Author(s): Lim Chiew Vien, Sasikala Chinnappan, Mogana R


DOI: 10.52711/0974-360X.2021.00776   

Address: Lim Chiew Vien, Sasikala Chinnappan*, Mogana R
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021

Garcinia mangostana L or Mangosteen is being used traditionally as a medicine. Mangosteen is a tropical fruit harvested from trees, geographically distributed in Malaysia, India and Sri Lanka with a long history of traditional medicinal usage for the treatment of chronic diarrhoea, dysentery, infected wounds, skin infections and antioxidant activities. Alpha mangostin, a chemical entity from mangosteen and it has been reported to have a wide spectrum of biological activities such as anti-inflammatory, cardioprotective, anti-tumour, antidiabetic activity, antibacterial, antifungal, antioxidant, antiparasitic and anti-obesity. This review aims to highlight the antioxidant activity of Garcinia mangostana L and alpha mangostin.

Cite this article:
Lim Chiew Vien, Sasikala Chinnappan, Mogana R. Antioxidant activity of Garcinia mangostana L and alpha mangostin: A Review. Research Journal of Pharmacy and Technology. 2021; 14(8):4466-0. doi: 10.52711/0974-360X.2021.00776

Lim Chiew Vien, Sasikala Chinnappan, Mogana R. Antioxidant activity of Garcinia mangostana L and alpha mangostin: A Review. Research Journal of Pharmacy and Technology. 2021; 14(8):4466-0. doi: 10.52711/0974-360X.2021.00776   Available on:

1.    Yaacob O, Tindall HD. Mangosteen Cultivation. FAO Plant Production and Protection Paper Food and Agriculture Organization of the United Nations, Belgium 129 (1st ed). 1995.
2.    Hyun-Ah Jung BNS, William J Keller, Rajendra G, Mehta A, Douglas Kinghorn.  Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen). J. Agric. Food Chem. 2006; 54: 2077−2082.
3.    3.Pedraza-Chaverrí J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Perez Rojas JM. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol.2008; 46: 3227–3239.
4.    Michelle Ooi Yi Ching, Sasikala Chinnappan, & Mogana Sundari Rajagopal. In vitro anti-motility and antispasmodic effects of Garcinia mangostana extracts in isolated chicken ileum preparation. International Journal of Research in Pharmaceutical Sciences. 2019. 10(2); 1444-1447.
5.    Watanabe M, Gangitano E, Francomano D. Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study. Nutrients. 2018; 10(5): 586.
6.    El-Seedi HR, El-Ghorab DM, El-Barbary MA, Zayed MF, Goransson U, Larsson S, Verpoorte R. Naturally occurring xanthones; latest investigations: isolation, structure elucidation and chemosystematic significance. Curr Med Chem. 2009; 16(20): 2581–2626.
7.    Chen S, Han K, Li H, Cen J, Yang Y, Wu H, Wei Q. Isogarcinol extracted from Garcinia mangostana L. ameliorates imiquimod-induced psoriasis-like skin lesions in mice. J Agric Food Chem, 2017; 65: 846–57.
8.    Jung HA, Su BN, Keller WJ, Mehta RG, Kinghorn AD. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem.2006; 54: 2077– 2082.
9.    Harrison NLJ. Xanthones from the heartwood of Garcinia mangostana. Phytochemistry.2002; 60: 541–548.
10.    Nattaya, Chairungsrilered KAT, Asushi Y, Ohzumi, Shigeo Nozoe, Tomihisa.  Mangostanol, A Prenyl Xanthone From Garcinia Mangostana. Pytochemistry. 1996; 43(5), 1099-1102.
11.    Zadernowski R, Czaplicki S, Naczk M. Phenolic acid profiles of mangosteen fruits (Garcinia mangostana). Food Chem. 2009; 112: 685–689.
12.    Shanzao Chen, Kesheng Han, Hu Li, Juren Cen, Yanfang Yang, Hezhen Wu, and Qun Wei, Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in Mice. Journal of Agricultural and Food Chemistry. 2017; 65 (4): 846-857.
13.    Wittenauer J, Falk S, Schweiggert-Weisz U, Carle R. Characterisation and quantification of xanthones from the aril and pericarp of mangosteens (Garcinia mangostana L.) and a mangosteen containing functional beverage by HPLC–DAD–MSn. Food Chemistry. 2012; 134(1): 445-452.
14.    Mohamed GA, Al-Abd AM, El-halawanye AM, Abdallaha HM, Ibrahim SRM. New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines. J Ethnopharmacol. 2017; 198: 302–12.
15.    Chairungsrilerd NK, Furukawa T, Ohta S, Nozoe Y, Ohizumi. Pharmacological properties of α-mangostin, a novel histamine H<sub>1</sub> receptor antagonist. European Journal of Pharmacology. 1996; 314: 351-356.
16.    Shankaranarayan DC, Gopalakrishnan L, Kameswaran. Pharmacological profile of mangostin and its derivatives Arch Internat Pharmaco Therapie. 1979; 239: 257-269.
17.    Tewtrakul SC, Wattanapiromsakul W, Mahabusarakam. Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264. 7 macrophage cells, Journal of Ethnopharmacology. 2009; 121: 379-382.
18.    Akao YY, Nakagawa Y, Nozawa. Anti-cancer effects of xanthones from pericarps of mangosteen, International Journal of Molecular Sciences. 2008; 9: 355-370.
19.    Chitchumroonchokchai CJM. Thomashner J, Li KM, Riedl J. Nontakham S, Suksumrarn SK, Clinton AD, Kinghorn ML, Failla. Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Molecular Nutrition & Food Research. 2013; 57: 203-211.Devi Sampath PK. Vijayaraghavan. Cardioprotective effect of α-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats. Journal of Biochemical and Molecular Toxicology. 2007; 21: 336-339.
20.    Pradeep kumar SV, Puranik SB, Nandini BN. Evaluation of Alpha-Mangostin, Isolated and Purified from the Crude Extract of Garcinia mangostana for the Anti-Diabetic, Anti-Inflammatory and Antioxidant Activity. International journal of pharmacy and pharmaceutical research.2017;8(2): 75-95.
21.    Negi P, Jayaprakasha G, Jena B. Antibacterial activity of the extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata against food borne pathogens and spoilage bacteria. LWT-Food Science and Technology. 2008; 41, 1857–1861.
22.    Sundaram B, Gopalakrishnan C, Subramanian S, Shankaranarayanan D, Kameswaran L. Antimicrobial activities of Garcinia mangostana. Plant Medicine.1983; 48: 59–60.
23.    Kaomongkolgit R, Jamdee K, Chaisomboon N. Antifungal activity of alpha-mangostin against Candida albicans. Journal of Oral Science.2009; 51, 401–406.
24.    Marquez-Valadez B, Maldonado PD, Galván-Arzate S. Alpha-mangostin induces changes in glutathione levels associated with glutathione peroxidase activity in rat brain synaptosomes. Nutr Neurosci. 2012; 15(5): 13-19.
25.    Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother. Res. 2009; 23: 1047–1065
26.    Quan X, Wang Y, Ma X, Liang Y, Tian W, Ma Q, Jiang H, Zhao Y. alpha mangostin induces apoptosis and suppresses differentiation of 3T3-L1 Cells via inhibiting fatty acid synthase. PLoS One. 2012; 7(3): e33376.
27.    Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. 2016; 3164734.
28.    Haida Z, and Hakiman M. A comprehensive review on the determination of enzymatic assay and nonenzymatic antioxidant activities. Food Science & Nutrition. 2019; 7(5): 1555-1563.
29.    Pisoschi A, Pop A. The role of antioxidants in the chemistry of oxidative stress: A review. European Journal of Medicinal Chemistry. 2015; 97: 55–74.
30.    Vinita Sindhi , Vartika Gupta, Kameshwar Sharma,Sonal Bhatnagar, Reeta Kumari, Neeti Dhaka. Potential applications of antioxidants- A review. Journal of Pharmacy Research. 2013; 7(9): 828-835.
31.    Nuttavut Kosema, Youn-Hee Hanb and Primchanien Moongkarndia. Antioxidant and Cytoprotective Activities of Methanolic Extract from Garcinia mangostana Hulls. Science Asia. 2007; 33: 283-292.
32.    Arasali Sulaiman Zarena, Kadimi Udaya Sankar. A Study of Antioxidant Properties from Garcinia Mangostana L. Pericarp Extract. Acta Sci. Pol. Technol. Aliment. 2009; 8(1): 23-34.
33.    Ani Kurniawati, Roedhy Poerwanto, Sobir, Darda Effendi, and Herry Cahyana. Evaluation of Fruit Characters, Xanthones Content, and Antioxidant Properties of Various Qualities of Mangosteens (Garcinia mangostana L.) J. Agron. Indonesia. 2010; 38 (3): 232 – 237.
34.    Susy Tjahjania, Wahyu Widowatia, Khie Khionga, Adrian Suhendraa, Rita Tjokropranotoa. Antioxidant Properties of Garcinia mangostana L (Mangosteen) Rind. Procedia Chemistry. 2014; 13:198 – 203.
35.    Wichit Suthammarak, Pornpayom Numpraphrut, Ratiya Charoensakdi, Neelobol Neungton, Vachara Tunrungruangtavee, Nattapon Jaisupa, Suwit Charoensak, PrimchanienMoongkarndi, and Weerasak Muangpaisan. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans, Oxidative Medicine and Cellular Longevity. 2016; 1-10.
36.    Purwantiningsih Sugita, Salsabila Arya, Auliya Ilmiawati and Budi Arifin. Characterization, antibacterial and antioxidant activity of mangosteen (Garcinia mangostana l.) pericarp nanosized extract. Rasayan, J.Chem. 2017;10 (3): 707 – 715.
37.    Yik-Ling Chew, Yau-Yan Lim. Evaluation and Comparison of Antioxidant Activity of Leaves, Pericarps and Pulps of Three Garcinia Species in Malaysia. Free Radicals and Antioxidants. 2018; 8(2): 130-134.
38.    Andri Kusmayadi1, Lovita Adriani, Abun Abun, Muchtaridi Muchtaridi, Ujang Hidayat Tanuwiria.  Antioxidant activity of mangosteen peel (Garcinia mangostana L.) extracted using different solvents at the different times. Drug Invention Today. 2019; 11(1): 44-48.
39.    Marquez-Valadez B, Lugo-Huitro R, Valdivia-Cerda V, Miranda- Ramırez LR, Perez-De La Cruz V, Gonzalez-Cuahutencos O, Rivero-Cruz I, Mata R, Santamarıa A, Pedraza- Chaverrı J. The natural xanthone a mangostin reduces oxidative damage in rat brain tissue. Nutritional Neuroscience. 2009; 12: 35–42.
40.    Marquez-Valadez B, Maldonado PD, Galvan-Arzate S. Alpha-mangostin induces changes in glutathione levels associated with glutathione peroxidase activity in rat brain synaptosomes. Nutr Neurosci. 2012; 15(5): 13-19.
41.    Jazmin M. Perez-Rojas, Cristino Cruzb , Patricia Garcia-Lopezc , Dolores J Sanchez-Gonzalezd , Claudia M Martínez-Martinezd , Gisela Ceballose , Jorge Meléndez-Zajglae and José Pedraza-Chaverri. Renoprotection by α-mangostin is related to the attenuation in renal oxidative/nitrosative stress and inflammation induced by cisplatin nephrotoxicity. Free Radical Research. 2009; 1-36.
42.     Pradeep kumar SV, Puranik SB, Nandini BN.  Evaluation of Alpha-Mangostin, Isolated and Purified from the Crude Extract of Garcinia mangostana for the Anti Diabetic, Anti-Inflammatory and Antioxidant Activity. Ijppr.Human. 2017; 8(2): 75−95.
43.    Alpha-mangostin attenuates oxidative stress and inflammation in adjuvant-induced arthritic rats Yiwen Xu, Huimin Zhou and Lin Cai. Tropical Journal of Pharmaceutical Research. 2017; 16 (11): 2611-2616.
44.    Lestari N, Pratama S, Gotama KT, Soetikno V, Louisa M.  Antioxidative activity of alpha-mangostin in acetaldehyde-induced hepatic stellate cells: An in vitro study. International Journal of Applied Pharmaceutics. 2019; 11: 164-167.

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