Author(s): Arif Nur Muhammad Ansori, Amaq Fadholly, Annise Proboningrat, Suhailah Hayaza, Raden Joko Kuncoroningrat Susilo, Sin War Naw, Gabrielle Ann Villar Posa, Yuhanis Firza Yusrizal, Mada Triandala Sibero, Teguh Hari Sucipto, Soegeng Soegijanto

Email(s): teguhharisucipto@staf.unair.ac.id

DOI: 10.52711/0974-360X.2021.00641   

Address: Arif Nur Muhammad Ansori1, Amaq Fadholly1, Annise Proboningrat1, Suhailah Hayaza2, Raden Joko Kuncoroningrat Susilo2, Sin War Naw3, Gabrielle Ann Villar Posa4, Yuhanis Firza Yusrizal5, Mada Triandala Sibero6, Teguh Hari Sucipto7*, Soegeng Soegijanto7
1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Doctoral Program in Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
3Department of Chemistry, Myitkyina University, Myitkyina, Myanmar.
4School of Environmental Science and Management, University of the Philippines Los Baños, Los Banos, Philippines. 5Management and Science University, Shah Alam, Malaysia.
6Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, Indonesia. 7Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii stem bark and cone were evaluated against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia. We revealed that P. merkusii stem bark and cone inhibited DENV-2 in Vero cells (originally from African green monkey kidney) with IC50= 140.63 µg/mL and 73.78 µg/mL, CC50= 89.65 µg/mL and 249.5 µg/mL, SI= 0.64 and 3.38, respectively. The findings presented here suggest that P. merkusii stem bark and cone exerts potent antiviral activity against DENV-2. Hence, P. merkusii stem bark and cone are potent to inhibit DENV-2 and should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV-2.


Cite this article:
Arif Nur Muhammad Ansori, Amaq Fadholly, Annise Proboningrat, Suhailah Hayaza, Raden Joko Kuncoroningrat Susilo, Sin War Naw, Gabrielle Ann Villar Posa, Yuhanis Firza Yusrizal, Mada Triandala Sibero, Teguh Hari Sucipto, Soegeng Soegijanto. In Vitro Antiviral Activity of Pinus merkusii (Pinaceae) Stem Bark and Cone against Dengue Virus Type-2 (DENV-2). Research Journal of Pharmacy and Technology. 2021; 14(7):3705-8. doi: 10.52711/0974-360X.2021.00641

Cite(Electronic):
Arif Nur Muhammad Ansori, Amaq Fadholly, Annise Proboningrat, Suhailah Hayaza, Raden Joko Kuncoroningrat Susilo, Sin War Naw, Gabrielle Ann Villar Posa, Yuhanis Firza Yusrizal, Mada Triandala Sibero, Teguh Hari Sucipto, Soegeng Soegijanto. In Vitro Antiviral Activity of Pinus merkusii (Pinaceae) Stem Bark and Cone against Dengue Virus Type-2 (DENV-2). Research Journal of Pharmacy and Technology. 2021; 14(7):3705-8. doi: 10.52711/0974-360X.2021.00641   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-38


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