Author(s): Krishnat D. Dhekale, Ravindra N. Kamble

Email(s): kravi_73@rediffmail.com

DOI: 10.52711/0974-360X.2021.00666   

Address: Krishnat D. Dhekale, Ravindra N. Kamble*
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune 411038, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
A dry-powder inhaler (DPI) carries medication to lungs as a dry powder, useful against respiratory diseases. The current research was endeavoured to examine the capabilities of Multi-walled carbon nanotubes (MWCNT) as a pulmonary transporter for directing cefdinir to cystic fibrosis (CF). Functionalized MWCNTs were loaded with cefdinir to formulate DPI (F-CEF FMWCNTs DPI) having efficient treatment against lung infections and were evaluated successfully. The outcomes demonstrated that cefdinir loaded FMWCNTs were non-toxic and accomplished 79.73 % entrapment with better flow properties. The optimized formulation had Mass Median Aerodynamic Diameter (MMAD), Fine particle fraction (FPF), and particle size of 3.45±0.09 µm, 58.52±1.06%, 5.25 ± 0.03 µm (CEF FMWCNT DPI) and 4. 29±0.16µm 38.74±1.02%, 7.54 ± 0.02 µm (C-DPI) respectively. The loaded nanotubes showed 72. 63 % release after 15 hours in a controlled manner. The outcome of work recognized a unique, simple, and stable product having improved drug loading and increased dispersibility of carbon nanotubes (CNTs) thus improved bioavailability at a lung infection place with less adverse actions.


Cite this article:
Krishnat D. Dhekale, Ravindra N. Kamble. Development of cefdinir loaded Functionalized carbon Nanotubes dry powder Inhaler for the Treatment of cystic Fibrosis. Research Journal of Pharmacy and Technology. 2021; 14(7):3839-5. doi: 10.52711/0974-360X.2021.00666

Cite(Electronic):
Krishnat D. Dhekale, Ravindra N. Kamble. Development of cefdinir loaded Functionalized carbon Nanotubes dry powder Inhaler for the Treatment of cystic Fibrosis. Research Journal of Pharmacy and Technology. 2021; 14(7):3839-5. doi: 10.52711/0974-360X.2021.00666   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-63


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