Ande Hemanth Kumar, Preethi Sudheer, Ashwini M.
Ande Hemanth Kumar, Preethi Sudheer*, Ashwini M.
Dept. of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelram Post, Bangalore, 560035, Karnataka, India.
Volume - 14,
Issue - 7,
Year - 2021
Stavudine is synthetic analog of reverse transcriptase inhibitor possessing a short half-life of 0.8 to 1.5 hours. Therefore frequent administration of the medication is required which results in poor patient acceptability The following research work aims to prepare the floating microparticles of stavudine with an intention to increase the gastric retention time. Microparticles were prepared via emulsion solvent diffusion method utilizing Eudragit S 100 and Eudragit L 100 as the rate controlling polymers. The influence of these polymers and its compositions on various formulation parameters in addition to the in vitro release characteristics of the microspheres was investigated. The particle size of the prepared microparticles were found to be in the range of 108.25µm to 152.41µm. Free flowing particles which are spherical free flowing with a buoyancy =12 hour in the simulated gastric fluid were obtained. The drug content of the selected micro particles (F12) showed an encapsulation efficiency of up to 85.28±0.18%. In vitro release profiles of floating microspheres indicated a sustained drug release up to 14 hours. Thus, the present formulations could be a superior alternative to conventional oral therapy due to the sustained drug action.
Cite this article:
Ande Hemanth Kumar, Preethi Sudheer, Ashwini M. Floating micro particles of Stavudine: An Exceptional approach for Gastric retention and Sustainable drug action. Research Journal of Pharmacy and Technology. 2021; 14(7):3816-0. doi: 10.52711/0974-360X.2021.00661
Ande Hemanth Kumar, Preethi Sudheer, Ashwini M. Floating micro particles of Stavudine: An Exceptional approach for Gastric retention and Sustainable drug action. Research Journal of Pharmacy and Technology. 2021; 14(7):3816-0. doi: 10.52711/0974-360X.2021.00661 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-58
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