Author(s): Vivek B. Panchabhai, Santosh R. Butle, Parag G. Ingole


DOI: 10.52711/0974-360X.2021.00667   

Address: Vivek B. Panchabhai*, Santosh R. Butle, Parag G. Ingole
Department of Pharmaceutical Chemistry, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded-431606, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021

We report a novel scaffold of N-substituted 2-phenylpyrido(2,3-d)pyrimidine derivatives with potent antibacterial activity by targeting this biotin carboxylase enzyme. The series of eighteen N-substituted 2-phenylpyrido(2,3-d)pyrimidine derivatives were synthesized, characterized and further molecular docking studied to determine the mode of binding and energy changes with the crystal structure of biotin carboxylase (PDB ID: 2V58) was employed as the receptor with compounds 6a-r as ligands. The results obtained from the simulation were obtained in the form of dock score; these values represent the minimum energies. Compounds 6d, 6l, 6n, 6o, 6r and 6i showed formation of hydrogen bonds with the active site residues and van Der Walls interactions with the biotin carboxylase enzyme in their molecular docking studies. This compound can be studied further and developed into a potential antibacterial lead molecule.

Cite this article:
Vivek B. Panchabhai, Santosh R. Butle, Parag G. Ingole. Synthesis, characterization and molecular docking studies on some new N-substituted 2-phenylpyrido[2,3-d]pyrimidine derivatives. Research Journal of Pharmacy and Technology. 2021; 14(7):3846-4. doi: 10.52711/0974-360X.2021.00667

Vivek B. Panchabhai, Santosh R. Butle, Parag G. Ingole. Synthesis, characterization and molecular docking studies on some new N-substituted 2-phenylpyrido[2,3-d]pyrimidine derivatives. Research Journal of Pharmacy and Technology. 2021; 14(7):3846-4. doi: 10.52711/0974-360X.2021.00667   Available on:

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