Author(s): Adryan Fristiohady, Muhammad Hajrul Malaka, Andi Rizqa Wahyuni Safitri, Dewo Diha, Saripuddin, La Ode Muhammad Julian Purnama, Sudarman Rahman, Agung Wibawa Mahatva Yodha, Dian Munasari, Baru Sadarun, Idin Sahidin

Email(s): adryanfristiohady@uho.ac.id

DOI: 10.52711/0974-360X.2021.00770   

Address: Adryan Fristiohady1*, Muhammad Hajrul Malaka1, Andi Rizqa Wahyuni Safitri1, Dewo Diha1, Saripuddin1, La Ode Muhammad Julian Purnama1, Sudarman Rahman1, Agung Wibawa Mahatva Yodha1, Dian Munasari1, Baru Sadarun2, Idin Sahidin1
1Faculty of Pharmacy, Halu Oleo University, Kendari, Southeast Sulawesi, Indonesia.
2Faculty of Fisheries and Marine Science, Halu Oleo University, Kendari, Southeast Sulawesi, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
Inflammation is the host's protective response to any stimulus that harms the body. Excessive inflammatory process causes tissue damage. Therefore, an anti-inflammatory agent is needed. The use of natural ingredients, especially sea sponges, is an option to reduce the side effects of anti-inflammatory agents. This utilization is related to the discovery of new agents. So, we tested the effect of the ethanol extract of Petrosia sp. as an anti-inflammatory agent. Animal induced with 1% carrageenan and left for 1 hour. After that the animals were divided into 6 groups (n = 4) and given oral treatment, namely: Group I (normal group); Group II (negative group); Group III (ethanol extract of Petrosia sp. Concentration of 0.05mg/ml); Group IV (ethanol extract of Petrosia sp. Concentration 0.1mg/ml); Group V (ethanol extract of Petrosia sp. Concentration 0.2mg/ml); and Group VI (positive group, Diclofenac Sodium). After 1 hour, the animals were measured for edema volume and plasma TNF-a levels. Based on the research conducted, the ethanol extract of Petrosia sp. decreased edema volume and plasma TNF-a levels in inflammatory mice. The concentration of 0.2mg/mL had a significant effect on the negative control used (p <0.05). On the other hand, Petrosia sp. indicates the presence of alkaloids, flavonoids, and steroids. They may play an important role in the anti-inflammatory process. Thus, it can be concluded that the ethanol extract of Petrosia sp. has anti-inflammatory activity.


Cite this article:
Adryan Fristiohady, Muhammad Hajrul Malaka, Andi Rizqa Wahyuni Safitri, Dewo Diha, Saripuddin, La Ode Muhammad Julian Purnama, Sudarman Rahman, Agung Wibawa Mahatva Yodha, Dian Munasari, Baru Sadarun, Idin Sahidin. Anti-Inflammatory Activity of Ethanol Extract of Marine Sponge Petrosia Sp. by Supression the Level of Tumor Necrosis Factor-alpha. Research Journal of Pharmacy and Technology. 2021; 14(8):4435-9. doi: 10.52711/0974-360X.2021.00770

Cite(Electronic):
Adryan Fristiohady, Muhammad Hajrul Malaka, Andi Rizqa Wahyuni Safitri, Dewo Diha, Saripuddin, La Ode Muhammad Julian Purnama, Sudarman Rahman, Agung Wibawa Mahatva Yodha, Dian Munasari, Baru Sadarun, Idin Sahidin. Anti-Inflammatory Activity of Ethanol Extract of Marine Sponge Petrosia Sp. by Supression the Level of Tumor Necrosis Factor-alpha. Research Journal of Pharmacy and Technology. 2021; 14(8):4435-9. doi: 10.52711/0974-360X.2021.00770   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-76


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