Hindustan Abdul Ahad, Chinthaginjala Haranath, Naga Jyothi Varam, Tarun Ksheerasagare, Jyothi Vinay Krishna, Siddartha Tharun Teja
Hindustan Abdul Ahad*, Chinthaginjala Haranath, Naga Jyothi Varam, Tarun Ksheerasagare, Jyothi Vinay Krishna, Siddartha Tharun Teja
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu – 515721, Andhra Pradesh, India.
Volume - 14,
Issue - 7,
Year - 2021
The main aim of the present investigation was to explore the Liver shielding of Ficus benghalensis fruit extracts alongside perchloromethane persuaded toxic hepatitis in New Zealand albino rats. The ethanolic extract of the fruits of F. benghalensis (Family: Moraceae) was evaluated for Liver shielding in New Zealand Albino rats with liver mutilation persuaded by perchloromethane. F. benghalensis fruit extract unveiled a momentous Liver shielding consequence by dropping the serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total serum bilirubin (TSB) and malondialdehyde equivalent 500 mg/kg (oral). These biochemical explanations were accompanied by a histopathological assessment of liver segments. The liver shielding of F. benghalensis fruit extracts was comparable to that of a known Liver shielding Liv-52.
Cite this article:
Hindustan Abdul Ahad, Chinthaginjala Haranath, Naga Jyothi Varam, Tarun Ksheerasagare, Jyothi Vinay Krishna, Siddartha Tharun Teja. Liver Shielding Activity of Ficus benghalensis Fruit Extracts Contrary to Perchloromethane prompted Toxic Hepatitis in New Zealand Albino Rats. Research Journal of Pharmacy and Technology. 2021; 14(7):3739-3. doi: 10.52711/0974-360X.2021.00647
Hindustan Abdul Ahad, Chinthaginjala Haranath, Naga Jyothi Varam, Tarun Ksheerasagare, Jyothi Vinay Krishna, Siddartha Tharun Teja. Liver Shielding Activity of Ficus benghalensis Fruit Extracts Contrary to Perchloromethane prompted Toxic Hepatitis in New Zealand Albino Rats. Research Journal of Pharmacy and Technology. 2021; 14(7):3739-3. doi: 10.52711/0974-360X.2021.00647 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-44
1. Kalra A, Tuma F. Anatomy, Abdomen and Pelvis, Peritoneum. In Stat Pearls [Internet] 2018 Nov 26. Stat Pearls Publishing.
2. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology. 2014 Jan 10; 4: 177.
3. Patel R, Gautam P. Medicinal potency of Ficus bengalensis. Medicinal Chemistry and Analysis. 2014; 4(1): 53-58.
4. Patel MA, Patel PK, Patel MB. Effects of ethanol extract of Ficus bengalensis (bark) on inflammatory bowel disease. Indian Journal of Pharmacology. 2010 Aug; 42(4): 214.
5. Deepa P, Sowndhararajan K, Kim S, Park SJ. A role of Ficus species in the management of diabetes mellitus: A review. Journal of Ethnopharmacology. 2018 Apr 6; 215: 210-32.
6. Umair M, Altaf M, Abbasi AM. An ethnobotanical survey of indigenous medicinal plants in Hafizabad district, Punjab-Pakistan. PloS one. 2017 Jun 2; 12(6): e0177912.
7. Rajdev K, Jain S, Mahendra CH, Bhattacharaya SK. Antinociceptive Effect of Ficus bengalensis Bark Extract in Experimental Models of Pain. Cureus. 2018 Mar; 10(3).
8. Bhanwase AS, Alagawadi KR. Antioxidant and Immunomodulatory activity of Hydroalcoholic extract and its fractions of leaves of Ficus benghalensis Linn. Pharmacognosy Research. 2016 Jan; 8(1): 50.
9. Kunwar RM, Bussmann RW. Ficus (Fig) species in Nepal: a review of diversity and indigenous uses. Lyonia. 2006 Jun; 11(1): 85-97.
10. Muthu C, Ayyanar M, Raja N, Ignacimuthu S. Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India. Journal of Ethnobiology and Ethnomedicine. 2006 Dec; 2(1): 43.
11. Chandrasekar SB, Bhanumathy M, Pawar AT, Somasundaram T. Phytopharmacology of Ficus religiosa. Pharmacognosy Reviews. 2010 Jul; 4(8): 195.
12. Singh D, Singh B, Goel RK. Traditional uses, phytochemistry and pharmacology of Ficus religiosa: A review. Journal of Ethnopharmacology. 2011 Apr 12; 134(3): 565-83.
13. Eshwarappa RS, Iyer S, Subaramaihha SR, Richard SA, Dhananjaya BL. Antioxidant activities of Ficus glomerata (moraceae) leaf gall extracts. Pharmacognosy Research. 2015 Jan; 7(1): 114.
14. Daniel RS, Devi KS, Augusti KT, Nair CR. Mechanism of action of antiatherogenic and related effects of Ficus bengalensis Linn. Flavonoids in Experimental Animals.
15. Gulecha V, Sivakuma T. Anticancer activity of Tephrosia purpurea and Ficus religiosa using MCF 7 cell lines. Asian Pacific Journal of Tropical Medicine. 2011 Jul 1; 4(7): 526-9.
16. Ali B, Mujeeb M, Aeri V, Mir SR, Faiyazuddin M, Shakeel F. Anti-inflammatory and antioxidant activity of Ficus carica Linn. Leaves. Natural Product Research. 2012 Mar 1; 26(5): 460-5.
17. Thakare VN, Suralkar AA, Deshpande AD, Naik SR. Stem bark extraction of Ficus bengalensis Linn for anti-inflammatory and analgesic activity in animal models.
18. Panday DR, Rauniar GP. Effect of root-extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle co-ordination and seizure in animal models. BMC Complementary and Alternative Medicine. 2016 Dec; 16(1): 429.
19. Kulshreshtha M, Goswami M, Rao CV, Ashwlayan VD, Yadav S. Anti-Ulcerogenic Potential of Ficus bengalensis Leaf, Biochemical Parameter and Histopathological Study. Journal of Applied Pharmaceutical Science. 2011 Apr 1; 1(2): 65.
20. Yadav YC. Hepatoprotective effect of Ficus religiosa latex on cisplatin induced liver injury in Wistar rats. Revista Brasileira de Farmacognosia. 2015 Jun; 25(3): 278-83.
21. Ahad HA, Kumar CS, Kumar BA, Reddy BA, Shekar AC, Sagar NR. Permeation studies of diclofenac sodium from Ficus carica fruit mucilage matrices for transdermal delivery. International Journal of Chem Tech Research. 2010; 2(2): 937-41.
22. Sabale P, Bhimani B, Prajapati C, Sabale V. An overview of medicinal plants as wound healers. Journal of Applied Pharmaceutical Science. 2012 Nov; 2(11): 143-50.
23. Gayathri M, Kannabiran K. Antidiabetic and ameliorative potential of Ficus bengalensis bark extract in streptozotocin induced diabetic rats. Indian Journal of Clinical Biochemistry. 2008 Oct 1; 23(4): 394-400.
24. Rao RS, Bhadra B, Shivaji S. Isolation and characterization of ethanol‐producing yeasts from fruits and tree barks. Letters in Applied Microbiology. 2008 Jul; 47(1): 19-24.
25. Rahmani AH, Aldebasi YH. Ficus carica and its constituent’s role in management of diseases. Asian J Pharm Clin Res. 2017; 10(6): 49-53.
26. Khan KY, Khan MA, Ahmad M, Hussain I, Mazari P, Fazal H, Ali B, Khan IZ. Hypoglycemic potential of genus Ficus L.: A review of ten years of Plant Based Medicine used to cure Diabetes (2000-2010). Journal of Applied Pharmaceutical Science. 2011; 1(06): 223-7.
27. Wang G, Li Z, Li H, Li L, Li J, Yu C. Metabolic profile changes of CCl4-liver fibrosis and inhibitory effects of Jiaqi Ganxian granule. Molecules. 2016 Jun; 21(6): 698.
28. Tirkey N, Pilkhwal S, Kuhad A, Chopra K. Hesperidin, a citrus bioflavonoid, and decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacology. 2005 Dec 1; 5(1): 2.
29. Ahad HA, Sreeramulu J, Bindu VH, Ramyasree P, Padmaja BS, Sravanthi M. Isolation and physicochemical characterization of Ficus reticulata fruit mucilage. International Journal of Green Pharmacy (IJGP). 2011; 5(2).
30. Kim JW, Kim TB, Kim HW, Park SW, Kim HP, Sung SH. Hepatoprotective flavonoids in Opuntia ficus-indica fruits by reducing oxidative stress in primary rat hepatocytes. Pharmacognosy Magazine. 2017 Jul; 13(51): 472.
31. Ahad HA, Padmaja BS, Sravanthi M, Ramyasree P, Kavitha K. Phytochemical screening and anti-inflammatory actions of Alangium salviifolium root extract. Natural Product Research. 2012 Sep 1; 26(17): 1649-53.
32. Deniz GY, Laloglu E, Koc K, Geyikoglu F. Hepatoprotective potential of Ferula communis extract for carbon tetrachloride induced hepatotoxicity and oxidative damage in rats. Biotechnic and Histochemistry. 2019 Jul 4; 94(5): 334-40.