Author(s): Ali G. Abdullah, Ban I. Sedeeq, Marwan S. Azzubaidi


DOI: 10.52711/0974-360X.2021.00697   

Address: Ali G. Abdullah1, Ban I. Sedeeq2, Marwan S. Azzubaidi3*
1Department of Oral and Maxillofacial Surgery, College of Dentistry, Tikrit University, Iraq.
2Department of Basic Sciences, College of Dentistry, Tikrit University, Iraq.
3Pharmacology Unit, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021

Coenzyme Q10 (Co-Q10) or ubiquinone plays an important role in the cellular metabolism. The safety profile of ubiquinone as a dietary supplement has been assessed in few sub-chronic toxicity studies. The aim of this study was to evaluate the possible hepatotoxic effect of long-term oral administration of an intermediate oral dose of Co-Q10 in experimental animals. Fifteen Wistar rats were treated with 300mg/kg daily oral doses of Co-Q10 using forced oral feeding for six weeks. Additional 5 healthy rats represented the control group for comparison. All rats were euthanized at the end of the 6th week. Then H and E stained histological sections of rats’ livers revealed vacuolation of hepatocytes, an increase in the diffusion of macrophages and the formation of microgranuloma most probably indicating a drug-induced injury. In conclusion, this study adds evidence supporting the potential hepatotoxic actions resulting from repeated administration of intermediate oral dose of Co-Q10 especially on the long-term.

Cite this article:
Ali G. Abdullah, Ban I. Sedeeq, Marwan S. Azzubaidi. Histopathological Changes in Liver Tissue after repeated administrations of an Intermediate Dose of Coenzyme Q10 to Wistar Rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4025-8. doi: 10.52711/0974-360X.2021.00697

Ali G. Abdullah, Ban I. Sedeeq, Marwan S. Azzubaidi. Histopathological Changes in Liver Tissue after repeated administrations of an Intermediate Dose of Coenzyme Q10 to Wistar Rats. Research Journal of Pharmacy and Technology. 2021; 14(8):4025-8. doi: 10.52711/0974-360X.2021.00697   Available on:

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