Author(s): Agrima Srivastava, Himani Awasthi, Dipti Srivastava, Zeeshan Fatima, Vivek Srivastava

Email(s): himani1july@gmail.com

DOI: 10.52711/0974-360X.2021.00702   

Address: Agrima Srivastava, Himani Awasthi*, Dipti Srivastava, Zeeshan Fatima, Vivek Srivastava
Amity Institute of Pharmacy, Amity University, Uttar Pradesh, Lucknow, Campus.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
Bioactive flavonoid Naringenin has very high nutritional value. Several investigations suggested that supplementation of this bioactive flavonoid is beneficial for health. Naringenin have been found in variety of herbs and fruits which are used for daily consumption like citrus species, tomatoes and figs. This study aimed to explore the effect of flavonoid naringenin on oxidative damage, memory impairment and cholinergic dysfunction induced by Cadmium chloride (5mg/kg p.o) in mice. In this experiment naringenin (20 and 40 mg/kg, p.o.) was given orally for the duration of 28 days in Swiss mice. Memory function was assessed by using elevated plus maze test and morris water maze. Cholinergic function and oxidative stress were estimated in brain homogenate after behavioral study. It was found that naringenin improved memory impairment in cadmium chloride treated mice. Naringenin increases the level of reduced glutathione (GSH) and decreases the level of malondialdehyde (MDA) in brain, helps in memory improvement and decrease oxidative stress.


Cite this article:
Agrima Srivastava, Himani Awasthi, Dipti Srivastava, Zeeshan Fatima, Vivek Srivastava. Exploring the effect of Naringenin against Cadmium Induced Neurotoxicity in mice model. Research Journal of Pharmacy and Technology. 2021; 14(8):4053-9. doi: 10.52711/0974-360X.2021.00702

Cite(Electronic):
Agrima Srivastava, Himani Awasthi, Dipti Srivastava, Zeeshan Fatima, Vivek Srivastava. Exploring the effect of Naringenin against Cadmium Induced Neurotoxicity in mice model. Research Journal of Pharmacy and Technology. 2021; 14(8):4053-9. doi: 10.52711/0974-360X.2021.00702   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-8


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