ABSTRACT:
Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.
Cite this article:
Pooja, Mazumder Avijit, Saumya Das. Hepatoprotective nature of aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model. Research Journal of Pharmacy and Technology. 2021; 14(7):3716-0. doi: 10.52711/0974-360X.2021.00643
Cite(Electronic):
Pooja, Mazumder Avijit, Saumya Das. Hepatoprotective nature of aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model. Research Journal of Pharmacy and Technology. 2021; 14(7):3716-0. doi: 10.52711/0974-360X.2021.00643 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-40
REFERENCES:
1. "Caesalpinia pulcherrima". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 2010-12-03.
2. Kumar, S., Singh, J., Baghotia, A., Mehta, V., Thakur, V., Choudhary M, Verma S, Kumar D., 2013. Antifertility potential of the ethanolic extract of Caesalpinia pulcherrima leaves. Asian Pacific Journal of Reproduction, Vol. 2 Issue 2, pp 90-92.
3. Pankaj, N., Deepak, N., Ranveer, B., 2011. A review on phytochemical and pharmacological aspects of Caesalpinia pulcherrima. International Journal of Research in Ayurveda and Pharmacy. Vol. 2 issue 2, pp.416-421.
4. Sharma, V., and Rajani, G.P., 2011. Evaluation of Caesalpinia pulcherrima Linn. for anti-inflammatory and antiulcer activities. Indian Journal of Pharmacology. Vol.43 Issue 2, p.168.
5. Pawar, C.R., Gulecha, V.S., Mohan, M., Kasture, V.S., Pal, S.C., 2008. Anti-inflammatory activity of heartwood extracts of Caesalpinia pulcherrima (Caesalpiniceae). Journal of Natural Remedies. Vol. 8 Issue 1, pp. 72-5.
6. Chiang, L.C., Chiang, W., Liu, M.C., Lin, C.C., 2003. In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids. Journal of Antimicrobial Chemotherapy. Vol.52 Issue 2, pp.194-198.
7. Kumar, S., Singh, J., Baghotia, A., Mehta, V., Thakur, V., Choudhary M, Verma S, Kumar D., 2013. Antifertility potential of the ethanolic extract of Caesalpinia pulcherrima leaves. Asian Pacific Journal of Reproduction, Vol. 2 Issue 2, pp 90-92.
8. Prakash, S.B., Sharmistha, P., Kumar, A.R., 2009. Antibacterial Activity of Methanolic Extract of Roots of Caesalpinia Pulcherrima. International Journal of Chemical Sciences. Vol.7 Issue 1, pp.16-18.
9. Chanda, S., Parekh J., Baravalia Y., 2010. Antimicrobial and antioxidant efficacy of various solvent extracts of seeds and fruits rind of Caesalpinia pulcherrima Swartz. Archives of Clinical Microbiology.Vol.1 Issue 4, pp.4-10.
10. Pawar, C.R., Mutha, R.E., Landge, A.D., Jadhav, R.B., Surana, S.J., 2009. Antioxidant and cytotoxic activities of Caesalpinia pulcherrima wood. Indian journal of Biochemistry and Biophysics. Vol. 46, pp.198-200.
11. Rajan, M.S., Vaishnav, R., Sheno, A., Shenoy, A., Shabharaya, A.S., 2012. Huxley VH. Antiulcer Activity of Hyder Y of Hyder Y of hydro-alcoholic extra alcoholic extract of Caesalpinia pulcherrima Linn. Journal of Basic and Applied Biology. Vol.6, pp. 56-62
12. Sharma, V., and Rajani, G.P., 2011. Evaluation of Caesalpinia pulcherrima Linn. for anti-inflammatory and antiulcer activities. Indian Journal of Pharmacology. Vol.43 Issue 2, p.168.
13. Wilkinson PC, 1978. Neutrophil adhesion test. Handbook of Experimental Pharmacology New Delhi 1978, Vol.1, pp. 109.
14. Shivaprasad, H.N., Kharya, M.D., Rana, A.C., Mohan, S., 2006. Preliminary immunomodulatory activities of aqueous extract of Terminalia chebula. Pharmaceutical Biology. Vol.1 Issue 44, pp. 32–34.
15. Dhaked S. Phuspendra, Kshirsagar N. Sunil and Sakarar D.M., 2017. Antimicrobial activity of ethanolic and aqueous extract of Caesalpinia pulcherrima flowers. International Journal of Pharmaceutical Science and Research . Sr no; 22,pp.2643-2646.
16. Chakraborthy GS, Badujar RS, Pardeshi CR. Analgesic activity of chloroform extract of Caesalpinia pulcherrima. J Pharm Res. 2009;2:1199–1200.
17. A.E. Kitabchi and S. Dagogo-sJack. "Pathophysiology Course-Endocrine Module." Physiology of Endocrine Pancreas and Pathophysiology of Diabetes Mellitus (DM) 4, no. (2009): 6-48
18. I.J. Goldberg. "Diabetic Dyslipidemia: Causes and Consequences." The Journal of Clinical Endocrinology and Metabolism 86, no. 3 (2001): 965-971
19. I.-M. Liu, S.-S. Liou, T.-W. Lan, F.-L. Hsu and J.-T. Cheng. "Myricetin as the Active Principle of Abelmoschus Moschatus to Lower Plasma Glucose in Streptozotocin- Induced Diabetic Rats." Planta Medica 71, no. 07 (2005): 617-621
20. J.-M. Schwarz, P. Linfoot, D. Dare and K. Aghajanian. "Hepatic De Novo Lipogenesis in Normoinsulinemic and Hyperinsulinemic Subjects Consuming High-Fat, Low- Carbohydrate and Low-Fat, High-Carbohydrate Isoenergetic Diets." The American Journal of Clinical Nutrition 77, no. 1 (2003): 43-50