Author(s): Michael Josef Kridanto Kamadjaja, Sherman Salim, Birgitta Dwitya Swastyayana Subiakto

Email(s): michael-j-k-k@fkg.unair.ac.id

DOI: 10.52711/0974-360X.2021.00807   

Address: Michael Josef Kridanto Kamadjaja1, Sherman Salim1, Birgitta Dwitya Swastyayana Subiakto2
1Departement of Prosthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - Indonesia.
2Resident of Prosthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Objective: This study was to determine OPG and RANKL expression after hydroxyapatite (HA) scaffold from crab shells (Portunus pelagicus) application in tooth socket of Cavia cobaya. Methods: This study was a post-test only control group design. Twenty four Cavia cobaya was divided into 4 groups. The lower left incisor was extracted and given a combination of HA and gelatin scaffold. Experimental animals were sacrificed on the 7th and 14th day. The amount of OPG and RANKL expression was calculated under a light microscope at 1000x magnification. The statistical analysis was done by One Way ANOVA Test and Tukey HSD. Results: Compared to other groups, the lowest and the highest level of OPG and RANKL were in P14 group. Conclusion: HA scaffold from crab shells (Portunus pelagicus) can increase OPG expression and decrease RANKL expression in the process of regenerating alveolar bone after tooth extraction.


Cite this article:
Michael Josef Kridanto Kamadjaja, Sherman Salim, Birgitta Dwitya Swastyayana Subiakto. Application of Hydroxyapatite scaffold from Portunus pelagicus on OPG and RANKL expression after tooth extraction of Cavia cobaya. Research Journal of Pharmacy and Technology. 2021; 14(9):4647-1. doi: 10.52711/0974-360X.2021.00807

Cite(Electronic):
Michael Josef Kridanto Kamadjaja, Sherman Salim, Birgitta Dwitya Swastyayana Subiakto. Application of Hydroxyapatite scaffold from Portunus pelagicus on OPG and RANKL expression after tooth extraction of Cavia cobaya. Research Journal of Pharmacy and Technology. 2021; 14(9):4647-1. doi: 10.52711/0974-360X.2021.00807   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-21


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