Author(s): Mahitab H. El Bishbishy, Nermeen Kamal Hamza, Hebatallah M. Taher, Dalia A. Elaty Mostafa

Email(s): mahelmy@msa.eun.eg , damostafa@msa.eun.eg , hebatahernk24@gmail.com , doc.nhamza@gmail.com

DOI: 10.52711/0974-360X.2021.00629   

Address: Mahitab H. El Bishbishy1, Nermeen Kamal Hamza2, Hebatallah M. Taher2, Dalia A. Elaty Mostafa3
1Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt.
2Faculty of Dentistry, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt.
3Department of Pharmaceutics, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
To the public majority, teeth whitening and appearance is crucial and affect their esthetic qualities. Despite that, in many cultures, home remedies been employed for teeth whitening, there is dearth of solid scientific evidence regarding their effectiveness. This study was conducted aiming to characterize and formulate some of these remedies and to compare their teeth whitening effect to conventional teeth whitening toothpaste after tooth brushing at one and six months’ intervals. Cocos nucifera L. (Coconut) oil, along with the alcoholic extracts of Salvia officinalis L. (Sage) herb, Curcuma longa L. (Turmeric) rhizomes, Psidium guajava L. (Guava) leaves, Citrus limon L. (Lemon) fruits peels and Fragaria ananassa Duchesne (Strawberry) fruits were separately used to prepare toothpastes. The oil and extracts were subjected to GC and HPLC-MS/MS respectively. The formulated toothpastes were of different colors, smooth in nature, foamability around 10, pH-8.2 and extrudability 95%. The best formulations were of S. officinalis (SO), C. longa (CL) and C. nucifera (CN), therefore, their corresponding toothpastes were further investigated. 20 extracted premolars were selected based on orthodontic reasons, randomly distributed into four groups and evaluated using CIELAB measurement system at base line before brushing T0 and after brushing for one month T1 and six months T2. SO showed color changes (? E > 3.3) which can be easily observed clinically. Therefore, it could be concluded that SO toothpaste was effective in changing the color of dental enamel with results comparable to those of the conventional toothpaste.


Cite this article:
Mahitab H. El Bishbishy, Nermeen Kamal Hamza, Hebatallah M. Taher, Dalia A. Elaty Mostafa. Natural Approaches to Whiten the Dental Enamel Surface Versus the Conventional Approaches. Research Journal of Pharmacy and Technology. 2021; 14(7):3639-6. doi: 10.52711/0974-360X.2021.00629

Cite(Electronic):
Mahitab H. El Bishbishy, Nermeen Kamal Hamza, Hebatallah M. Taher, Dalia A. Elaty Mostafa. Natural Approaches to Whiten the Dental Enamel Surface Versus the Conventional Approaches. Research Journal of Pharmacy and Technology. 2021; 14(7):3639-6. doi: 10.52711/0974-360X.2021.00629   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-26


REFERENCES:
1.    Prasanth M, Ratha S N. Antimicrobial Property of Herbal Toothpastes: An In-Vitro Analysis. Research Journal of Pharmacology and Pharmacodynamics. 2014; 6(1): 30-35
2.    Jagtap AM, Kaulage SR, Kanse SS, Shelke VD, Gavade AS, Vambhurkar GB, Todkar RR, Dange VN. Preparation and Evaluation of Toothpaste. Asian J. Pharm. Ana. 2018; 8(4): 191-194.
3.    Claydon N, Moran J, Bosma ML, Shirodaria S, Addy M, Newcombe R. Clinical study to compare the effectiveness of a test whitening toothpaste with a commercial whitening toothpaste at inhibiting dental stain. Journal of Clinical Periodontology. 2004;31:1088-1091.
4.    Pintado-Palomino K, Vasconcelos CV, Silva RJ, et al. Effect of whitening dentifrices: a double-blind randomized controlled trial. Brazilian Oral Research. 2016; 30(1): e82.
5.    Joiner A, Hopkinson I, Deng Y, Westland S. A review of tooth colour and whiteness. Journal of Dentistry. 2008; 36 Suppl 1:S2-7.
6.    Khan MK, Bokhari SA, Haleem A, et al. Extrinsic stain removal with a toothpowder: A randomized controlled trial. International Journal of Health Sciences. 2014; 8(3): 269-274.
7.    De Menezes M, Turssi CP, Hara AT, Messias DC, Serra MC. Abrasion of eroded root dentine brushed with different toothpastes. Clinical Oral Investigations. 2004; 8(3): 151-155.
8.    Kalliath C, Mukunda A, Pynadath M, Venugopal V, Prethweeraj J. Comparison between the effect of commercially available chemical teeth whitening paste and teeth whitening paste containing ingredients of herbal origin on human enamel. Ayu. 2018;39(2):113-117.
9.    Abidia R, El-Hejazi AA, Azam A, Al-Qhatani S, Al-Mugbel K, AlSulami M. Efficacy of Tooth Whitening Using Natural Products in Vitro. The Saudi Dental Journal. 2019; 31: S26.
10.    Marinova. Total phenolics and total flavonoids in bulgarian fruits and vegetables. Journal of the University of Chemical Technology and Metallurgy. 2005; 40(3): 255-260.
11.    Sharma P. Cosmetics- Formulation, manufacturing and quality control. 4th ed: Vandana Publishing House; 2010.
12.    George D, Bhat SS, Antony B. Comparative evaluation of the antimicrobial efficacy of aloe vera tooth gel and two popular commercial toothpastes: an in vitro study. General dentistry. 2009; 57(3): 238-241.
13.    Singh K, Singh P, Oberoi G. Comparative studies between herbal toothpaste (dantkanti) and non-herbal tooth paste. 2016; 4: 53-56.
14.    Solomon CU. Preliminary phytochemical screening of different solvent extracts of stem bark and roots of Dennettia tripetala G. Baker. Asian Journal of Plant Science and Research. 2013; 3(3): 10-13.
15.    White DJ. Development of an improved whitening dentifrice based upon "stain-specific soft silica" technology. The Journal of Clinical Dentistry. 2001; 12(2): 25-29.
16.    Pisani MX, Bruhn JP, Paranhos HF, Silva-Lovato CH, de Souza RF, Panzeri H. Evaluation of the abrasiveness of dentifrices for complete dentures. Journal of prosthodontics : Official Journal of the American College of Prosthodontists. 2010; 19(5): 369-373.
17.    Tripathi S, Sahu Uk, Meshram J, Kumari R, Tripathi DK, Ajazuddin, Alexander A, Sharma H, Sahu GK. Formulation and characterization of Virgin Coconut Oil Emulsion (VCOE) for treatment of Alzheimer’s disease. Res. J. Pharma. Dosage Forms and Tech. 2018; 10(2): 49-54.
18.    Pandian RS, Noora AT. GC-MS Analysis of Phytochemical Compounds Present in the Leaves of Citrus medica. L. Research J. Pharm. and Tech. 2019; 12(4): 1823-1826.
19.    Nagpal M, Sood S.Role of curcumin in systemic and oral health:An overview. J Nat Sci Biol Med. 2013; 4(1): 3-7.
20.    Beheshti-Rouy M, Azarsina M, Rezaie-Soufi L, Alikhani MY, Roshanaie G, Komaki S. The antibacterial effect of sage extract (Salvia officinalis) mouthwash against Streptococcus mutans in dental plaque: a randomized clinical trial. Iranian Journal of Microbiology. 2015; 7(3): 173-177.
21.    Gautam D, Palkar P, Maule K, Singh S, Sawant G, Kuvalekar C, Rukari T, Jagtap VA. Preparation,Evaluation and Comparison of Herbal toothpaste with marketed Herbal toothpaste. Asian J. Pharm. Tech. 2020; 10(3): 165-169
22.    Waly NE, Aborehab NM, Bishbishy MHE. Chemical fingerprint of Bacopa monnieri L. and Rosmarinus officinalis L. and their neuroprotective activity against Alzheimers disease in rat models putative modulation via cholinergic and monoaminergic pathways. Journal of Medicinal Plants Research. 2019; 13: 252-268.
23.    Vallverdú-Queralt A, Regueiro J, Alvarenga JFR, Martinez-Huelamo M, Leal LN, Lamuela-Raventos RM. Characterization of the phenolic and antioxidant profiles of selected culinary herbs and spices: caraway, turmeric, dill, marjoram and nutmeg. Food Science and Technology. 2015; 35: 189-195.
24.    Bakr RO, El Bishbishy MH. Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt. Revista Brasileira de Farmacognosia. 2016; 26(4): 514-520.
25.    Arivukkarasu R, Rajasekaran A, bin hussain Sh, Ajnas M.Simultaneous detection of Rutin, Quercetin, Gallic acid, Caffeic acid, Ferulic acid, Coumarin, Mangiferin and Catechin in Hepatoprotective commercial herbal formulations by HPTLC technique. Res. J. Pharmacognosy and Phytochem. 2018; 10(1): 59-62.
26.    Lee J, Jung Y, Shin J-H, et al. Secondary metabolite profiling of Curcuma species grown at different locations using GC/TOF and UPLC/Q-TOF MS. Molecules (Basel, Switzerland). 2014; 19(7): 9535-9551.
27.    Elhawary SS, Younis IY, El Bishbishy MH, Khattab AR. LC–MS/MS-based chemometric analysis of phytochemical diversity in 13 Ficus spp. (Moraceae): Correlation to their in vitro antimicrobial and in silico quorum sensing inhibitory activities. Industrial Crops and Products. 2018; 126: 261-271.
28.    28.Isrul M, Juliansyah R, Saleh A, Yuliastri WO, Pusmarani JH, Maulidina WOW. Phytochemical Analysis, Standardization and Cytotoxic Activity of Curcuma aureginosa Extract in Human Breast Cancer (MCF-7) Cell Line.Research J. Pharm. and Tech. 2019; 12(4): 1967-1973
29.    Aborehab NM, El Bishbishy MH, Refaiy A, Waly NE. A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis. BMC Complement Altern Med. 2017; 17(1): 495.
30.    Brito A, Ramirez JE, Areche C, Sepúlveda B, Simirgiotis MJ. HPLC-UV-MS profiles of phenolic compounds and antioxidant activity of fruits from three citrus species consumed in Northern Chile. Molecules (Basel, Switzerland). 2014; 19(11): 17400-17421.
31.    Ezzat SM, El Bishbishy MH, Aborehab NM, et al. Upregulation of MC4R and PPAR-α expression mediates the anti-obesity activity of Moringa oleifera Lam. in high-fat diet-induced obesity in rats. Journal of Ethnopharmacology. 2020; 251: 112541.
32.    Wojakowska A, Piasecka A, García-López PM, et al. Structural analysis and profiling of phenolic secondary metabolites of Mexican lupine species using LC–MS techniques. Phytochemistry. 2013; 92: 71-86.
33.    Ibrahim RM, El-Halawany AM, Saleh DO, El Naggar EMB, El-Shabrawy AE-RO, El-Hawary SS. HPLC-DAD-MS/MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic activities. Revista Brasileira de Farmacognosia. 2015; 25: 134-141.
34.    Wang Y, Yang L, He Y-Q, et al. Characterization of fifty-one flavonoids in a Chinese herbal prescription Longdan Xiegan Decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection. Rapid Communications in Mass Spectrometry. 2008; 22(12): 1767-1778.
35.    Subramanian G, Meyyanathan SN, Gowramma B, Palanisamy DS. Liquid chromatography-mass spectrometric method for simultaneous estimation of apigenin and luteolin from Achillea millefolium Linn. Asian J. Research Chem. 2016; 9(12): 629-632.
36.    Simirgiotis MJ, Benites J, Areche C, Sepúlveda B. Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS. Molecules (Basel, Switzerland). 2015; 20(6): 11490-11507.
37.    Kajdzanoska M, Petreska J, Stefova M. Comparison of different extraction solvent mixtures for characterization of phenolic compounds in strawberries. J Agric Food Chem. 2011; 59(10): 5272-5278.
38.    Prakash O, Mahapatra DK, Singh R, Singh N, Verma N, Akash V. Development of a New Isolation Technique and Validated RP-HPLCmethod for Quercetin and Kaempferol from Azadirachta indica leaves. Asian J. Pharm. Ana. 2018; 8(3): 164-168.
39.    El Bishbishy MH, Gad HA, Aborehab NM. Chemometric discrimination of three Pistacia species via their metabolic profiling and their possible in vitro effects on memory functions. Journal of Pharmaceutical and Biomedical Analysis. 2020; 177: 112840.
40.    Mullen W, Yokota T, Lean ME, Crozier A. Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC-MSn. Phytochemistry. 2003; 64(2): 617-624.
41.    Singh RK, Chang HW, Yan D, et al. Influence of diet on the gut microbiome and implications for human health. Journal of Translational Medicine. 2017; 15(1): 73.
42.    Vardhan MS, Krishna KVVS, Sankar KG, Krishna SR, Mani TT. Simultaneous Estimation of Ellagic acid and Quercetin in Marketed Ayurvedic Formulations by HPTLC.Res. J. Pharmacognosy and Phytochem. 2017; 9(4): 223-227

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