Author(s): Harini Venkata Subbiah, Usha Subbiah, Athira Ajith

Email(s): ushat75@yahoo.com

DOI: 10.52711/0974-360X.2021.00823   

Address: Harini Venkata Subbiah, Usha Subbiah*, Athira Ajith
Human Genetics Research Centre, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Dental caries is a multifactorial disease that affects a large proportion of the population with both genetic and environmental factors contributing to the disease. Even in healthy oral environmental conditions, some individuals are susceptible to dental caries due to potential genetic contribution. Antimicrobial peptides are expressed in oral cavity and play an important role against microbial colonization and form an important first line defense against cariogenic bacteria. In the present study, we attempt to identify genetic variants that would cause significant functional impact towards susceptibility to dental caries. We investigated single nucleotide polymorphisms (SNPs) of beta-defensin 1 (DEFB1) as predictors of dental caries in tamil ethnic population. A total of 120 subjects were recruited for this study, which included 60 dental caries patients (DMFT>5) and 60 healthy controls (DMFT=0). Three SNPs of 5’UTR regulatory elements of DEFB1 were genotyped by PCR followed by Sanger sequencing. The genotypes associated with susceptibility to caries were found to be significant between rs11362 (p=.025, odds ratio = 3.72, 95% confidence interval (CI) = 1.289-10.742), rs1799946 (p=.023, odds ratio=4.32, 95% CI = 1.33-14.028) gene polymorphisms and risk of dental caries (DMFT>5) in tamil ethnicity. The variant genotype GG of rs1800972 polymorphism was found to be high in cases than controls but was not significant (p=0.136). Our data suggested that ß-defensin 1 polymorphisms play a role in the susceptibility to dental caries.


Cite this article:
Harini Venkata Subbiah, Usha Subbiah, Athira Ajith. Association of β-defensin 1 gene Polymorphism and dental caries susceptibility in Tamil Ethnicity. Research Journal of Pharmacy and Technology. 2021; 14(9):4731-5. doi: 10.52711/0974-360X.2021.00823

Cite(Electronic):
Harini Venkata Subbiah, Usha Subbiah, Athira Ajith. Association of β-defensin 1 gene Polymorphism and dental caries susceptibility in Tamil Ethnicity. Research Journal of Pharmacy and Technology. 2021; 14(9):4731-5. doi: 10.52711/0974-360X.2021.00823   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-37


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