Vipul Kumar, Sudhakar Kancharla, Manoj Kumar Jena
Vipul Kumar1, Sudhakar Kancharla2, Manoj Kumar Jena3*
1Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India.
2Devansh Lab Werks, 234 Aquarius Drive, Homewood, Alabama, USA 35209.
3Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India.
Volume - 14,
Issue - 8,
Year - 2021
Since the outbreak of severe acute respiratory syndrome corona Virus -2 (SARS-CoV-2) has happened in December 2019 in Wuhan, China, the cases of novel coronavirus disease (COVID-19) is rapidly increasing worldwide. In the absence of specific drugs against COVID-19, the fast and reliable choice would be repurposing of existing drugs. Here, we have chosen one of the crucial enzymes of the SARS-CoV-2, Papain like protease (PLpro) and its mutant C111S for the structure-based in-silico screening of the FDA approved drugs. Firstly, the alignment of the wild type and mutant PLpro was done, and no significant change in the global structure was observed. Then based on the docking study, we have reported the best 3 compounds against a mutant and wild type PLpro. These lead compounds include amikacin and mafenide, which are well-known antibiotics. The binding affinity, as well as number of polar and non-polar interactions, indicates their potential against the PLpro. This computational study strongly suggests the experimental validations of the predicted compounds for a confident claim.
Cite this article:
Vipul Kumar, Sudhakar Kancharla, Manoj Kumar Jena. In silico screening of FDA approved drugs predicts the therapeutic potentials of Antibiotic drugs against the papain like protease of SARS-CoV-2. Research Journal of Pharmacy and Technology. 2021; 14(8):4035-9. doi: 10.52711/0974-360X.2021.00699
Vipul Kumar, Sudhakar Kancharla, Manoj Kumar Jena. In silico screening of FDA approved drugs predicts the therapeutic potentials of Antibiotic drugs against the papain like protease of SARS-CoV-2. Research Journal of Pharmacy and Technology. 2021; 14(8):4035-9. doi: 10.52711/0974-360X.2021.00699 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-5
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