized by elevated blood glucose level caused due to deficiency of insulin secretion or insulin action. The management of the blood glucose level is an important approach in the control of diabetes mellitus complications. There are many divergent therapeutic strategies in the management of Type II diabetes. The inhibition of carbohydrate hydrolyzing enzymes such as a-amylase and a-glucosidase can be used to lower postprandial blood glucose levels. The objective of the present study is to evaluate the inhibitory potential of Gymnemic acid in various concentrations on a-amylase and a-glucosidase activities. Gymnemic acid and voglibose show the IC50 value of 68.12 and 46.23 on alpha amylase and IC50 value of 65.77 and 36.67 on alpha glucosidase activity respectively. Insilico docking study between a-amylase and a-glucosidase with gymnemic acid and voglibose depict the similar amino acid binding sites that substantiate that gymnemic acid might be used as a natural and cost-effective alternative to the synthetic drug. This study throws light on the anti-diabetic action of phytomedicine, Gymnemic acid, a component of Gymnema sylvestre.


Cite this article:
Porkodi Karthikeyan, M.V. Dass Prakash, Pavithra Devi Sendurapandi, Kalaiselvi Periandavan. Assessment of the antidiabetic potential of Gymnemic acid as α-amylase and α-Glucosidase inhibitor using invitro and insilico tools. Research Journal of Pharmacy and Technology. 2021; 14(9):4755-9. doi: 10.52711/0974-360X.2021.00827

Cite(Electronic):
Porkodi Karthikeyan, M.V. Dass Prakash, Pavithra Devi Sendurapandi, Kalaiselvi Periandavan. Assessment of the antidiabetic potential of Gymnemic acid as α-amylase and α-Glucosidase inhibitor using invitro and insilico tools. Research Journal of Pharmacy and Technology. 2021; 14(9):4755-9. doi: 10.52711/0974-360X.2021.00827   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-41


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