Author(s): Sasikala M, Swarnakumari S, Mohan S

Email(s): sasikalampharm@gmail.com

DOI: 10.52711/0974-360X.2021.00670   

Address: Sasikala M1,2*, Swarnakumari S1, Mohan S1
1Karpagam College of Pharmacy, Coimbatore – 641032, Tamil Nadu, India.
2Faculty of Pharmacy, Karpagam Academy of Higher Education, Coimbatore – 641021, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Introduction: Beyond the preceding twenty years progresses in investigative systems and an upsurge in effect usage routes have remarkably enhanced breast cancer endurance proportions, regardless of a cumulative number of identified cases amongst women. Certain plant extracts have been acquired to produce anti-cancer powers and to fit into chemotherapy treatments. Aim and Objective: To accomplish the anticancer activities of phytoconstituents of Ipomoea aquatica Forsskal beside DMBA induced breast cancer in Sprague dawley rats with the addition of assessment of histopathological and biochemical parameters. Methods: There were six groups of animals such G1 (Normal), G2 (tumor), G3 (standard Vinblastine), G4 (hydroalcoholic extract), G5 (Isolated compound I) and G6 (Isolated compound II) correspondingly. Results and discussion: The body weight, defense percentage and tumor volume were determined. A substantial behaviors were detected in G3 (37.85%), G4 (24%), G5 31.70% and G6 (32.65%) after 45 days therapy. The special effects of antioxidant enzymes similar to SOD, CAT, GPX and LPx were examined and had revealed statistically significant findings. Conclusion: Bearing in mind regarding the prolonged medication of patients, natural resolves (plant of interest with its isolated compounds) will control superior deprived of any side effects to cure the ailment in effectual approach.


Cite this article:
Sasikala M, Swarnakumari S, Mohan S. Defensive Consequences of Hydroalcoholic Extract and Isolated Compounds of Ipomoea aquatica Forsskal against DMBA Method. Research Journal of Pharmacy and Technology. 2021; 14(7):3863-8. doi: 10.52711/0974-360X.2021.00670

Cite(Electronic):
Sasikala M, Swarnakumari S, Mohan S. Defensive Consequences of Hydroalcoholic Extract and Isolated Compounds of Ipomoea aquatica Forsskal against DMBA Method. Research Journal of Pharmacy and Technology. 2021; 14(7):3863-8. doi: 10.52711/0974-360X.2021.00670   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-67


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