Author(s): Murad Alam, Kifayat Ullah Shah, Kamran Ahmad Khan, Asif Nawaz, Hadia Bibi, Ghulam Razaque, Zahid Rasul Niazi, Mulham Alfatama

Email(s): mulham@unisza.edu.my

DOI: 10.52711/0974-360X.2021.00762   

Address: Murad Alam1, Kifayat Ullah Shah1, Kamran Ahmad Khan1, Asif Nawaz1, Hadia Bibi2, Ghulam Razaque3, Zahid Rasul Niazi4, Mulham Alfatama5*
1Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Khyber Pakhtukhwa, Pakistan.
2Department of Pharmacy, Women Institute of Learning, Abottabad, Pakistan.
3Department of Pharmaceutics, Faculty of Pharmacy, University of Balochistan, Quetta, Pakistan.
4Department of Basic Medical Sciences, Faculty of Pharmacy, University of Balochistan, Quetta, Pakistan.
5Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Besut Campus, 22200, Malaysia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
The development of floating tablets with required buoyancy, lag time, and controlling release behaviour of drugs at target site is truly interesting and challenging task for researchers. Current study is concerned with the designing of effervescent floating controlled release tablets of clarithromycin and famotidine to treat peptic ulcer due to Helicobacter pylori (H. pylori) infection. Five formulations (F1-F5) were prepared, among which three formulations were of bilayered tablets while the remaining were included as plain tablets. These tablets were prepared by direct compression method using hydroxypropyl methylcellulose (HPMC) K100M, HPMC K4M and sodium bicarbonate as swelling and floating agents respectively. The qualitative tests such as thickness, hardness, weight variation, friability and uniformity of content were performed to ensure the quality of prepared tablets. The floating lag time of all formulations ranged from 14 to 20 seconds. The effervescent floating tablets with HPMC K4M (F1, F3 & F5) attained the total floating time of more than 12 hours, while tablets prepared with HPMC K100M (F2 & F4) achieved the total floating time of less than 7 hours. This difference in floating behaviour could be due to the variation in compaction and flow properties of the two polymers. The formulations with HPMC K100M (F2 & F4) have comparatively more sustained drug release properties when compared to F1, F3 and F4 using HPMC K4M as swelling and floating polymers. This could be attributed to better compaction of HPMC K100M. The prepared tablets follow non-Fickian diffusion kinetics. Overall, these floating controlled release effervescent bilayer and plain tablets may enhance the compliance and therapeutic outcomes of clarithromycin and famotidine in treatment of H. pylori.


Cite this article:
Murad Alam, Kifayat Ullah Shah, Kamran Ahmad Khan, Asif Nawaz, Hadia Bibi, Ghulam Razaque, Zahid Rasul Niazi, Mulham Alfatama. Formulation and in vitro Evaluation of Effervescent Bilayer Floating Controlled Release Tablets of Clarithromycin and Famotidine. Research Journal of Pharmacy and Technology. 2021; 14(8):4391-8. doi: 10.52711/0974-360X.2021.00762

Cite(Electronic):
Murad Alam, Kifayat Ullah Shah, Kamran Ahmad Khan, Asif Nawaz, Hadia Bibi, Ghulam Razaque, Zahid Rasul Niazi, Mulham Alfatama. Formulation and in vitro Evaluation of Effervescent Bilayer Floating Controlled Release Tablets of Clarithromycin and Famotidine. Research Journal of Pharmacy and Technology. 2021; 14(8):4391-8. doi: 10.52711/0974-360X.2021.00762   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-68


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