Author(s): S. Venkateswara Rao, S. Sathesh Kumar

Email(s): sathesh2000@gmail.com

DOI: sathesh2000@gmail.com   

Address: S. Venkateswara Rao1, S. Sathesh Kumar2*
1Department of Pharmaceutics, Vel’s Institute of Science, Technology and Advanced Studies (VISTAS), Vel’s University, Chennai–600117, Tamilnadu, India.
2School of Pharmaceutical Sciences, Vel’s Institute of Science, Technology and Advanced Studies (VISTAS), Vel’s University, Chennai–600117, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
The present work was aimed to prepare and evaluate Flutamide loaded methoxy poly (ethylene glycol) poly caprolactone (mPEG–PCL) nanoparticles for targeted delivery to the prostate cancer. The nanoparticles (NPs) were prepared by 23 factorial design and nanoprecipitation method. Various trials were evaluated for surface morphology, particle size and zeta potential. The influences of three formulation excipients such as polymer, stabilizer and organic phase volume on the characterization of NPs were investigated. The results of fourier transform infrared (FTIR) studies were indicated no interaction between the drug and polymer. The particle size varied from 79.2 to 89.1 nm and zeta potential value was found to be - 41.5 mv. The surface morphology of NPs was observed using scanning electron microscopy (SEM) and understands the arrangement and orientation of NPs to determine its behavior and stability. Flutamide loaded mPEG–PCL nanoparticle is a potential new carrier system for treatment of prostate cancer, which may overcome the problems associated with conventional formulations such as tablets.


Cite this article:
S. Venkateswara Rao, S. Sathesh Kumar. mPEG-PCL Nanoparticles as New Carriers for Delivery of a Prostae Cancer Drug Fluamide. Research Journal of Pharmacy and Technology. 2021; 14(7):3657-1. doi: sathesh2000@gmail.com

Cite(Electronic):
S. Venkateswara Rao, S. Sathesh Kumar. mPEG-PCL Nanoparticles as New Carriers for Delivery of a Prostae Cancer Drug Fluamide. Research Journal of Pharmacy and Technology. 2021; 14(7):3657-1. doi: sathesh2000@gmail.com   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-29


REFERENCES:
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2.    Kim J and Bae Y. Albumin loaded microsphere of amphiphilic poly(ethylene glycol)/ poly(α-ester) multiblock copolymer. Eur J of Pharm Sci. 2004; 23: 245–251.
3.    Hossein Danafar. MPEG–PCL copolymeric nanoparticles in drug delivery systems. Cogent Medicine. 2016; 3: 1 – 11
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5.    Danafar H, Rostamizadeh K, Davaran S, Valizadeh H and Hamidi, M. Biodegradable m- PEG/PCL core- Shell Micelles: Preparation and characterization as a sustained release formulation for curcumin. Adv Pharm Bull. 2014; 4: 501–510.
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