Author(s):
Bhupendra Singh, Pooja Sharma, Sujit Bose, Jyoti Thakur, Geetanjali Saini, Manish Vyas
Email(s):
poojasharma195106@gmail.com
DOI:
10.52711/0974-360X.2021.00687
Address:
Bhupendra Singh1, Pooja Sharma1*, Sujit Bose2, Jyoti Thakur1, Geetanjali Saini1, Manish Vyas2
1Abhilashi College of Pharmacy, Nerchowk, Mandi H.P, India.
2Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Phagwara, P.B.
*Corresponding Author
Published In:
Volume - 14,
Issue - 7,
Year - 2021
ABSTRACT:
There are many problems with the conventional dosage form of various drugs and one of them is dosing frequency in which patients have to take the drug again and again throughout the day which is very difficult mainly for the elder patient. So, to overcome this problem the approach of a novel drug delivery system (NDDS) is used to replace the conventional drug delivery system. NDDS mainly deals with sustained release of drugs which is effective to reduce the dosing frequency. Niosome is one of the best approaches of a novel drug delivery system, in which the drug in solution form is enclosed in vesicle which is made up of non-ionic surfactants. In the case of liposome which is another part of NDDS vesicles is made up of phospholipids. Niosome formulation is a powerful tool to resolve the issue of insolubility and the low bioavailability of drugs. This paper overviews the various methods of preparation of Niosome along with its pharmaceutical applications.
Cite this article:
Bhupendra Singh, Pooja Sharma, Sujit Bose, Jyoti Thakur, Geetanjali Saini, Manish Vyas. Niosomes: The Current and Future perspectives in Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(7):3961-6. doi: 10.52711/0974-360X.2021.00687
Cite(Electronic):
Bhupendra Singh, Pooja Sharma, Sujit Bose, Jyoti Thakur, Geetanjali Saini, Manish Vyas. Niosomes: The Current and Future perspectives in Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(7):3961-6. doi: 10.52711/0974-360X.2021.00687 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-84
REFERENCES:
1. Breimer DD and Speiser R. Topics in Pharmaceutical Sciences. Elsevier Science Publishers, New York, USA. 1985; 291.
2. Uchegbu I.F, Florence A.T Nonionic surfactant vesicles (Niosomes): Physical and Pharmaceutical Chemistry. Advances in Colloid and Interface Science.1995; 58: 1-55.
3. Fang J.Y. et al., Characterisation and stability of various liposomes –encapsulated enoxacin formulations. Chem. Pharm Bull.2001; 45: 1504-1509.
4. Kamath M.P. et al., Indian Journal of. Experimental Biology, 2000; 32(2): 113- 118.
5. Naresh RAR. et al., Kinetics and Tissue Distribution of Niosomal Bleomycin in Tumor Bearing Mice. Indian Journal of Pharmaceutical Sciences.1996; 230.
6. Reddy DN and Udupa N. Formulation and Evaluation of Oral and Transdermal Preparation of Flurbiprofen and Piroxicam Incorporated with Different Carriers. Drug Development in Indian Pharmaceuticals. 1993; 843.
7. Satturwar P M. Formulation and Evaluation of Ketoconazole Niosomes. Indian Journal of Pharmaceutical Science. 2002; 155.
8. Shahiwala A and Misra A. Studies in Topical Application of Niosomally Entrapped Nimesulide. Journal of Pharmaceutical Sciences. 2002; 220.
9. Handjani-vila RM: Dispersion of lamellar phases of nonionic lipids in cosmetic products. International Journal of Cosmetic Sciences.1979;1: 303
10. Mehta A: Niosomes. www.pharmainfo.net. 2009
11. Chauhan S. and Luorence M.J. The preparation of polyoxyethylene containing nonionic surfactant. vesicles. Journal of Pharmaceutical Pharmacology. 1989; 41: 6.
12. Bhaskaran S and Panigrahi L. Formulation and Evaluation of Niosomes using Different Nonionic Surfactants. Indian Journal of Pharmaceutical Sciences. 2002; 63.
13. A Rogerson; J Cummings; N Willmott; AT Florence. Journal of Pharmaceutical Pharmacology. 1998; 40(5): 337–342.
14. AJ Baillie, GH Coombs, TF Dolan. Journal of Pharmaceutical Pharmacology. 1986;38: 502-505.
15. Arunothayanun P., Turton J. A., Uchegbu I. F., Florence A. T. Preparation and in vitro/in vivo evaluation of luteinizing hormone-releasing hormone (LHRH)-loaded polyhedral and spherical/tubular niosomes. Journal of Pharmaceutical Science. 1999; 88: 34-38.
16. Khandare JN, Nande VS. Niosomal delivery of ketoconozole, Indian Drugs. 2001; 38(12): 620-623.
17. Keservani R. K., Sharma A. K., Ramteke S. Novel Vesicular Approach for Topical Delivery of Baclofen via Niosomes. Lat American Journal of Pharmaceuticals. 2010;29: 1364-1370.
18. Yoshioka T, Stermberg B, Florence AT. Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60, and 80) and a sorbitantriester (Span 85). International Journal of Pharmaceuticals.1994; 105: 1-6.
19. Szoka FJR, Papahadyopoulos D. Comparative properties and methods of preparation of lipid vesicles (liposomes), Annual Review Biophysics Bioengineering.1980;9: 467-508.
20. Vyas S.P.; Singh R.P.; Jain S. et al. Formulation Development And In-Vivo Evaluation Of Zidovudine Niosomes, Indian Journal of Pharmaceuticals, 2005;296: 80-86.
21. Balasubramanium A, Dasaratha DM, Vangala AK. Formulation and In-vitro evaluation of niosomes encapsulated Daunorubicin hydrochloride, Indian Drugs. 2002; 39(1): 27-31
22. Raja Naresh R.A. Anti-inflammatory activity of Niosome encapsulated diclofenac sodium with Tween -85 in Arthritic rats. Indian Journal of Pharmacology. 1994;26: 46-48.
23. Verma Ashish Kumar et al. Indian Journal of Novel Drug Delivery. 2011;3(4): 238-239
24. Devi G. S, Venkatesh P, Udupa N. Niosomal sumatriptan succinate for nasal administration. International Journal of Pharmaceutical Sciences, 2000; 62(6): 479-481
25. B. Divya et al. In vitro drug release profile of aceclofenac niosomes formed with different ratio’s of cholesterol using sorbitan esters.
26. Popli H. and Nair. M.S et al. Niosomal delivery of Tenixicam, Indian Journal of Pharmaceutical Sciences. 1996: (163-166).
27. Alla Nasr M et al., Formulation and evaluation of topical niosomal gel of baclofen, Journal of Chemical and Pharmaceutical Research. 2015;7(1): 277-288.
28. Yongtai Zhang et al. Evaluation of transdermal salidroside delivery using niosomes via in vitrocellular uptake.
29. Gowda D.V et al. Preparation and evaluation of simvastatin transdermal film. International Journal of applied Pharmaceutics. 2018; 10(5): 235-238.
30. Venkata. R.Y et al. A novel vesicular transdermal delivery of nifedipine- preparation, characterization, and in-vitro/in-vivo evaluation. Drug Delivery. 2014.
31. Patel K.K. et al. Formulation of niosomal gel for enhanced transdermal lopinavir delivery and its comparative evaluation with ethosomal gel. National Library of Medicine. 2012; 13(4): 1502-1510.
32. Jadon P.S.et al. Enhanced oral bioavailability of griseofulvin via niosomes, American Association of Pharmaceutical Scientist. 2009; 10(4): 1186-1192.
33. Jaiswal P.H. et al. Formulation of Niosomal gel of Diclofenac sodium and its in-vitro characterization. International Journal of Pharmacy and Pharmaceutical Research. 2016;6(4): 585-600.
34. Dahiya N.K. et al. Preparation and evaluation of ramipril niosome prepared by using sonication method. Acta Pharmaceutica Sciencia, 2011; 53(3): 441-446.
35. Malhotra M. and Jain N.K. Niosomes as Drug Carriers. Indian Drugs. 1994;31 (3): 81-86.
36. Gregoriadis G. Targeting of drugs: implications in medicine. Lancet. 1981; 2(8240): 241-246.
37. Weissman G., Bloomgarden D., Kaplan R., Cohen C., Hoffstein S., Collins T., Gotlieb A. and Nagle D. A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells. Proceedings of the. National. Academy of Science. 1975; 72(1): 88-92.
38. Cummings J., Staurt J.F. and Calman K.C. Determination of adriamycin, adriamycinol, and their 7-deoxyaglycones in human serum by high-performance liquid chromatography. J. Chromatogr. 1984; 311: 125-133.
39. Suzuki K. and Sokan K. The Application of Liposomes to Cosmetics. Cosmetic and Toiletries. Journal of advanced Pharmaceutical Technology and Research. 1990; 105: 65-78.
40. Pandya K.D et al., Niosome: An unique drug delivery system. An International Journal of Pharmaceutical Sciences. 2016; 7(3): 85-99.
41. Carafa M., Santucci E., Lucania G. Lidocaine-loaded non-ionic surfactant vesicles characterization and in vitro permeation studies. International Journal of Pharmaceuticals. 2002; 231: 21–32.
42. Carafa M, Alhaique F, Marianecci C. Niosomes, Freeze-Dried Powder there of and their use in treatment. United states patent application publication, 2012, US 2012/0288540 A1.
43. Gabriele B et al. Novel support system for the transport of active substances into the skin, European Patent Office, 2015, EP2552413B1.
44. Silvana C. Hamann Hans-Jirgen, Hirner I, Kurka P. Ketoprofen liposomes, United State Patents, 1998, US5741515A.
45. Thierry J et al. Composition based on lipid lamellar vesicles incorporating at least a DHEA compound, WIPO (PCT), 2003, WO2003011245A1.
46. Hans E.J et al. Liposomal l-carnitine, United State Patent Application Publication, 2009, US20090196914A1
47. Marie R. Ribier A. The process to facilitate the formation of Niosomes dispersed in an aqueous phase and to improve their stability and their encapsulation rate and corresponding aspersions. 1992, CA1304996C
48. Alcantar N., Dearborn K., Vanauker M., Toomey R., Hood E. Niosome Hydrogel Drug Delivery. 2009, EP2012755A2.
49. Tamizharasi S., Dubey A., Rathi V., Rathi J. C. Development and characterization of niosomal drug delivery of gliclazide. Journal of Young Pharmacy. 2009; 1: 205-209.
50. Khaksa G., D'Souza R., Lewis S., Udupa N. Pharmacokinetic study of niosome encapsulated insulin. Indian Journal of Experimental Biology. 2000; 38: 901- 905.