Om M. Bagade, Ashwini R. Mali, Saroja S. Survase, Ankita K. Chaudhari, Priyanka E. Doke
Om M. Bagade1*, Ashwini R. Mali1, Saroja S. Survase1, Ankita K. Chaudhari1, Priyanka E. Doke2
1Department of Pharmaceutics, PES Modern College of Pharmacy (For Ladies), Moshi, Pune - 412105, Maharashtra, India.
2Department of Pharmaceutics, D. Y. Patil International University, School of Pharmacy, Akurdi, Pune - 411044.
Volume - 14,
Issue - 8,
Year - 2021
Among the various routes of drug delivery, the oral route is an attractive site for the delivery of drugs. The main advantages of these formulations are: drug targeting, sustained release, increased permanence time in the buccal mucosa, increased bioavailability, and decreased potential adverse effects and maintains constant blood levels for extended period of time. The buccal cavity was found to be the most suitable and easily accessible site for the delivery of therapeutic agents for both local and systemic delivery. Buccal mucosa has a tremendous availability, which leads to direct access to systemic circulation through the internal jugular vein bypasses the drug from hepatic first pass metabolism. The main disadvantage of this route is Limited absorption area- the total surface area of the membranes of the oral cavity available for drug absorption is 170 cm2 of which ~50 cm2 represents non-keratinized tissues, including buccal membrane, the barrier function of the skin changes from one site to the other and from one person to other person with age and large dose of drug are difficult to be administered. Melt granulation is emerging technique and this technique used to increase the dissolution rate of poorly water-soluble drugs. Tablet molding technique: Tablets produced by the molding technique are easier to scale up for industrial manufacture than lyophilisation technique. Hot melt extrusion of film method: Hot melt extrusion has been used for the manufacture of controlled release matrix tablets, pellets and granules, as well as oral disintegrating films.
Cite this article:
Om M. Bagade, Ashwini R. Mali, Saroja S. Survase, Ankita K. Chaudhari, Priyanka E. Doke. An Updated Overview on Mucoadhesive Buccal Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(8):4495-0. doi: 10.52711/0974-360X.2021.00781
Om M. Bagade, Ashwini R. Mali, Saroja S. Survase, Ankita K. Chaudhari, Priyanka E. Doke. An Updated Overview on Mucoadhesive Buccal Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(8):4495-0. doi: 10.52711/0974-360X.2021.00781 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-87
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