Author(s): Priya Gupta, Vanita Kanase

Email(s): vanita.kanase@gmail.com

DOI: 10.52711/0974-360X.2021.00764   

Address: Ms. Priya Gupta1, Dr. Vanita Kanase2*
1Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra 400705.
2HOD Pharmacology, Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra 400705.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
The purpose of the present work were intended to determine the antihistaminic activity of ethanolic extract of Capparis moonii W. fruits (EECM). Capparis moonii W. had been historically used in the diagnosis of cough and asthma and so we undertook this study to validate scientifically using appropriate animal models. Antihistamine is considered to be helpful for the treatment of allergic, thus, the antihistamine activity of an ethanolic extract of Capparis moonii W. in the current work was evaluated. To determine the doses, acute oral toxicity tests were conducted. Clonidine and haloperidol that induced cataleptic effect in Swiss albino mice were evaluated for antihistaminic activity at the different doses of 50mg/kg, 100mg/kg and 200mg/kg, p.o. and the evaluation is also done on guinea pig ileum tissue. The ethanolic extract of Capparis moonii W. fruits (50, 100, 200mg/kg, p.o.) and chlorpheniramine maleate (i.p.,10mg/kg) significantly inhibited (****P<0.0001) clonidine induced catalepsy but the extract donot inhibit haloperidol-induced catalepsy and histamine-induced contraction in guinea pig ileum tissue preparation shows that ethanolic extract of Capparis moonii W. inhibited the contractile activity of histamine. The result of our work shows that the ethanolic extract possesses antihistaminic activity. It can be reported that flavonoid present in the extract may be important for an antihistaminic effect and therefore may have a role in the asthma treatment.


Cite this article:
Priya Gupta, Vanita Kanase. Antihistaminic activity of Ethanolic extract of Capparis moonii W. fruit. Research Journal of Pharmacy and Technology. 2021; 14(8):4403-7. doi: 10.52711/0974-360X.2021.00764

Cite(Electronic):
Priya Gupta, Vanita Kanase. Antihistaminic activity of Ethanolic extract of Capparis moonii W. fruit. Research Journal of Pharmacy and Technology. 2021; 14(8):4403-7. doi: 10.52711/0974-360X.2021.00764   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-70


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