Author(s): Moushira Zaki, Sanaa Kamal, Mona Abd Elmotaleb A. Hussein, Hend M. Tawfeek, Mina Wassef Girgiss, Amr MM Ibrahim, Eman R. Youness

Email(s): moushiraz@yahoo.com

DOI: 10.52711/0974-360X.2021.00630   

Address: Moushira Zaki1, Sanaa Kamal1, Mona Abd Elmotaleb A. Hussein2, Hend M. Tawfeek3, Mina Wassef Girgiss4, Amr MM Ibrahim5, Eman R. Youness5
1Biological Anthropology Department, National Research Centre, Giza, Egypt.
2Internal Medicine National Institute of Diabetes and Endocrinology, Cairo, Egypt.
3Internal Medicine Faculty of Medicine, Al-Azhar University- Girls.
4Medical Department, Medical Research Division, National Research Centre, Giza, Egypt.
5Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Background: Chemerin has been newly defined to be released from mature adipocytes and the chemerin concentrations in human serum augmented with obesity. There is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. The aim of this study is to expound the prospective role of chemerin the in inflammation. Also, investigate relation between chemerin and serum lipid, glucose, body fat percentage, and metabolic parameters in obese and lean women with IR. Lymphocytes and neutrophils play a major role in inflammation and comprise the first line of defense against infection. The ratio of absolute neutrophil count to lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR), determined as is a novel inflammatory biomarker utilized as a prognostic factor in numerous diseases Methods: This study was designed to investigate serum chemerin, NLR, and high-sensitive C-reactive protein (hsCRP) levels in 50 obese women with IR and 50 lean healthy women. Results: Obese group had significant higher levels of serum chemerin, NLR, hsCRP levels and metabolic parameters than lean one. Chemerin also correlated positively with NLR inflammatory marker and body mass index (BMI). Neutrophil-to-lymphocyte ratio was related to pro-inflammatory Conclusion: The present study elucidates that chemerin levels are concomitant with obesity and IR and could play a role in the inflammation, having key aspects of metabolic syndrome.


Cite this article:
Moushira Zaki, Sanaa Kamal, Mona Abd Elmotaleb A. Hussein, Hend M. Tawfeek, Mina Wassef Girgiss, Amr MM Ibrahim, Eman R. Youness. Comparative Study of Chemerin and Inflammatory markers between Obese with Insulin Resistance and lean healthy women. Research Journal of Pharmacy and Technology. 2021; 14(7):3647-0. doi: 10.52711/0974-360X.2021.00630

Cite(Electronic):
Moushira Zaki, Sanaa Kamal, Mona Abd Elmotaleb A. Hussein, Hend M. Tawfeek, Mina Wassef Girgiss, Amr MM Ibrahim, Eman R. Youness. Comparative Study of Chemerin and Inflammatory markers between Obese with Insulin Resistance and lean healthy women. Research Journal of Pharmacy and Technology. 2021; 14(7):3647-0. doi: 10.52711/0974-360X.2021.00630   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-27


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