Author(s): Ranjan Kumar Giri, Sunil Kumar Kanungo, Saroj Kumar Patro, Minaketan Sahoo, Dibya Sundar Panda

Email(s): ranjanrifampin@gmail.com

DOI: 10.52711/0974-360X.2021.00749   

Address: Ranjan Kumar Giri1*, Sunil Kumar Kanungo1, Saroj Kumar Patro1, Minaketan Sahoo1, Dibya Sundar Panda2
1Institute of Pharmacy and Technology, Salipur, Cuttack – 754202, India.
2College of Pharmacy, Jouf University- 72341, Kingdom of Saudi Arabia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
Lipid lowering effect of polyherbal formulations using eight different plants was evaluated in triton and diet induced hyperlipidemic models of wistar albino rats. Formulations such as Tablet, Syrup and Suspension inhibited the elevation in serum cholesterol and triglyceride levels on Triton WR 1339 administration rats. The formulations at the same dose level significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in high-density lipoprotein cholesterol in high-fat diet-induced hyperlipidemic rats. The standard drug Niacin showed slightly better effects. The treatment with herbal formulations produced 30-35 percentage improvement in oral glucose tolerance. Similarly all the formulations also reduced the elevated C-reactive protein which is a marker of Hyperlipidemia. In histopathological study it was found that treatment of polyherbal formulation significantly reduced the plaque size in aorta compared with HFD treated control group. The outcome of the study reveals the lipid lowering activity of polyherbal formulations in dyslipidaemic conditions by interfering with the biosynthesis of cholesterol and utilization of lipids.


Cite this article:
Ranjan Kumar Giri, Sunil Kumar Kanungo, Saroj Kumar Patro, Minaketan Sahoo, Dibya Sundar Panda. Hypolipidemic effect of prepared Polyherbal formulations in Wistar albino rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4314-0. doi: 10.52711/0974-360X.2021.00749

Cite(Electronic):
Ranjan Kumar Giri, Sunil Kumar Kanungo, Saroj Kumar Patro, Minaketan Sahoo, Dibya Sundar Panda. Hypolipidemic effect of prepared Polyherbal formulations in Wistar albino rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4314-0. doi: 10.52711/0974-360X.2021.00749   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-55


REFERENCE:
1.    Sowmya A, Ananthi T. Hypolipidemic activity of Mimosa pudica Linn on Butter Induced Hyperlipidemia in Rats. Asian Journal of Research in Pharmaceutical Sciences. 1(4); 2011: 123-126.
2.    Tiwari P. Antihyperlipidemic Potential of Balarishta Prepared by Traditional and Modern Methods in High Fat Diet Induced Hyperlipidemic rats. Asian Journal of Research in Pharmaceutical Sciences. 4(1); 2014: 07-11.
3.    Mahurkar N, Sayeed ul hasan S.M, Mutaal Quadri S. Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia. Research Journal of Pharmaceutical Dosage Forms and Technology. 7(1); 2015: 11-14.
4.    Tiwari P. Evaluation of Antihyperlipidemic Potential of Amritarishta Prepared by Traditional and Modern Methods in Hyperlipidemic Rats. Research Journal of Pharmacognosy and Phytochemistry  5(6); 2013: 315-319 .
5.     Ravindra Babu. S, Priyanka Goud. K. Evaluation of Anti-Hyperlipidemic and Antioxidant Activity of Ethanolic Extract of Delonix Elata on High fat diet Induced Rats. Research Journal of Pharmacognosy and Phytochemistry. 10(3); 2018: 241-245.
6.    Mahurkar N, ul Hasan SS, Quadri, S.M. Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia. Research Journal Pharmaceutics Dosage Forms Technology. 7 (1); 2015: 11-15.
7.    Semalty M, Kumar R, Semalty A. formulation and characterization of herbal formulation for antihyperlipidemic activity in diet induced obese mice. Indian drugs. 53(07); 2016: 07-18.
8.    Lachman L, Lieberman HA. The theory and practice of Industrial Pharmacy, 3rd edition., Varghese Publishing House, Bombay, 1990; 293-329.
9.    Khory RN. Principles and Practice of Ayurvedic Medicines, Vol.-I, Biotech Books, New Delhi. 2004; 211-219.
10.    Khanna AK, Rizivi F, Chander R. Lipid lowering activity of Phyllanthus niruri in hyperlipidemic rats. Journal of Ethnopharmacology. 82(1); 2002: 19-32.
11.    Kumar V, Singh S, Khanna AK, Khan MM, Chander R, Mahdi F, et al. Hypolipidemic activity of Athenocephalus indicus (Kadam) in hyperlipidemic rats. Medicine and Chemical Research. 17; 2008: 152-58.
12.    Vand Du V, Karr WG. Carbohydrate utilization; rate of disappearance of D-glucose from blood. Journal of BioChemistry  66; 1925: 281-300.
13.    Parekh AC, Jung DH. Cholesterol estimation with ferric acetate-uranium acetate and sulfuric acid, ferrous sulfate reagents. Analytical  Chemistry  42; 1970: 1423-1427.
14.    Rice LB. Determination of triglycerides (enzymatic method). Clinical Chemistry. 31(5); 1970: 746-750.
15.    Kallner A. Determination of phosphate in serum and urine by a single step malachite green method. Clinca Chemca Acta. 59; 1975: 35-39.
16.    Mosinger F. Photometric adaptation of Doli’s micromethod for determination of free fatty acid. Journal of Lipid Research 6; 1965: 157-160.
17.    Burstein RF, Scholnick VS. Biochemistry and methodology of lipids. Journal of Lipid Research 25; 1972: 375-382.
18.    Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measured with folin phenol reagent. Journal of Biological Chemistry; 193; 1951: 265-275.
19.    Mandukhail SR, Aziz N, Gilani AH. Studies on antidyslipidemic effect of Morinda citrifolia (Noni) fruits, leaves and root extracts. Lipids in Health and Disease 9; 2010: 88-93.
20.    Thompson D, Milford-Ward A, Whicher JT. The value of acute phase protein measurement in clinical practice. Annals of Clinical Biochemistry. 29; 1992: 123-31.
21.    Kuroda M, Tanzawa K, Tsujita Y, Endo A. Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in Triton WR-1339 induced hyperlipidemia. Biochemica Biophysica Acta. 489(1); 1977: 119-125.
22.    Schotz MC, Seanu A, Page IH. Effect of triton on lipoprotein lipase of rat plasma. American Journal of Physiology. 188(2); 1957: 399-402.
23.    Hayashi T, Ishikawa T, Naito M, Kuzuya M, Funaki C, Asai K, At Al. Low Level Hyperlipidemia Impairs Endothelium-Dependant Relaxation of Porcin Coronary Arteries By Two Mediators. Atherosclerosis. 87(1); 1991: 23-28.
24.    Nigris F de, Lerman A, Ignarro LJ, Williams-Ignarro S, Sica V, Baker AH, et al. Oxidation sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends in Molecular Medicine. 9(8); 2003: 351-359.
25.    Heuman DM, Vlahcevic ZR, Bailey ML, Hylemon PB. Regulation of bile acid synthesis. II Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rats. Hepatology 8(4); 1988: 892-897.
26.    Reusser F. Mode of action of streptozotocin. Journal of Bacteriology 105(2); 1971: 580-588.
27.    Al-Shamaony L, Al-Khazraji SM, Twaiji IA. Hypoglycemic effect of Artemisia herba alba II. Effect of valuable extract on some blood parameters in diabetic animals. Journal of Ethnopharmacology 43; 1994: 167-71.
28.    Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation  107; 2003: 363-9.
29.    Paffen E, DeMaat MP. C-reactive protein in atherosclerosis: A causal factor. Cardiovascular Research 71; 2006: 30-9.
30.    Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. American Journal of Medicine. 116; 2004: 9S-16S.
31.    Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. New England Journal of Medicine. 347; 2002: 1557-65.
32.    Chun OK, Chung SJ, Claycombe KJ, Song WO. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. Journal of Nutrition 138; 2008: 753-60.
33.    Acharyya S, Dash GK, Pattnaik S, Chhetree RR. Antihyperglycemic and Antihyperlipidemic Activity of Acacia suma (Roxb.) Barks. Research Journal Pharmacology and Pharmacodynamics. 3(2): 2011; 67-71.
34.    Murti K, Panchal M, Shah M, Lambole V. Antidiabetic and Antihyperlipidemic Activity of Roots of Matricaria recutita on Streptozotocin-Induced Diabetic Rats. Research Journal of Pharmacology and Pharmacodynamics. 3(4): 2011; 180-183.
35.    Shah Urvi S, Patel KN. Protective effects of Strychnos potatorum Linn. seeds extract in hyperlipidemic rat model. Research Journal of Pharmacology and Pharmacodynamics. 4(4): 2012; 213-217.
36.    Tiwari P, Patel R K. Evaluation of Antihyperlipidemic Potential of Drakshasava Prepared by Traditional and Modern Methods in Hyperlipidemic Rats. Research Journal of Pharmacology and Pharmacodynamics. 5(2): 2013; 92-97.
37.    Srikanth J, Muralidharan P. Antihyperlipidemic activity of Sapindus emarginatus in Triton WR-1339 induced albino rats. Research Journal of Pharmacy and Technology. 2(2): 2009; 319-323.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available