Author(s):
Dharmastuti Cahya Fatmarahmi, Ratna Asmah Susidarti, Respati Tri Swasono, Abdul Rohman
Email(s):
abdul_kimfar@ugm.ac.id
DOI:
10.52711/0974-360X.2021.00766 
Address:
Dharmastuti Cahya Fatmarahmi1, Ratna Asmah Susidarti2, Respati Tri Swasono3, Abdul Rohman2,4*
1Student of Doctoral Program, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia, 55281.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia, 55281.
3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281.
4Institute of Halal Industry and System (IHIS), Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281.
*Corresponding Author
Published In:
Volume - 14,
Issue - 8,
Year - 2021
ABSTRACT:
The study aims to develop an effective, efficient, and reliable method using Fourier Transform Infrared (FTIR) spectroscopy with Attenuated Total Reflection (ATR) combined with chemometric for identifying the synthetic drug in Indonesian herbal medicine known as Jamu. Jamu powders, Metamizole, and the binary mixture of Jamu and Metamizole were measured using FTIR-ATR at the mid-infrared region (4000-650 cm-1). The obtained spectra profiles were further analyzed by Principal Component Analysis, Partial Least Square Regression, Principal Component Regression, and Discriminant Analysis. Jamu Pegel Linu (JPL), Jamu Encok (JE), Jamu Sakit Pinggang (JSP), Metamizole (M), and adulterated Jamu by Metamizole were discriminated well on PCA score plot. PLSR and PCR showed the accuracy and precision data to quantify JPL, JE, and JSP, and each adulterated by M with R2 value > 0,995 and low value of RMSEC and RMSEP. Discriminant Analysis (DA) was successfully grouping Jamu and Metamizole without any misclassification. A combination of FTIR spectroscopy and chemometrics offered useful tools for detecting Metamizole in traditional herbal medicine.
Cite this article:
Dharmastuti Cahya Fatmarahmi, Ratna Asmah Susidarti, Respati Tri Swasono, Abdul Rohman. Identification and Quantification of Metamizole in Traditional Herbal Medicines using Spectroscopy FTIR-ATR combined with Chemometrics. Research Journal of Pharmacy and Technology. 2021; 14(8):4413-9. doi: 10.52711/0974-360X.2021.00766
Cite(Electronic):
Dharmastuti Cahya Fatmarahmi, Ratna Asmah Susidarti, Respati Tri Swasono, Abdul Rohman. Identification and Quantification of Metamizole in Traditional Herbal Medicines using Spectroscopy FTIR-ATR combined with Chemometrics. Research Journal of Pharmacy and Technology. 2021; 14(8):4413-9. doi: 10.52711/0974-360X.2021.00766 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-72
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