Author(s): A. Anka Rao, Swarupa Arvapalli, G. S. N. Koteswara Rao, Narender. Malothu, Naga Raju. Bandaru

Email(s): drankarao83@gmail.com

DOI: 10.52711/0974-360X.2021.00724   

Address: Dr. A. Anka Rao1*, Swarupa Arvapalli2, Dr. G. S. N. Koteswara Rao1, Narender. Malothu1, Naga Raju. Bandaru1
1K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, India - 522 502.
2Research Scholar, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, India - 522 502.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
The current study aims to formulate and evaluate acyclovir loaded niosomes for sustained release of acyclovir. Stable Acyclovir loaded Niosomes can be prepared by hand shaking method and ether injection method with Span 80 and cholesterol in the ratio of 1:1, 2:1, and 3:1. Preformulation studies and drug excipients compatibility studies was done initially and results directed the further course of formulation. Most of the vesicles are spherical in shape, the size range of the vesicles, fall in the narrow size range of 0.5-5? and 0.5-2.5? by hand shaking method and ether injection method respectively. A high % of Acyclovir can be encapsulated in the vesicles (75-84%) prepared by hand shaking method. Concentration of non-ionic surfactant such as Span 80 might influences the drug release pattern of all formulation. In vitro release of Acyclovir from niosomes was very slow when compared to the release from pure Acyclovir solution. Drug release studies showed that the niosomal preparation was stable at refrigeration temperature (40C). The vesicles prepared by hand shaking method were found to be larger in size as compared to vesicles prepared by ether injection method. Almost constant drug release was observed in all formulations indicating zero order release pattern.


Cite this article:
A. Anka Rao, Swarupa Arvapalli, G. S. N. Koteswara Rao, Narender. Malothu, Naga Raju. Bandaru. Design and Evaluation of Acyclovir Niosomes. Research Journal of Pharmacy and Technology. 2021; 14(8):4185-8. doi: 10.52711/0974-360X.2021.00724

Cite(Electronic):
A. Anka Rao, Swarupa Arvapalli, G. S. N. Koteswara Rao, Narender. Malothu, Naga Raju. Bandaru. Design and Evaluation of Acyclovir Niosomes. Research Journal of Pharmacy and Technology. 2021; 14(8):4185-8. doi: 10.52711/0974-360X.2021.00724   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-30


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