Author(s): Suraj B. Pund, Vishwas C. Bhagat, Madhuri T. Deshmukh, Deepak P. Kardile, Rajkumar V. Shete


DOI: 10.52711/0974-360X.2021.00691   

Address: Suraj B. Pund*, Vishwas C. Bhagat, Madhuri T. Deshmukh, Deepak P. Kardile, Rajkumar V. Shete
Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Dist - Pune - 412206, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021

The objective of writing this review on Floating Drug Delivery Systems (FDDS) was to accumulate new work with a special focus on the primary floatation mechanism for gastric retention. Drug delivery systems are those that instantly float on contact with gastric fluids and present promising approaches to improve the bioavailability of drugs with absorption windows in the stomach or upper small intestine, imbalanced in the intestinal or colonic environment, and exhibit low solubility at high pH standards. It is a novel drug delivery system that takes full advantage of effectiveness and compliance. Physical problems such as short gastric residence time and unpredictable gastric emptying time were overcome with the use of floating dosage forms that provide the possibility of local and systemic effects. The floating drug delivery system allows prolonged and continuous entry of the drug into the upper part of the gastric retention pathway and increases the bioavailability of the medication characterized by a narrow absorption window. This review provides detailed information on the pharmaceutical basis of its Introduction, Advantages, Disadvantages, Factors Affecting Gastric Emptying, and Criteria for Suitable Drug Products for Floating Gastric-Retention, Classification of Floating Multiparticulate Drug Delivery System, and Characterization of Floating Multiparticulate Drug Delivery System. These systems are beneficial for various difficulties encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. This review article has attempted to announce to readers about the floating drug delivery system.

Cite this article:
Suraj B. Pund, Vishwas C. Bhagat, Madhuri T. Deshmukh, Deepak P. Kardile, Rajkumar V. Shete. A Review on Floating Multi-particulate Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(7):3987-2. doi: 10.52711/0974-360X.2021.00691

Suraj B. Pund, Vishwas C. Bhagat, Madhuri T. Deshmukh, Deepak P. Kardile, Rajkumar V. Shete. A Review on Floating Multi-particulate Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(7):3987-2. doi: 10.52711/0974-360X.2021.00691   Available on:

1.    Shah S, Pandya S. IJPSR (2010), Vol. 1, Issue 6 (Review Article). 2010; 1(6): 7-18.
2.    Arora S. Floating Drug Delivery Systems: A Review. Am Assoc Pharm Sci. 2005; 6(3): E373-90.
3.    Avaru Geetha Dutt et al. Formulation and Evaluation of Gastro Retentive Drug Delivery System of Tizanidine Hydrochloride: A Review. Int Res J Pharm. 2014; 3(10): 34-45.
4.    Jain SK, Awasthi AM, Jain NK, Agrawal GP. Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: Preparation and in-vitro characterization. J Control Release. 2005; 107(2): 300-9.
5.    Kumar R, Kamboj S, Chandra A, Gautam PK, Sharma VK. Microballoons: An Advance Avenue for Gastroretentive Drug Delivery System- A Review. UK J Pharm Biosci. 2016; 4(4): 29.
6.    Ch’Ng HS, Park H, Kelly P, Robinson JR. Bioadhesive polymers as platforms for oral controlled drug delivery II: Synthesis and evaluation of some swelling, water‐insoluble bioadhesive polymers. J Pharm Sci. 1985; 74(4): 399-405.
7.    Yie W. Chein et al.  London; 2014; 149-151 p.
8.    Samyuktha Rani B, Vedha Hari BN, Brahma Reddy A, Punitha S, Devi P, Rajamanickam V. The recent developments on gastric floating drug delivery systems: A overview. Int J Pharm Tech Res. 2010; 2(1): 524-34.
9.    Arunachalam A, Karthikeyan M, Kishore K, Pottabathula PH, Sethuraman S, Ashutosh Kumar S, et al. A review on floating drug delivery systems. Float drug Deliv Syst A Rev. 2011; 2(1): 76-83.
10.    Narang N. An updated review on: Floating drug delivery system (FDDS). Int J Appl Pharm. 2011; 3(1): 1-7.
11.    Pooja Gupta, Gnanarajan, Kothiyal P. Floating drug delivery system- A review. Int J Pharma Res Rev. 2015; 4(8): 37-44.
12.    Adarsh M, Sunil PH, Kanna P, Sampath M. International Journal of Research in Design formulation and evaluation of gastroretentive floating tablets of stavudine. 2017; 6(1): 93-103.
13.    Chukka S, M S, Puligilla S. Ournal of Pharma Research. Asian J Chem. 2014; 26(12): 70-3.
14.    Adibkia K, Ghanbarzadeh S, Mohammadi G, Atashgah RB, Sabzevari A. Gastro retentive drug delivery systems: A review. J Reports Pharm Sci. 2013; 2(2): 190-204.
15.    Khosla R, Davis SS. The effect of tablet size on the gastric emptying of non-disintegrating tablets. Int J Pharm. 1990; 62(2-3): R9.
16.    Timmermans J, Moës AJ. Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: New data for reconsidering the controversy. J Pharm Sci. 1994;83(1):18–24.
17.    O’Reilly S, Wilson CG, Hardy JG. The influence of food on the gastric emptying of multiparticulate dosage forms. Int J Pharm. 1987; 34(3): 213-6.
18.    Abrahason B, Alpsten M, Hugosson M, Jonsson UE, Sundgren M, Svenheden A, et al. Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended-Release (ER) Tablets. Vol. 10, Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 1993. p. 709-14.
19.    Kaus LC, Fell JT, Sharma H, Taylor DC. the influence of metoclopramide. 1984; 22: 99-103.
20.    Coupe AJ, Davis SS, Evans DF, Wilding IR. Nocturnal scintigraphic imaging to investigate the gastrointestinal transit of dosage forms. J Control Release. 1992; 20(2): 155-62.
21.    Lopes CM, Bettencourt C, Rossi A, Buttini F, Barata P. Overview on gastroretentive drug delivery systems for improving drug bioavailability. Int J Pharm [Internet]. 2016; 510(1): 144-58. Available from:
22.    Chavanpatil MD, Jain P, Chaudhari S, Shear R, Vavia PR. Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. Int J Pharm. 2006; 316(1-2): 86-92.
23.    Pare A YS and PU. Formulation and Evaluation of Effervescent Floating Tablet of Amlodipine besylate. Res J Pharm Tech. 2008; 1(4): 226-30.
24.    Mantry S, Thilothama LR, Shashanka D. Formulation and in-vitro evaluation of metoprolol succinate floating tablets by using two viscosity grade of HPMC. Int J Pharm Sci Res [Internet]. 2012; 3(9): 3507-13. Available from: Vol. 3 (9), Sept. 2012, IJPSR-1915, Paper 87.pdf
25.    Pujari PS, Uttekar PS, Chaudhari PD, Bamane PS. Formulation development and evaluation of bilayer floating tablet of antidiabetic drugs. Der Pharm Lett. 2016; 8(21): 34-54.
26.    Yadav VD, Babar SA, Satheshkumar S, Shanmugasundaram P. Formulation and evaluation of floating beads of Norfloxacin. IOSR J Pharm. 2016; 6(9): 07-13.
27.    Ar S, Narasimharaj A. Design and development of floating gel beads of levodopa. 2018; 4(3): 167-78.
28.    P.A D, Maria Stanley T, Raj R P. Formulation and evaluation of floating beads of esomeprazole magnesium USP. Int J Pharm Chem Anal. 2019; 6(2): 40-3.
29.    Patil D, Malpure P. Formulation and Evaluation of Gastroretentive Floating Alginate Beads of Lafutidine By Ionotropic. World J Pharm Res. 2016; 5(7): 1070-86.
30.    Ghareeb MM, Radhi ZA. Academic Science s. 2014; 6(2): 2-6.
31.    Rathore M, Shriwas S, Dwivedi S, Dubey R. AJMPR Formulation and Evaluation of Glycyrrhizin Alginate Beads for Stomach-Specific Delivery. 2017; 7(1): 6-8.
32.    Parsekar SD, Prabhu S, Shetty A, Azharuddin M, Shabaraya AR. Review Article A Brief Review on Floating Bilayer Tablet as a Convenient Gastroretentive Drug Delivery System. 2014; 3(2): 420-30.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available