Author(s): C.C. Patil, J. Vekatesh, Karajgi S. R, Vijapure Vitthal, Ashwini G., Jorapur P. N., Chetan M.

Email(s): Email ID Not Available

DOI: 10.52711/0974-360X.2021.00769   

Address: C.C. Patil*, J. Vekatesh, Karajgi S. R, Vijapure Vitthal, Ashwini G., Jorapur P. N., Chetan M.
B.L.D.E.A’s SSM College of Pharmacy and Research Centre, BLDE University Campus, Vijaypur - 586103, Karnataka, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
The aim of this project was to develop sustained release matrix tablets of Repaglinide. Sustained release matrix tablets of Repaglinide were prepared by the wet granulation method using polymers like Hydroxy propyl methyl cellulose, Microcrystalline cellulose, Eudragit RS-100 in different ratios. The matrix tablets of Repaglinide were evaluated for hardness, weight variation, friability, drug content uniformity, and in-vitro drug release. In order to determine the drug release mechanisms and kinetics, the data was subjected to zero order, first order, and higuchi and peppas diffusion model. Twelve batches of sustained release matrix tablets of Repaglinide were developed. Among these formulations F4, F8 and F12 formulation showed satisfactory physicochemical properties and drug content uniformity and sustained release of drug for 12 hours with maximum release of 86.95%, 84.91% and 84.91%. The optimized formulations were characterized for Differential scanning calorimetric analysis; Fourier transforms infrared spectroscopy and scanning electron microscopic studies. IR spectroscopic studies indicated that there were no drug-excipient interactions. The prepared sustained release matrix tablets of Repaglinide were successfully developed and evaluated.


Cite this article:
C.C. Patil, J. Vekatesh, Karajgi S. R, Vijapure Vitthal, Ashwini G., Jorapur P. N., Chetan M. Formulation and in vitro Evaluation of Matrix tablets containing Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(8):4429-4. doi: 10.52711/0974-360X.2021.00769

Cite(Electronic):
C.C. Patil, J. Vekatesh, Karajgi S. R, Vijapure Vitthal, Ashwini G., Jorapur P. N., Chetan M. Formulation and in vitro Evaluation of Matrix tablets containing Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(8):4429-4. doi: 10.52711/0974-360X.2021.00769   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-75


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