Author(s): M. Sharmal Kumar, N. Arunagirinathan, M. Ravikumar

Email(s): ravikumar_micro@rediffmail.com

DOI: 10.52711/0974-360X.2021.00768   

Address: M. Sharmal Kumar1, N. Arunagirinathan2, M. Ravikumar1*
1PG and Research Department of Botany, Government Arts College for Men (Autonomous), Nandanam, Affiliated to University of Madras, Chennai - 600035, India.
2Department of Microbiology and Biotechnology, Presidency College (Autonomous), Affiliated to University of Madras, Chennai 600005, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
The aim of this study was to analyze the extended spectrum ß-lactamases (ESBLs) production and antibiotic susceptibility profile of urinary tract infected bacterial pathogens such as Escherichia coli and Klebsiella spp. A total of 143 Gram-negative bacteria were isolated from people suffering from urinary tract infections (UTIs) were included in this study. Among them, Escherichia coli (75%) were the predominantly isolated bacterial pathogen followed by Klebsiella oxytoca (14.6%) and K. pneumoniae (10.4%). Approximately 65% (n=93) of isolates were positive for ESBL production and E.coli was found to be the highest ESBL producer (67.6%) followed by K. oxytoca (57.1%) and K. pneumoniae (53.3%). E. coli showed high level of 86.1% resistance to cefotaxime and cefuroxime and 100% sensitive to imipenem and meropenem, whereas, K. oxytoca showed high level of 90.5% resistance to cefuroxime and 100% sensitive to amikacin, imipenem and meropenem. Similarly, K. pneumoniae showed high level of 73.3% resistance to nitrofurantoin and 93.3% sensitive to imipenem. This study reveals that majority of UTIs caused bacteria are ESBL producing multidrug-resistant bacteria and showing broad spectrum antibiotic resistance profile.


Cite this article:
M. Sharmal Kumar, N. Arunagirinathan, M. Ravikumar. Antibiotic susceptibility profile of extended spectrum β-lactamase producing Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca from Urinary tract infections. Research Journal of Pharmacy and Technology. 2021; 14(8):4425-8. doi: 10.52711/0974-360X.2021.00768

Cite(Electronic):
M. Sharmal Kumar, N. Arunagirinathan, M. Ravikumar. Antibiotic susceptibility profile of extended spectrum β-lactamase producing Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca from Urinary tract infections. Research Journal of Pharmacy and Technology. 2021; 14(8):4425-8. doi: 10.52711/0974-360X.2021.00768   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-74


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