Author(s): Anna Buzlama, Solaiman Doba, Sali Daghir, Karpova Evgenija Leonidovna, Ghadeer Balloul

Email(s): silversleman23@gmail.com

DOI: 10.52711/0974-360X.2021.00710   

Address: Anna Buzlama1, Solaiman Doba1*, Sali Daghir2, Karpova Evgenija Leonidovna1, Ghadeer Balloul3
1 Department of Pharmacology and Clinical Pharmacology, Faculty of Pharmacy, Voronezh State University, Russia.
2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Tishreen University, Latakia, Syria.
3Department of Pharmaceutical Technology, Faculty of Pharmacy, Belgorod State National Research University, Russia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
In this study, the antiulcer activity of a gel based on high-viscosity chitosan was studied in models of NSAID and ethanol-induced ulcerogenesis. To simulate damage to the gastric mucosa in the NSAID model, diclofenac sodium was administered to experimental animals at a dose of 50mg/kg. An antiseptic intestinal and astringent agent was chosen as reference drug: bismuth tripotassium dicitrate at a dose of 0.017g/kg. The studied gel was used in 3 doses (0.08, 0.16 and 0.24ml/100g of body weight). In ethanol model, ulcers were induced by a single administration of ethanol 96% at a dose of 5ml/kg. Omeprazole at a dose of 20mg/kg was used as reference drug in this model. Chitosan-based gel was administrated in this model at a dose of 0.16ml per 100g of animals, which corresponds to the minimum available dose with antiulcer activity in the NSAID model. All investigated substances were injected intragastrically using a gastric tube. As a result of this research, it was found that the chitosan-based gel is effective in the NSAID gastropathy model but not effective in the ethanol model. In the NSAID gastropathy model, after a single oral administration of chitosan-based gel at doses of 0.16 and 0.24ml/ 100g, sufficient antiulcer activity was revealed, which was 2.4 and 4.694, respectively, and exceeded the effect of the reference drug, bismuth tripotassium dicitrate. In the ethanol model, the results of experimental studies showed that the reference drug, omeprazole, provides antiulcer activity with a calculated value of the antiulcer activity index of 2.18. After the administration of a chitosan-based gel at a dose of 0.16 ml per 100g of body weight of animals, compared with the control, the calculated value of antiulcer activity was 1.18, which characterizes the absence of an antiulcer effect.


Cite this article:
Anna Buzlama, Solaiman Doba, Sali Daghir, Karpova Evgenija Leonidovna, Ghadeer Balloul. Study of Antiulcer activity of a hydrogel based on chitosan. Research Journal of Pharmacy and Technology. 2021; 14(8):4101-6. doi: 10.52711/0974-360X.2021.00710

Cite(Electronic):
Anna Buzlama, Solaiman Doba, Sali Daghir, Karpova Evgenija Leonidovna, Ghadeer Balloul. Study of Antiulcer activity of a hydrogel based on chitosan. Research Journal of Pharmacy and Technology. 2021; 14(8):4101-6. doi: 10.52711/0974-360X.2021.00710   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-16


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