Author(s): Nilesh K. Patel, Bhumika H. Rana, Dhruti M. Patel, Amitkumar J. Vyas, Ashok B. Patel, Ajay I. Patel

Email(s): ranabhumika777@gmail.com

DOI: 10.52711/0974-360X.2021.00789   

Address: Dr. Nilesh K. Patel1, Bhumika H. Rana1*, Dhruti M. Patel1, Dr. Amitkumar J. Vyas1, Dr. Ashok B. Patel1, Dr. Ajay I. Patel1
B.K. Mody Government Pharmacy College, Rajkot, Gujrat, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
RP- UPLC method was developed and validated for the simultaneous determination of Rabeprazole sodium and Mosapride citrate in tablet dosage form. The separation was achieved on a BEH C18 (50mm × 2.1mm× 1.7µm) column using mobile phase of Ammonium acetate buffer: Acetonitrile (60:40% v/v). The flow rate was 0.4 ml/min and detection was carried out at 270nm and column oven 35ºC. Rabeprazole sodium and Mosapride citrate was subjected to stress condition including Acidic, Alkaline, Oxidation, Photolysis and Thermal degradation. This method was validated as per ICH (Q2R1) guideline.


Cite this article:
Nilesh K. Patel, Bhumika H. Rana, Dhruti M. Patel, Amitkumar J. Vyas, Ashok B. Patel, Ajay I. Patel. Stability Indicating RP-UPLC Method for Simultaneous Estimation of Rabeprazole Sodium and Mosapride Citrate in Tablet Dosage form. Research Journal of Pharmacy and Technology. 2021; 14(9):4535-9. doi: 10.52711/0974-360X.2021.00789

Cite(Electronic):
Nilesh K. Patel, Bhumika H. Rana, Dhruti M. Patel, Amitkumar J. Vyas, Ashok B. Patel, Ajay I. Patel. Stability Indicating RP-UPLC Method for Simultaneous Estimation of Rabeprazole Sodium and Mosapride Citrate in Tablet Dosage form. Research Journal of Pharmacy and Technology. 2021; 14(9):4535-9. doi: 10.52711/0974-360X.2021.00789   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-3


REFERENCES:
1.    Desai CA, Samant BD.A Review of Rabeprazole. Journal of Postgraduate Medicine. 2002; 48-50.
2.    Drug Profile and Information of Mosapride citrate, September 2019,https://pubchem.ncbi.nlm.nih.gov/compound/Mosapride-citrate
3.    Drug Combination, “Rabeprazole sodium and Mosapride citrate”, September 2019, https://www.1mg.com/drugs/rabeflux-20mg-15mg-tablet-305046
4.    Blessy M, Patel RD, Prajapati PN and Agrawal YK. Development of forced degradation and stability indicating studies of drugs – A review. Journal of Pharmaceutical Analysis. 2013; 4:159- 165.
5.    ICH – Harmonized Tripartite Guideline, “Stability testing of New drug substance and products Q1A (R2)”, International Conference on Harmonization, IFPMA, Geneva, Switzerland, 2003.
6.    Choudary SP and Chandrudu J. Simultaneous estimation of Rabeprazole and Mosapride by RP-HPLC method in tablet dosage form. International Journal of Pharmacy and Analytical Research. 2018; 7: 116-128.
7.    Chawla G and Chanda R. Principle, instrumentation, and applications of UPLC: a novel technique of liquid chromatography. Open Chemistry Journal.2006; 3: 1-16.
8.    Patel BH, Suhagia BN, Patel MM and Patel JR. High-Performance Liquid Chromatography and Thin-Layer Chromatography for the Simultaneous Quantitation of Rabeprazole and Mosapride in Pharmaceutical Products. Journal of Chromatographic Science. 2008; 46: 10-14.
9.    Kumar SA, Debnath M and Padala V. An Isocratic Method Development and Validation for simultaneous estimation of Rabeprazole and Mosapride in Tablet Dosage Forms by using RP-HPLC. Pharma Tutor. 2016; 4: 41-51
10.    Mohammed AB, Gunasekar M, Alhazmi HA, Hafiz AM and Daghriri O. Development and validation of RP-HPLC method for the estimation of Rabeprazole and Mosapride in raw and capsule formulation. Der Pharm Chemica. 2016; 8: 140-146.
11.    Saravanan G, Padmaja M, Geethanjali J and Visagaperumal D. Stability Indicating RP-HPLC Method for Estimation of Rabeprazole Sodium and Mosapride Citrate in Bulk and Formulation. International Journal of pharmacy and Pharmaceutical Science. 2014; 6: 265-269.
12.    ICH – Harmonized Tripartite Guideline, “Validation of analytical procedures: text and methodology Q2 (R1)”, International Conference on Harmonization, IFPMA, Geneva, Switzerland, 2005

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