Author(s): VA Kurkin, AS Tsibina

Email(s): Kurkinvladimir@yandex.ru

DOI: 10.52711/0974-360X.2021.00680   

Address: VA Kurkin*, AS Tsibina
Department of Pharmacognosy, Botany and Phytotherapy, Samara State Medical University, Ulitsa Chapaevskaya 89, Samara, 443099, Russian Federation.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
In the present paper are discussed the results of the study on the development of the new approaches to the standardization of the Monarda fistulosa L. herbs. From the herb of the Monarda fistulosa L. there were isolated for the first time isorhoifolin (apigenin-7-O-rutinoside) and linarin (acacetin-7-O-rutinoside) chemical structures of which there were elucidated by means of 1H-NMR-, 13C-NMR-, UV-spectroscopy, mass spectrometry and results of chemical transformations. It was determined, that the isolated flavonoids cause the spectral characteristics in the UV spectra of the water-ethanolic extracts from the Monarda fistulosa L. herbs. It was substantiated the expediency of the estimation of the total flavonoids in the herbs of Monarda fistulosa L. calculated on isorhoifolin. As results there was development the method of the quantitative determination of the total flavonoids in the herbs of Monarda fistulosa L. by the using of the differential spectrophotometry at an analytical wavelength of 394 nm. It was determined that the content of the total of flavonoids in the raw materials of the studied plant varies from 4.23±0.08% to 7.68±0.12%.


Cite this article:
VA Kurkin, AS Tsibina. The Development of the New Approaches to the Standardization of the Monarda fistulosa L. Herbs. Research Journal of Pharmacy and Technology. 2021; 14(7):3916-0. doi: 10.52711/0974-360X.2021.00680

Cite(Electronic):
VA Kurkin, AS Tsibina. The Development of the New Approaches to the Standardization of the Monarda fistulosa L. Herbs. Research Journal of Pharmacy and Technology. 2021; 14(7):3916-0. doi: 10.52711/0974-360X.2021.00680   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-77


REFERENCES:
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2.    Wild bergamot (Monarda fistulosa L.). United States Department of Agriculture Natural Resourced Conswevation Service. URL: https://plants.usda.gov/plantguide/pdf/cs_mofi.pdf – 17.08.2020.
3.    Naumenko EN, Zhilyakova ET, Novikov OO et al. Research of anti-inflammatory activity of medicine "Monavitol" in vivo. Scientific statements of Belgorod State University. Series: Medicine. Pharmacy. 2012; 22-1(141): 195-198.
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5.    Krasyuk EV, Makarova NN, Petrova IV, Pupykina KA, Valeeva LA. Pharmacological activity of monarda types, introduced in the Republic of Bashkortostan. Medical Bulletin of Bashkortostan. 2015; 10(5): 67-70.
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