Author(s): Karpakavalli M, Sangilimuthu AY, Komala M, Nagaraja Perumal G, Mohan S, Sivakumar T


DOI: 10.52711/0974-360X.2021.00704   

Address: Karpakavalli M1*, Sangilimuthu AY2, Komala M3, Nagaraja Perumal G4, Mohan S5, Sivakumar T6
1Dept. of Pharmaceutical Chemistry, Karpagam College of Pharmacy, Coimbatore - 641032. Tamil Nadu, India.
2Dept. of Biotechnology, Karpagam University, Coimbatore - 641021. Tamil Nadu, India.
3Dept. of Pharmaceutics, Vel’s Institute of Science, Technology and Advanced Studies, Chennai - 600117, Tamil Nadu, India.
4Dept. of Pharmacology, Sree Abirami College of Pharmacy, Coimbatore, Tamil Nadu, India.
5Dept. of Pharmaceutics, Karpagam College of Pharmacy, Coimbatore - 641032, Tamil Nadu, India.
6Dept. of Pharmaceutical Chemistry, Nanda College of Pharmacy, Perundurai - 638052, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021

Objective: The synthesized compounds of 2’’,4’’-thiazolidindione derivatives of 7-flavonols*, after characterization, aimed to be tested for their anti-oxidant and anti-microbial effects. Methods: i) Free radical scavenging actions tested by hydrogen peroxide- nitric oxide- and by alkaline DMSO- methods and ii) anti-microbial effects against various bacterial pathogens and against candida albicans by disc diffusion method. Results: Data were found to be dose dependent and IC50 value was 30-60 µg/ml and the results revealed that the dinitro-, trinitro- and acetyl, dinitro derivatives showed better and/or equipotent activity to that of the standard, ascorbic acid. The synthesized compounds exerted variable inhibitory activities at a concentration of 1µg /10µl /disc with inhibition zone ranging from 7-26 mm in diameter and a good antifungal activity against Candida albicans at the concentration of (1µg /10µl /disc) with inhibition of 10-24 mm. Klebsiella tribatta are more susceptible to the action of the formylated samples, giving high inhibition values comparing to the other organisms. Compounds Ie and Ih resulted to a higher activity index (AI>1); compounds Id, Ig and Ii showed an equal value (AI=1); whereas, Ia, Ib, Ic and If showed only a moderate activity (AI<1) compared to the standard, Amikacin. Conclusion: The findings confirmed that the synthetic compounds of 3-formyl, 7-flavonol derivatives have significant anti-oxidant and anti-microbial activities.

Cite this article:
Karpakavalli M, Sangilimuthu AY, Komala M, Nagaraja Perumal G, Mohan S, Sivakumar T. Anti-oxidant and Anti-microbial activities of 2’’, 4’’-thiazolidindione derivatives of 7-flavonols. Research Journal of Pharmacy and Technology. 2021; 14(8):4067-6. doi: 10.52711/0974-360X.2021.00704

Karpakavalli M, Sangilimuthu AY, Komala M, Nagaraja Perumal G, Mohan S, Sivakumar T. Anti-oxidant and Anti-microbial activities of 2’’, 4’’-thiazolidindione derivatives of 7-flavonols. Research Journal of Pharmacy and Technology. 2021; 14(8):4067-6. doi: 10.52711/0974-360X.2021.00704   Available on:

1.    Cotelle N, Brenier JL, Henichart JP, Catteau JP, Gyadou E and Wallet JC. Scavenger     and antioxidant properties of ten synthetic flavones. Free Radical Biological Medicine. 1992; 13: 211-219.
2.    Bhawya Dayananda, Anilakumar KR, Farhath Khanum and Bawa Amarinder Singh. Invitro antioxidant and free radicals scavenging activity of Glycyrrhiza glabra root extracts. Journal of Herbal Medicine and toxicology. 2010; 4(1): 97-102.
3.    Yadunath M Joshi, Vilasrao J Kadam and Prashant R Kaldhone. Invitro antioxidant activity of methanolic extract of Aerial Parts of Canna indica Linn. Journal of Pharmaceutical Research.2009; 2(11): 1712-1715.
4.    Kalpesh Gour, Kori ML, Tyagi LK, Nema RK, Sharma CS and Priyanka Tripathi. In vitro antioxidant activity of Ipomonea fistulosa Linn. Academic journal of plant sciences. 2009; 2(2): 60-64.
5.    Lavhale MS and Mishra HS. Evaluation of free radical scavenging activity of Butea monosperma lam. Indian journal of Experimental Biology. 2007; 45: 376-384.
6.    Miller AL. Antioxidant flavonoids: structure, function and clinical usage. Alternate Medical Reviews, 1996; 1: 103-111.
7.    Karpakavalli M, Sivakumar T. Synthesis, Characterization and Pharmacological Activities of 7- Flavonol Derivatives obtained by an Expeditious Coupling Technique of Microwave Irradiations and Ionic Liquid, Asian Journal of Research in Chemistry, 2014; 7(2): 148-158.
8.    Vuillaume M.Reduced oxygen species, mutation, induction and cancer initiation. Mutation Research. 1987; 186: 43-72.
9.    AliSS, Kasoju N, Luthra A, Singh A, Sharanabasava H, Sahu A and Bora U. Indian medicinal herbs as sources of Antioxidants. Food Research International. 2008; 41: 1-15.
10.    Pasha FA, Cho SJ, Beg Y and Tripathi YB. Quantum chemical QSAR study of flavones and their radical scavenging activity. Medicinal Chemistry Research. 2008; 16: 408-417.
11.    Ray S, Sengupta C and Roy K. QSAR modeling of antiradical and antioxidant activities of flavanoids using electrotopological state (E-state) atom parameters. European Journal of Chemistry. 2007; 5: 1094-1113.
12.    Sarkar A, Middya TR and Jana AD. A QSAR study of radical scavenging antioxidant activity of a series of flavanoids using DFT based quantum chemical descriptors-The importance of group frontier electron density. Journal of Molecular Model. 2011; 18: 2621-2631.
13.    M. Karpakavalli, A.Y. Sangilimuthu, Usha Raja Nanthini, G.Nagaraja Perumal, S. Mohan and T. Sivakumar. Anti-Inflammatory Effects of 3-Formyl, 7-Flavonols Derivatives by Microwave Enhanced Chemistry Assisted - Vilsmeier Haack synthesis. Biomedical and amp; Pharmacology Journal, 2019, 12(4), 1779-1791.
14.    Lassegue and Griendling KK. Reactive oxygen species in hypertension: an update. American Journal of Hypertension. 2004; 17 (9): 852–860.
15.    Terao J, Piskula M and Yao Q. Protective effect of epicatechin, epicatechin gallate and quercetin on lipid peroxidation in phospholipid bilayers.  ActaBiochemistry and Biophysics. 1994; 308: 278-284.
16.    Scott R and Slatter TF. Free radical scavenging activity of (+) catechin and other flavanoids. 1981; 233-244.
17.    Robak J and Gryglewski RJ. Flavanoids are scavengers of superoxide anion. Biochemistry and Pharmacology. 1988; 37: 837-841.
18.    Cushnie TPT and Lamb AJ. Antimicrobial activity of flavanoids. International Journal of Anti-microbials Agents. 2005; 26:343-356.
19.    Vaquero MJR, Alberto MR and De Nadra MCM. Antibacterial effect of phenolic compounds from different wines. Food control.2007; 18:93-101.
20.    Teffo L, Aderogba M and Eloff J. Antibacterial and antioxidant activities of four kaempferol methyl ethers isolated from Dodonaea viscose leaf extracts, South African Journal of Botany. 2010; 76: 25-29.
21.    Demetzos et al., Structure elucidation, conformational analysis and thermal effects on membrane bilayers of an antimicrobial myricetin ether derivative. Journal of Heterocyclic Chemistry. 2001; 38: 703-710.
22.    HarborneJB and Williams CA. Advances in flavonoid research since 1992. Phytochemistry. 2005; 55: 481–504.
23.    Rauha JP, Remes S, Heinonen M, Hopia A, Kahkonen and Kujala M. Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. International Journal of Food and Microbiology. 2000; 56: 3-12.
24.    Vardar-Unlu G, Candan F, Sokmen A, Daferera D, Polissiou M and Sokmen M.   Antimicrobial and antioxidant activity of the essential oil and methanol extracts of Thymus Pectinatus fisch. et mey. Var. pectinatus (Lamiaceae).Journal of Agricultural Food Chemistry. 2003; 50: 63–67.
25.    Chacha M, Gojase-Moletta G and Majinda RRT. Antimicrobial and radical scavenging flavonoids from the stem wood of Erithrina latissima. Phytochemistry. 2005; 66: 99-104.
26.    Collins CH. Antibiotics and Antibacterial substances: Microbiological methods, (Butterworths London), 1964; 296.
27.    Philips OA, Udo EE, Abdel ME and Varghese R. Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole)methyl oxazolidinediones. European Journal of Medicinal Chemistry. 2009; 448: 3217-3227.
28.    Gadaginamath SG and Patil AS. Synthesis and antimicrobial activity of some new 2-amino-methyl-5-(4-phenyl-mercapto-1,2,4-triazole-3-yl) methoxyindole derivatives. Indian Journal of Chemistry. 1999; 38B: 1070-1074.
29.    Shukla DK and Srivastava SD. Synthesis of some new 5[2-{(1,2,3-benzotriazole)-1-yl-methyl}-1’-(4’-substituted aryl-3’-chloro-2’-oxo azetidine)}-amino-1,3,4-thiadiazoles; Antifungal and antibacterial agents. Indian Journal of Chemistry. 2008; 47B:463-469.
30.    Bhusare RS, Shinde BA, Pawar PR and Vibhute BY. Synthesis and antimicrobial activity of heterocyclic Schiff bases, 4-thaizolidinediones and 2-azetidinones, Indian Journal of Pharmaceutical Sciences. 2004; 3: 228-231.
31.    De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A and Nair GB. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrobial Agents Chemotherapy. 2009; 53: 1592-97.

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