Author(s):
Ranjan Kumar Giri, Sunil Kumar Kanungo, Saroj Kumar Patro, Minaketan Sahoo, Dibya Sundar Panda
Email(s):
ranjanrifampin@gmail.com
DOI:
10.52711/0974-360X.2021.00749
Address:
Ranjan Kumar Giri1*, Sunil Kumar Kanungo1, Saroj Kumar Patro1, Minaketan Sahoo1, Dibya Sundar Panda2
1Institute of Pharmacy and Technology, Salipur, Cuttack – 754202, India.
2College of Pharmacy, Jouf University- 72341, Kingdom of Saudi Arabia.
*Corresponding Author
Published In:
Volume - 14,
Issue - 8,
Year - 2021
ABSTRACT:
Lipid lowering effect of polyherbal formulations using eight different plants was evaluated in triton and diet induced hyperlipidemic models of wistar albino rats. Formulations such as Tablet, Syrup and Suspension inhibited the elevation in serum cholesterol and triglyceride levels on Triton WR 1339 administration rats. The formulations at the same dose level significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in high-density lipoprotein cholesterol in high-fat diet-induced hyperlipidemic rats. The standard drug Niacin showed slightly better effects. The treatment with herbal formulations produced 30-35 percentage improvement in oral glucose tolerance. Similarly all the formulations also reduced the elevated C-reactive protein which is a marker of Hyperlipidemia. In histopathological study it was found that treatment of polyherbal formulation significantly reduced the plaque size in aorta compared with HFD treated control group. The outcome of the study reveals the lipid lowering activity of polyherbal formulations in dyslipidaemic conditions by interfering with the biosynthesis of cholesterol and utilization of lipids.
Cite this article:
Ranjan Kumar Giri, Sunil Kumar Kanungo, Saroj Kumar Patro, Minaketan Sahoo, Dibya Sundar Panda. Hypolipidemic effect of prepared Polyherbal formulations in Wistar albino rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4314-0. doi: 10.52711/0974-360X.2021.00749
Cite(Electronic):
Ranjan Kumar Giri, Sunil Kumar Kanungo, Saroj Kumar Patro, Minaketan Sahoo, Dibya Sundar Panda. Hypolipidemic effect of prepared Polyherbal formulations in Wistar albino rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4314-0. doi: 10.52711/0974-360X.2021.00749 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-55
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