Popat Kumbhar, Tejaswini Shinde, Tejaswini Jadhav, Tejas Gavade, Rushikesh Sorate, Uma Mali, John Disouza, Arehalli Manjappa
Popat Kumbhar*, Tejaswini Shinde, Tejaswini Jadhav, Tejas Gavade, Rushikesh Sorate, Uma Mali, John Disouza, Arehalli Manjappa
Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra, India, 416113.
Volume - 14,
Issue - 8,
Year - 2021
Vesicular drug delivery systems including niososmes, liposomes, pharmacosomes, transferosomes, electrosomes, ethosomes, etc have been widely accepted for controlled delivery of the drug. Amongst, all these drug delivery systems pharmacosomes are gaining more attention of the researchers due to several benefits such as high entrapment efficiency, improved biopharmaceutical properties, and pharmacokinetic performance, no leakage or loss of drug, stability, etc. Pharmacosomes are amphiphilic phospholipid complexes of drugs having active hydrogen that bind to phospholipids and self-assembled into vesicles in an aqueous medium. Both hydrophilic and lipophilic drugs have been formulated into pharmacosomes that caused improved solubility and permeability of drugs. Pharmacosomes are prepared by using various techniques such as hand shaking method, ether injection, solvent evaporation method, supercritical fluid approach, etc and are characterized for prodrug confirmation, surface morphology, crystal state measurement, in vitro drug release, and stability, etc. Despite wide research and highly encouraging results in the preclinical studies, translation of these nanomedicines from laboratory to market has been very limited. The main aim of this review is to describe comprehensively the potential of pharmacosomes as a vesicular drug delivery system focusing mainly on their conventional and advanced methods of preparation, different characterization techniques, and their applications in the delivery of different types of drugs with improved biopharmaceutical properties and pharmacokinetic performance.
Cite this article:
Popat Kumbhar, Tejaswini Shinde, Tejaswini Jadhav, Tejas Gavade, Rushikesh Sorate, Uma Mali, John Disouza, Arehalli Manjappa. Pharmacosomes: An approach to improve biopharmaceutical properties of drugs basic considerations in development. Research Journal of Pharmacy and Technology. 2021; 14(8):4485-0. doi: 10.52711/0974-360X.2021.00779
Popat Kumbhar, Tejaswini Shinde, Tejaswini Jadhav, Tejas Gavade, Rushikesh Sorate, Uma Mali, John Disouza, Arehalli Manjappa. Pharmacosomes: An approach to improve biopharmaceutical properties of drugs basic considerations in development. Research Journal of Pharmacy and Technology. 2021; 14(8):4485-0. doi: 10.52711/0974-360X.2021.00779 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-85
1. Mukherjee PK, Maiti K, Kumar V. Value added drug delivery systems with botanicals: Approach for dosage development from natural resources. Pharm Rev 2007; 6: 57-60.
2. Samuni A, Chong P, Barenholz LGY, Thompson TE. Physical and chemical modifications of adriamycirdron complex by phospholipid bilayers. Cancer Res 1986; 46: 594-9.
3. Tanhuanpaa K, Cheng KH, Anttonen K. Characteristics of pyrene phospholipid/g-cyclodextrin complex. Biophys J 2001; 81(9): 1501-10.
4. Roohi K, Dilip KP, Anupam S, Vikas K, Bhaskar M. Ethosomes: A novel approach for transdermal and topical drug delivery. Research J. Topical and Cosmetic Sci. 2015; 6(1): 15-20.
5. Kshitij BM, Suraj RW. Niosome: A novel drug delivery system. Asian J. Pharm. Res. 2013; 3(1): 15-19.
6. Nilesh VK, Vijay RM. Ethosomes: A novel drug carrier. Res. J. Topical and Cosmetic Sci. 2013; 4(1): 84-91.
7. Gondkar SB, Nikita SM, Saudagar RB. An overview on trends and development of niosomes as drug delivery. Research J. Topical and Cosmetic Sci. 2016; 7(2): 79-85.
8. Semalty A, Semalty M, Rawat BS, Singh D, Rawat MS. Pharmacosomes: the lipid-based new drug delivery system. Expert Opin. Drug Delivery 2009; 6:599-612.
9. Pathak K, Keshri L, Shah M. Lipid nanocarriers: influence of lipids on product development and pharmacokinetics. Crit. Rev. Ther. Drug Carrier Syst. 2011; 28: 357-93.
10. Selvaraju K, Vengadesh PK, Karthick K, Padma Preetha J, Arul Kumaran K.S.G. Pharmacosomes: An Immense Potential Vesicular Constructs. Research J. Pharma. Dosage Forms and Tech. 2011; 3(3): 84-86.
11. Nilesh V.K, Vijay RM. Ethosomes: A novel drug carrier. Res. J. Topical and Cosmetic Sci. 2013; 4(1): 84-91.
12. Shivhare SC, Malviya KG, Vijay J, Guatam Ni. A review on liposomes as a novel drug delivery system. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 193-198.
13. Suraj RW, Abhishek DD, Mohan AU, Rahul MB, Dhaval PG, Rinkesh RM, Syed MF. Liposome as a drug delivery system: A review. Research J. Pharma. Dosage Forms and Tech. 2012; 4(2): 104-112.
14. Yogita R, Shital S, Aishwarya P, Manojkumar N, Shrinivas M. Phytosomes: A novel approach in herbal drug delivery system. Asian J. Res. Pharm. Sci. 2018; 8(3): 151-154.
15. Little A, Levy R, Chuaqui-kidd P, Hand D. Double-blind, placebo-controlled trial of high-dose lecithin in Alzheimer’s disease. J Neurol Neurosurg Psychiatary 1985; 48: 736-42.
16. Shepherd RW, Bunting PS, Khan M, Hill JG, Soldin SJ, Gall DG. A rapid, sensitive method for accurate analysis of individual bile acids in biological fluids by high performance thin layer chromatography and densitometry. Clin. Biochem. 1978; 11: 106-11.
17. Cholkar K, Trinh HM, Vadlapudi AD, Mitra AK. Synthesis and characterization of ganciclovir Long chain lipid prodrugs. Adv. Ophthalmol. Vis. Syst. 2014;1.
18. Ruan J, Liu J, Zhu D, Gong T, Yang F, Hao X, Zhang Z. Preparation and evaluation of self nanoemulsified drug delivery systems (SNEDDS) of matrine based on drug–phospholipid complex technique. Int. J. Pharm. 2010; 386: 282-90.
19. Song Y, Zhuang J, Guo J, Xiao Y, Ping Q. Preparation and properties of a silybinphospholipid complex. Die Pharmazie- An Int. J. Pharm. Sci. 2008; 63: 35-42.
20. Qin X, Yang Y, Fan TT, Gong T, Zhang XN, Huang Y. Preparation, characterization and in vivo evaluation of bergenin-phospholipid complex. Acta Pharmacol. Sin. 2010; 31: 127-36.
21. Xia HJ, Zhang ZH, Jin X, Hu Q, Chen XY, Jia XB. A novel drug–phospholipid complex enriched with micelles: Preparation and evaluation in vitro and in vivo. Int. J. Nanomed. 2013; 545-54.
22. Supraja B, Mulangi S. An updated review on pharmacosomes, a vesicular drug delivery system. J Drug Delivery Ther 2019; 9: 393-402.
23. Semalty A, Semalty M, Rawat B S, Singh D, Rawat MSM. Development and evaluation of pharmacosomes of aceclofenac. IJPS 2010; 72: 576-81.
24. Semalty A, Semalty M, Rawat BS, Singh D, Rawat MSM. Development and characterization of aspirin- phospholipid complex for improved drug delivery. IJPS 2010; 2(2): 940-947.
25. Semalty A, Semalty M, Rawat BS, Singh D, Rawat MSM. Development and physicochemical evaluation of pharmacosomes of diclofenac. IJPS 2010; 59: 335-344
26. Letha S, Shammika P, Viswanand V. Formulation and evaluation of etodolac pharmacosomes: A novel approach towards rheumatoid arthritis. IJPT 2017; 9(2): 29665-29680.
27. Raikhman L M, Ivanov V E, Moshkovskii Y S. Development of Ibuprofen pharmacosomes for enhancing the bioavailability. Drug Dev Indian Pharm. 2002; 28(5): 473-482.
28. Kamalesh M, Baviskar D, Wagh K, Baviskar K. Formulation and evaluation of pharmacosomes of Ketoprofen. Indo Am J Pharm Res. 2014; 4(3): 1363-1368.
29. Kolar kusuma, D. Priyanka, J. Sundaraseelan. Formulation and evaluation of pharmacosomal gel loaded with NSAID. WJPMR 2018; 4(7): 81-88.
30. Yep PF, Zheng Q, Bin W, Yang M, Wang MS, Zhang HY. Process optimization by response surface design and characterization study on Geniposide pharmacosomes. Pharm Dev Technol. 2012; 17(1): 94-102.
31. Yi-Guang J, Ping A I, Miao L I and Xin-Pu H. Preparation and properties of Acyclovir pharmacosomes. Chinese J Pharma. 2005; 36(10): 617-620.
32. Ping A, Jin Y, Da-Wei C. Preparation and in-vivo behavior of didanosine pharmacosomes in rats. CJP 2005; 3: 227– 235.
33. Kiruthika, S. Design and development of pharmacosomes for oral delivery of Losartan. 2018.
34. Sultana S, Sindhuri T, Parveen P, Mahathi K. An updated overview on pharmacosomes. IJUPBS 2014; 3(3): 710-731.
35. Patil SD, Chatap VK, Patil PL. In-vitro, ex-vivo characterization of Furosemide bounded pharmacosomes for improvement of solubility and permeability. Adv Pharmacol Pharm. 2014; 2(5): 67-76.
36. Puroshotham M, Viswanath V, Narasimharoa B, Sujitha B, Sireesha S. Formulation and evaluation of pharmacosomes containing Ornidazole. WJPR 2015; 4(9): 926-941.
37. Kumar PT, Mishra J, Podder A. Design, fabrication and evaluation of Rosuvastatin pharmacosomes: A novel sustained drug delivery system, EJPMR. 2016; 3: 4: 332-350.