Author(s): Karpakavalli M, Sangilimuthu AY, Komala M, Nagaraja Perumal G, Mohan S, Sivakumar T

Email(s): sreemenakag@gmail.com

DOI: 10.52711/0974-360X.2021.00704   

Address: Karpakavalli M1*, Sangilimuthu AY2, Komala M3, Nagaraja Perumal G4, Mohan S5, Sivakumar T6
1Dept. of Pharmaceutical Chemistry, Karpagam College of Pharmacy, Coimbatore - 641032. Tamil Nadu, India.
2Dept. of Biotechnology, Karpagam University, Coimbatore - 641021. Tamil Nadu, India.
3Dept. of Pharmaceutics, Vel’s Institute of Science, Technology and Advanced Studies, Chennai - 600117, Tamil Nadu, India.
4Dept. of Pharmacology, Sree Abirami College of Pharmacy, Coimbatore, Tamil Nadu, India.
5Dept. of Pharmaceutics, Karpagam College of Pharmacy, Coimbatore - 641032, Tamil Nadu, India.
6Dept. of Pharmaceutical Chemistry, Nanda College of Pharmacy, Perundurai - 638052, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 8,     Year - 2021


ABSTRACT:
Objective: The synthesized compounds of 2’’,4’’-thiazolidindione derivatives of 7-flavonols*, after characterization, aimed to be tested for their anti-oxidant and anti-microbial effects. Methods: i) Free radical scavenging actions tested by hydrogen peroxide- nitric oxide- and by alkaline DMSO- methods and ii) anti-microbial effects against various bacterial pathogens and against candida albicans by disc diffusion method. Results: Data were found to be dose dependent and IC50 value was 30-60 µg/ml and the results revealed that the dinitro-, trinitro- and acetyl, dinitro derivatives showed better and/or equipotent activity to that of the standard, ascorbic acid. The synthesized compounds exerted variable inhibitory activities at a concentration of 1µg /10µl /disc with inhibition zone ranging from 7-26 mm in diameter and a good antifungal activity against Candida albicans at the concentration of (1µg /10µl /disc) with inhibition of 10-24 mm. Klebsiella tribatta are more susceptible to the action of the formylated samples, giving high inhibition values comparing to the other organisms. Compounds Ie and Ih resulted to a higher activity index (AI>1); compounds Id, Ig and Ii showed an equal value (AI=1); whereas, Ia, Ib, Ic and If showed only a moderate activity (AI<1) compared to the standard, Amikacin. Conclusion: The findings confirmed that the synthetic compounds of 3-formyl, 7-flavonol derivatives have significant anti-oxidant and anti-microbial activities.


Cite this article:
Karpakavalli M, Sangilimuthu AY, Komala M, Nagaraja Perumal G, Mohan S, Sivakumar T. Anti-oxidant and Anti-microbial activities of 2’’, 4’’-thiazolidindione derivatives of 7-flavonols. Research Journal of Pharmacy and Technology. 2021; 14(8):4067-6. doi: 10.52711/0974-360X.2021.00704

Cite(Electronic):
Karpakavalli M, Sangilimuthu AY, Komala M, Nagaraja Perumal G, Mohan S, Sivakumar T. Anti-oxidant and Anti-microbial activities of 2’’, 4’’-thiazolidindione derivatives of 7-flavonols. Research Journal of Pharmacy and Technology. 2021; 14(8):4067-6. doi: 10.52711/0974-360X.2021.00704   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-8-10


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