Author(s): Vimal John Samuel, Rashmi DV, Agasa Ramu Mahesh

Email(s): mahesh-sps@dsu.edu.in , armahesh@hotmail.com

DOI: 10.52711/0974-360X.2021.00645   

Address: Vimal John Samuel, Rashmi DV, Agasa Ramu Mahesh*
College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Plant derived products play a vital role in preventing and treating various disease in humans. Tephrosia tinctoria is a plant belonging to the family Leguminosae, found to have antidiabetic and antioxidant activities. The study was aimed to investigate the anti-diabetic and anti-oxidant activity of whole plant of Tephrosia tinctoria in diabetic rats. Alloxan induced model was used to induce Diabetes. The chloroform and ethanolic extracts of Tephrosia tinctoria (CETT and EETT) at the dose of 250 and 500mg/kg b.w were administered orally at single dose per day to diabetic rats. Glipizide 5mg/kg b.w was used as standard drug. The general body weight, insulin level, blood glucose, serum lipid profile, superoxide dismutase, and lipid peroxidation assays were the parameters evaluated in diabetic rats. EETT have better anti-diabetic and anti-oxidant activity than CETT. The protective effects were even confirmed by histopathological studies. These observations show that both the extracts were effective in possessing the significant antidiabetic and antioxidant properties in alloxan induced diabetes.


Cite this article:
Vimal John Samuel, Rashmi DV, Agasa Ramu Mahesh. Antidiabetic activity of Tephrosia tinctoria in Alloxan induced Diabetic Rats: A Preliminary Study. Research Journal of Pharmacy and Technology. 2021; 14(7):3727-2. doi: 10.52711/0974-360X.2021.00645

Cite(Electronic):
Vimal John Samuel, Rashmi DV, Agasa Ramu Mahesh. Antidiabetic activity of Tephrosia tinctoria in Alloxan induced Diabetic Rats: A Preliminary Study. Research Journal of Pharmacy and Technology. 2021; 14(7):3727-2. doi: 10.52711/0974-360X.2021.00645   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-42


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