Moushira Zaki, Sanaa Kamal, Mona Abd Elmotaleb A. Hussein, Hend M. Tawfeek, Mina Wassef Girgiss, Amr MM Ibrahim, Eman R. Youness
Moushira Zaki1, Sanaa Kamal1, Mona Abd Elmotaleb A. Hussein2, Hend M. Tawfeek3, Mina Wassef Girgiss4, Amr MM Ibrahim5, Eman R. Youness5
1Biological Anthropology Department, National Research Centre, Giza, Egypt.
2Internal Medicine National Institute of Diabetes and Endocrinology, Cairo, Egypt.
3Internal Medicine Faculty of Medicine, Al-Azhar University- Girls.
4Medical Department, Medical Research Division, National Research Centre, Giza, Egypt.
5Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt.
Volume - 14,
Issue - 7,
Year - 2021
Background: Chemerin has been newly defined to be released from mature adipocytes and the chemerin concentrations in human serum augmented with obesity. There is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. The aim of this study is to expound the prospective role of chemerin the in inflammation. Also, investigate relation between chemerin and serum lipid, glucose, body fat percentage, and metabolic parameters in obese and lean women with IR. Lymphocytes and neutrophils play a major role in inflammation and comprise the first line of defense against infection. The ratio of absolute neutrophil count to lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR), determined as is a novel inflammatory biomarker utilized as a prognostic factor in numerous diseases Methods: This study was designed to investigate serum chemerin, NLR, and high-sensitive C-reactive protein (hsCRP) levels in 50 obese women with IR and 50 lean healthy women. Results: Obese group had significant higher levels of serum chemerin, NLR, hsCRP levels and metabolic parameters than lean one. Chemerin also correlated positively with NLR inflammatory marker and body mass index (BMI). Neutrophil-to-lymphocyte ratio was related to pro-inflammatory Conclusion: The present study elucidates that chemerin levels are concomitant with obesity and IR and could play a role in the inflammation, having key aspects of metabolic syndrome.
Cite this article:
Moushira Zaki, Sanaa Kamal, Mona Abd Elmotaleb A. Hussein, Hend M. Tawfeek, Mina Wassef Girgiss, Amr MM Ibrahim, Eman R. Youness. Comparative Study of Chemerin and Inflammatory markers between Obese with Insulin Resistance and lean healthy women. Research Journal of Pharmacy and Technology. 2021; 14(7):3647-0. doi: 10.52711/0974-360X.2021.00630
Moushira Zaki, Sanaa Kamal, Mona Abd Elmotaleb A. Hussein, Hend M. Tawfeek, Mina Wassef Girgiss, Amr MM Ibrahim, Eman R. Youness. Comparative Study of Chemerin and Inflammatory markers between Obese with Insulin Resistance and lean healthy women. Research Journal of Pharmacy and Technology. 2021; 14(7):3647-0. doi: 10.52711/0974-360X.2021.00630 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-27
1. Aldoori, N.M., 2017. Prevalence of obesity among female adolescents in al-hillah city: future risk of cardiovascular diseases. Research Journal of Pharmacy and Technology, 10(7): pp.2127-2131.
2. Aripriya Doraiswamy, H. and Kirshnamurthy, V., Cinnamaldehyde Inhibits Visceral Fat Accumulation and the levels of Glucose, Insulin, Leptin in Serum of rats fed with High Fat Diet (HFD).
3. Ashames, A. et al., 2019. Correlation between Neck Circumference, Waist Circumference, Body Mass Index, and Overweight/Obesity among Ajman University Students. Research Journal of Pharmacy and Technology, 12(5): pp.2443-2452.
4. Bahadır, A. et al., 2015. Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome? Anatolian Journal of Cardiology, 15(10): p.816.
5. Bastard, J.-P. et al., 2006. Recent advances in the relationship between obesity, inflammation, and insulin resistance. European Cytokine Network, 17(1): pp.4-12.
6. Bedelbayeva, G. et al., 2018. Factors of the complicated course of the myocardial infarction in men and women. Research Journal of Pharmacy and Technology, 11(5): pp.1737-1744.
7. Borovkova, E. and Schegolev, A., 2018. Vascular Endothelial Growth Factor and its Receptors in the Placenta of Gravidas with Obesity. Research Journal of Pharmacy and Technology, 11(3): pp.1153-1158.
8. Bozaoglu, K. et al., 2007. Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome. Endocrinology, 148(10): pp.4687-4694.
9. Dong, B., Ji, W. and Zhang, Y., 2011. Elevated serum chemerin levels are associated with the presence of coronary artery disease in patients with metabolic syndrome. Internal Medicine, 50(10): pp.1093-1097.
10. Doraiswamy, H. and Kirshnamurthy, V., 2015. Cinnamaldehyde Inhibits Visceral Fat Accumulation and the levels of Glucose, Insulin, Leptin in Serum of rats fed with High Fat Diet (HFD). Research Journal of Pharmacy and Technology, 8(12): pp.1701-1706.
11. Fatima, S.S. et al., 2013. Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes. PloS One, 8(2): p.e57113.
12. Fuentes, E. et al., 2013. Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome. Mediators of Inflammation, 2013.
13. Ghasemi, A. et al., 2015. Cut-off points of homeostasis model assessment of insulin resistance, beta-cell function, and fasting serum insulin to identify future type 2 diabetes: Tehran Lipid and Glucose Study. Acta Diabetologica, 52(5), pp.905–915.
14. Goralski, K.B. et al., 2007. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. Journal of Biological Chemistry, 282(38): pp.28175-28188.
15. Jialal, I. et al., 2013. Increased chemerin and decreased omentin-1 in both adipose tissue and plasma in nascent metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism, 98(3): pp. E514–E517.
16. Khan, M. and Joseph, F., 2014. Adipose tissue and adipokines: the association with and application of adipokines in obesity. Scientifica, 2014.
17. Kohan, L., Movahed, Z. and Tabiee, O., 2014. Association between chemerin rs17173608 polymorphism and obesity in Iranian women. Int J Biosci, 4, pp.166-171.
18. Luan, Y. et al., 2015. Insights into the apoptotic death of immune cells in sepsis. Journal of Interferon and Cytokine Research, 35(1): pp.17-22.
19. Makki, K., Froguel, P. and Wolowczuk, I., 2013. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. International Scholarly Research Notices, 2013.
20. Mohan, M., 2014. The Role of Leptin on Obesity: A Review. Research Journal of Pharmacy and Technology, 7(12): pp.1501-1505.
21. Mohsen, H. et al., 2013. Correlation of serum leptin levels with insulin resistance in Syrian obese patients with type 2 diabetes mellitus. Research Journal of Pharmacy and Technology, 6(10): pp.1149-1151.
22. Monalisa, R., 2015. Role of leptin in obesity. Research Journal of Pharmacy and Technology, 8(8): pp.1073-1076.
23. Omran, D.M. et al., 2018. Relationship between Ghrelin and Leptin with Insulin Resistance in Obese Patients and Non-Obese Individuals. Research Journal of Pharmacy and Technology, 11(1): pp.281-283.
24. Pellegrinelli, V. et al., 2015. Human adipocytes induce inflammation and atrophy in muscle cells during obesity. Diabetes, 64(9): pp.3121-3134.
25. Reshmi, B. and Sethu, G., 2015. A Study on Obesity among Children. Research Journal of Pharmacy and Technology, 8(8): pp.1177–1178.
26. Roman, A.A., Parlee, S.D. and Sinal, C.J., 2012. Chemerin: a potential endocrine link between obesity and type 2 diabetes. Endocrine, 42(2): pp.243–251.
27. Saremi, A. et al., 2010. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian Journal of Sports Medicine, 1(3): p.151.
28. Syauqy, A. et al., 2018. Association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein and neutrophil-to-lymphocyte ratio in middle-aged and older adults with metabolic syndrome in Taiwan: a cross-sectional study. Nutrition Journal, 17(1): p.106.
29. Takahashi, M. et al., 2008. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Letters, 582(5): pp.573-578.
30. Takahashi, M. et al., 2011. Chemerin regulates β-cell function in mice. Scientific Reports, 1, p.123.
31. Takahashi, M. et al., 2012. Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism. Endocrine Journal, p.EJ12-0201.
32. Weisberg, S.P. et al., 2003. Obesity is associated with macrophage accumulation in adipose tissue. The Journal of Clinical Investigation, 112(12): pp.1796-1808.
33. Xu, H. et al., 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. The Journal of Clinical Investigation, 112(12): pp.1821-1830.
34. Ye, J., 2013. Mechanisms of insulin resistance in obesity. Frontiers of Medicine, 7(1): pp.14-24.