Author(s): Sharath Kumar C, Navin Patil, Amrita Parida, Kabirdev, Prachi Priyadarshini, Shanti Gurung, Karthik Rao N, Manju V

Email(s): amrita_parida@yahoo.com

DOI: 10.52711/0974-360X.2021.00753   

Address: Sharath Kumar C1, Navin Patil2, Amrita Parida*1, Kabirdev1, Prachi Priyadarshini1, Shanti Gurung2, Karthik Rao N 3, Manju V4
1Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India.
2Department of Pharmacology, UCMS, Bhairahawa, Rupandehi, Nepal.
3Department of Medicine, KS Hegde Medical Academy, Mangaluru.
4Department of Paediatrics, Melaka-Manipal Medical College, Manipal Campus, Manipal Academy of Higher Education, Manipal, Karnataka, India – 576104.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
Aim: To investigate the antiepileptic activity of vortioxetine. Materials and method: Vortioxetine was screened for its antiepileptic activity in Sprague-Dawley rats using maximal electroshock model. 4 groups of rats (each 6 rats) were used. First group was administered distilled water, second group diazepam and the third and fourth groups were given vortioxetine 10mg/kg and 20mg/kg respectively. These drug were given 30 minutes before the animal was subjected to electroshock (150mA, 50Hz for 0.2 seconds). Results: Vortioxetine effectively reduced tonic hind limb extension (THLE) in the rats and the effect was statistically significant compared to the control group. The seizure duration was also significantly lower compared to the control. There was no substantial difference in the duration of seizures and THLE between the diazepam and vortioxetine group. However, the total seizure score of the vortioxetine group was not statistically significant compared to the control group. Conclusion: Vortioxetine has the potential to be clinically useful in treating epilepsy. Further detailed studies using other animal models and in humans are required to prove its efficacy in epilepsy.


Cite this article:
Sharath Kumar C, Navin Patil, Amrita Parida, Kabirdev, Prachi Priyadarshini, Shanti Gurung, Karthik Rao N , Manju V. Effect of Vortioxetine on Maximal electroshock (MES) induced seizures in Sprague Dawley rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4337-0. doi: 10.52711/0974-360X.2021.00753

Cite(Electronic):
Sharath Kumar C, Navin Patil, Amrita Parida, Kabirdev, Prachi Priyadarshini, Shanti Gurung, Karthik Rao N , Manju V. Effect of Vortioxetine on Maximal electroshock (MES) induced seizures in Sprague Dawley rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4337-0. doi: 10.52711/0974-360X.2021.00753   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-59


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