Author(s): Buddhadeb Ghosh, Ravi Kant Sharma, Suman Yadav, Ankita Randev

Email(s): debanatomy@gmail.com

DOI: 10.52711/0974-360X.2021.00660   

Address: Buddhadeb Ghosh1*, Ravi Kant Sharma1, Suman Yadav2, Ankita Randev1
1Department of Anatomy, Government Medical College, Amritsar, Punjab, India.
2Department of Anatomy, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Both aluminium and ethanol are pro-oxidants and toxic. Uncontrolled use of aluminium and increasing trends of ethanol consumption in India increased the chance of coexposure to aluminium and ethanol. There are possibilities, that both of them follow common mechanisms to produce reproductive toxicity. The present study was planned to identify the effects of aluminium administration on the microscopic structure of ovary and to clarify any possible protection conferred by the concomitant administration of ethanol. Sixteen female rats divided into one control and three experimental groups exposed to aluminium (4.2mg/kg body weight) and ethanol (1gm/kg body weight) for 3 months. After the exposure period, ovaries were processed for light microscopic examination. Ovary showed significant atretic follicles with degenerated ova and vacuolation. Rupture of zona pellucida in oocyte seen in aluminium treated animals. Ethanol treated group showing absence of growing follicles, increased large corpora lutea. Dilated and congested vessels were observed in the growing follicle. The effects of combined administration of aluminium and ethanol treated groups showed with acute degeneration of growing follicles, with desquamation of pyknotic granulosa cells and degenerated oocyte. Multiple vacuoles of degenerated granulosa cells with dilated congested vessels and edema seen. Hyaline material seen inside the degenerating follicles. It has been suggested that the ethanol induced augmentation of impacts of aluminium on the Ovary.


Cite this article:
Buddhadeb Ghosh, Ravi Kant Sharma, Suman Yadav, Ankita Randev. Toxic Effects of Aluminium on Female Reproductive System in Presence of Ethanol Coexposure. Research Journal of Pharmacy and Technology. 2021; 14(7):3809-5. doi: 10.52711/0974-360X.2021.00660

Cite(Electronic):
Buddhadeb Ghosh, Ravi Kant Sharma, Suman Yadav, Ankita Randev. Toxic Effects of Aluminium on Female Reproductive System in Presence of Ethanol Coexposure. Research Journal of Pharmacy and Technology. 2021; 14(7):3809-5. doi: 10.52711/0974-360X.2021.00660   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-57


REFERENCE:
1.    Dominigo JL. Reproductive and developmental toxicity of aluminium: a review. Neurotoxicol Teratol.1995; 17:515-521.
2.    Nayak P, Sharma SB. Augmentation of Aluminum-Induced Oxidative Stress in Rat Cerebrum by Presence of Pro-oxidant (Graded Doses of Ethanol) Exposure. Neurochem Res.2010; 35:1681–1690.
3.    Willey. Aluminium. MAK Value Documentation.2012; 1991.
4.    WHO. Aluminium. World Health Organization, International Programme on Chemical Safety.1997; 2.
5.    Lione A. The Prophylactic Reduction of Aluminum intake. Food Chem Toxicol.1983;103-109.
6.    Rebai O, Djebli NE. Chronic Exposure to Aluminum Chloride in Mice: Exploratory Behaviors and Spatial Learning. Advances in Biological Research.2008; 2 (1-2)26-33.
7.    Greger J. Dietary and other sources of aluminum intake. Aluminum in Biology and Medicine. 1992;169, 26-49.
8.    Berihu Ba. Histological and Functional Effect of Aluminium on Male Reproductive System. International Journal of Pharma Sciences and Research.2015; 6:8.
9.    Karimpour A. Developmental Toxicity of Aluminium from High Doses of AlCl3 in Mice. The Journal of Applied Research.2005; 5: 4.
10.    Anane R, Bonini M. Transplacental passage of aluminium from pregnant mice to fetus organs after maternal transcutaneous exposure. Hum ExpToxicol.1997; 16(9):501-4.
11.    Agrawal SK. Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium. Food Chem. Toxicol 1996; 34:49-53.
12.    Fraser RB. Alcohol Consumption and the Outcomes of Pregnancy. RCOG Statement.2006; 5:1-10.
13.    Elizabeth R, Silva DO, Foster D, Harper MM, Seidman CE. Alcohol Consumption Raises HDL Cholesterol Levels by Increasing the Transport Rate of Apolipoproteins A-I and A-II. Circulation. 2000; 102:2347-2352.
14.    Regan TJ. Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women with Type 2 Diabetes Mellitus. Circulation.2000; 102:487-488.
15.    Koppes LJ. Moderate Alcohol Consumption Lowers the Risk of Type 2 Diabetes. Diabetes Care.2005; 28:719–725.
16.    Kuzmin A, Chefer V. Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment. Transl Psychiatry. 2013; 3:72.
17.    Nayak P, Das SK, Vasudevan DM. Role of Ethanol on Aluminum Induced Biochemical Changes on Rat BRAIN. Indian Journal of Clinical Biochemistry.2006; 21 (2) 53-57.
18.    Nayak P, Sharma SB, Chowdary NV. Aluminum and ethanol induce Alterations in superoxide and peroxide handling capacity (SPHC) in frontal and temporal cortex. Indian J Biochem Biophys.2013; 50(5):402-10.
19.    Flora S. Effects of combined exposure to aluminium and ethanol on aluminium body burden and some neuronal, hepatic and haematopoietic biochemical variables in the rat. Hum. Exp. Toxicol.1991; 10: 45-48.
20.    Pena A, Meseguer I. Influence of moderate beer consumption on aluminiumtoxico-kynetics: acute study. Nutr Hosp.2007; 22(3):371-6.
21.    Gonzalez Munoz MJ. Role of beer as a possible protective factor in preventing Alzheimer's disease. Food Chem Toxicol.2008; 46(1):49-56.
22.    Rajeswari TR, Sailaja N. Impact of heavy metals on environmental pollution. J Chem Parmacol Sci.2014; 3:175–181.
23.    Kucharczak E, Moryl A. Contents of metals in cultivated plants in Zgorzelec-Bogatynia region. Part 1. Lead, cadmium, aluminium. Environ.2010;42:52–61.
24.    Kataev GD, Suomela J, Palokangas P. Densities of microtine rodents along a pollution gradient from a copper-nickel smelter. Oecol. 1994;97(4):491–498.
25.    Sheffield SR, Sawicka-Kapusta K, Cohen JB, Rattner BA. Rodentia and lagomorpha. In: Shore RF, Rattner BA (eds) Ecotoxicology of wild mammals. John Wiley and Sons, Ltd, New York.2001.
26.    Cornulier T, Yoccoz NG, Bretagnolle V, Brommer JE, Butet A, Ecke F, Elston DA, Framstad E, Henttonen H, Hörnfeldt B, Huitu O, Imholt C, Ims RA, Jacob J, Jędrzejewska B,Millon A, Petty SJ, Pietiäinen H, Tkadlec E, Zub K, Lambin X. Europe-wide dampening of population cycles in keystone herbivores. Science. 2013; 340(6128):63–66.
27.    Bishop NJ, Morley R, Day JP, Lucas A. Aluminum neurotoxicity in preterm infants receiving intravenousfeeding solutions. N Engl J Med.1997; 336(22):1557–1561.
28.    Walton JR. A longitudinal study of rats chronically exposed to aluminum at human dietary levels. Neurosci Lett. 2007; 412(1):29–33.
29.    Yokel RA, Rhineheimer SS, Sharma P, Elmore D, Mcnamara PJ. Entry, half-life, and desferrioxamine-accelerated clearance of brain aluminum after a single Al exposure. Toxicol Sci.2001; 64(1):77–82.
30.    Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, Kacew S, Lindsay J, Mahfouz AM, Rondeau V. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev.2007; 10(1):1–269.
31.    Mohammed A, Mayyas I, Elbetieha A, Shoter A, Khamas W, Elnasser Z. Toxicity evaluation of aluminium chloride on adult female mice. J Anim Vet Adv.2008; 7:552–556.
32.    Fu Y, Jia FB, Wang J, Song M, Liu SM, Li YF, Liu SZ, Qw B. (2014) Effects of sub-chronic aluminum chloride exposure on rat ovaries. Life Sci. 2014;100(1):61–66.
33.    Trif A, Muselin F, Rargherie D, Dumitrescu E, Macinic I. The consequences of chronic exposure to aluminium on some morphological biomarkers of reproductive function (body, genital organs, sexual accessory glands weight, seminiferous tubules diameter) in male rats. Luc Stin Med Vet. 2007; 10:652–658.
34.    Contini Mdel C, Millen N, Gonzalez M, Mahieu S. Melatonin prevents oxidative stress in ovariectomized rats treated with aluminium. Biol Trace Elem Res. 2011; 144(1–3):924–943.
35.    Muselin F, Trif A, Dumitrescu E, Cimpoes GS. Body weight dynamics in rats exposed to aluminium, melatonin and Sempervivum extract. Luc Stiin - Uni Stiin Agri Banat Tim Med Vet.2011; 44(2):129–132.
36.    Abu-Taweel GM, Ajarem JS, Ebaid H. Aluminum-induced testosterone decrease results in physiological and behavioral changes in male mice. Afr J Biotechnol. 2011; 10(2):201–208.
37.    Kime DE. The effects of pollution on reproduction in fish. Reviews in Fish Biology and Fisherie.1995; 5(1) 52-96.
38.    Damek Poprawa M, Sawicka-Kapusta K. Damage to the liver, kidney, and testis with reference to burden of heavy metals in yellow-necked mice from areas around steelworks and zinc smelters in poland. Toxicology.2003; 186(1-2)1-10.
39.    Zhang YM, Huang DJ, Wang YQ, Liu JH, Yu RL, Long J. Heavy metal accumulation and tissue damage in goldfish carassius auratus. Bulletin of Environmental Contamination and Toxicology.2005; 75(6):1191-1199.
40.    Martin-Diaz ML, Tuberty SR, Mckenney Ll, Blasco J, Sarasquete C, Delvalls TA. The use of bioaccumulation, biomarkers and histopathology diseases in procambarus clarkii to establish bioavailability of cd and zn after a mining spill. Environmental Monitoring and Assessment.2006; 116(1-3):169-184.
41.    Raldua D, Diez S, Bayona JM, Barcelo D. Mercury levels and liver pathology in feral fish living in the vicinity of a mercury cell chlor-alkali factory. Chemosphere. 2007; 66(7): 1217-1225.
42.    Aschkenasy Lelu P. des boissons alcoolises sur le rencdenment reproducteur dii rat. C. R. Acad. Sci. Agric. Bulg. 1958; 246: 1275-1277.
43.    Craniston EM. Effect of traniquilizers and other agenits oni sexuial cycle of imicie. Proc. Soc. Exp. Biol. Mled. 1958; 98: 320-322.
44.    Aroni E, Flanzy M, Combescot C, Ptuisais J, Demnaret J, Revnouiard-Brault F, Igert AC. L'alcool estildanis le vin 1'element (Iqui perturbe, chez la ratte, le eycle vaginal? Btull. Acad. Natl. Med. (Paris). 1965; 149: 112-120.
45.    Van Thiel DH, Lester R. Alcoholism: its effect on hypothalamic-pituitary-goniadal functioni. Gastroenterology.1976; 71: 318-327.
46.    Gordon GG, Altman K, Southren AL, Rubini E, Lieber CS. Effect of alcohol (ethanol) administration on sex-hormone metabolismii in normal men. N. Engl. J. Med.1976; 295: 793-797.
47.    Sherlock S. Diseases of the Liver aind Biliarv System. Blackwell Scientific Publications Ltd., Oxford. 5th edition. 1975; 64-83.
48.    Conn HO. Cirrhosis. In Diseases of the Liver. L. Schiff, editor. J. B. Lippincott Co., Philadelphia. 4th edition. 1975; 833-939.
49.    Lieber CS, Feinman L, Rubin E. Alcohol and the liver. In Gastroenterology. H. L. Bockus, editor. W. B. Saunders Company, Philadelphia. 3rd edition. 1976; 342-365.
50.    Van Thiel DH, Lester R, Sherinis RJ. Hypogonadism in alcoholic liver disease: evidence for a double defect. Gastroenterology.1974; 67: 1188-1199.
51.    Van Thiel DH, Gavaler JS, Vaitukaitis J, Lester R. (1976) Evidence for an isolated defect in pituitary secretioni of LH in chronic alcoholic meni. Gastroenterology1976; 71: A40/933.
52.    Paisseau G, Ounanasky V. Syndrome hvpophysaire avec cirrhose dii doie et splenom,6galie. Buill. Mem. Soc. Med. Paris.1930; 54: 267-273.
53.    Laignel L, Troiser J, Boquien Y. Association de la cirrhose de foie a tine depilation plus oi moims complete et a une insufficaniee thyroovarenne. Bull. MWin. Soc. Mled. Paris.1931; 47: 829-837.
54.    Rollerston H. Diseases ofthe Liver. Oxford Medical Press, Oxford.1933; 3: 303-333.
55.    Ratnioff OD, Andcl AJ, Patek JR. The natural history of Laenniiec's cirrhosis of the liver: analysis of :386 cases. Medicine (Baltimiiore). 1942;21: 207-268.
56.    Snmith DW, Jones KL, Hanson JW. Perspectives on the cause and frequency of the fetal alcohol synidrome. Ann. N.Y. Acad. Sci. 1976; 273: 138-139.
57.    Green HG. Infants of alcoholic mothers. Am. J. Obstet. Gyniecol. 1974; 118: 713-716.
58.    Miulvihill JJ, Klimas JT, Stokes DC, Risemberg HN. Fetal alcohol syndrome: seveni new cases. Am. J. Obstet. Gynecol.1976; 125: 937-941.
59.    Randall CL, Taylor WL, Walker DXV. Ethanol-induced malformation inl mice. Alcohol. Clitn. Exp. Res.1977; 1: 219-224.
60.    Russell M. Intrauterine growth in infants born to womeni with alcohol-related psychiatric diagnoses. Alcohol. Clin. Exp. Res.1997; 1: 225-231.
61.    Jones KL, Smith DW, Ulleland CN, Pytkowicz Streissgtuth A. Patterni of malformation in offsprinig ofchronic alcoholic mothers. Latncet. I. 1973; 1267-1271.
62.    Deane HW, Lobel BL, Romney SL. Enzymatic histochemistry of normal human ovaries of the menstrual cycle, pregnancy, and the early puerperium. Am. J. Obstet. GyJnecol.1962; 83: 281-294.
63.    Richardson GS. Hormonal physiology of the ovary. In Gynecologic Endocrinology. J. J. Bold, editor. Harper and Row, Publishers, Inc., New York. 2nd edition. 1975; 55-77.
64.    Thiel D, Gavaler J, Lester R, Sherins R. Alcohol Induced Ovarian Failure in the Rat. Journal of Clinical Investigation.1978; 61(3) 624-632.
65.    Bo W, Krueger W, Rudeen P, Symmes S. Ethanol-Induced Alterations in the Morphology and Function of the Rat Ovary. The Anatomical Record.1982; 202. 255- 260.
66.    Oakberg E. Follicular Growth and Atresia in the Mouse. In Vitro. 1979;15 (1) 41- 49.
67.    Spanel BK. Morphological Dynamics and Potential Role of Innate Immunity. Atlas of the Mammalian Ovary.2012; 9-10.
68.    Gill J. The Effects of Moderate Alcohol Consumption on Female Hormone Levels and Reproductive Function. Alcohol Alcohol.2000; 35 (5) 417-423
69.    Ghorbel I, Amara IB, Ktari N, Elwej A, Boudawara O, Boudawara T, Zeghal N. Aluminium and Acrylamide Disrupt Cerebellum Redox States, Cholinergic Function and Membrane Bound ATPase in Adult Rats and Their Offspring. Biol Trace Elem Res. 2016; 174:335–346.
70.    Chinoy NJ, Bhattacharya S. Effects of chronic administration of aluminium chloride on reproductive functions of testis and some accessory sex organs of male mice. Indian J Environ Toxicol.1997; 7:12-5.
71.    Chinoy NJ, Patel D. Influence of fluoride on biological free radicals in ovary of mice and its reversal. Environ Sci.1998; 6:171-84.
72.    Chinoy NJ, Walimbe AS, Vyas HA, Mangla P. Transient and reversible fluoride toxicity in some soft tissues of female mice. Fluoride.1994; 27:205-14.

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