Author(s): NF Zolkiflee, MMR Meor Mohd Affandi, ABA Majeed

Email(s): meor@uitm.edu.my

DOI: 10.52711/0974-360X.2021.00628   

Address: NF Zolkiflee1, MMR Meor Mohd Affandi1,3*, ABA Majeed2,3
1Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
2Brain Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
3Pharmaceutical and Life Sciences CoRe, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
In this study, the solute-cosolute interaction, solute-solvent interaction involved in the solubilisation process of ARG solutions and LVS-ARG solution systems are illustrated. The sound velocity values of both solution systems were determined at varying concentrations of ARG (0.01-0.8 mol.dm-3) at 298.15 K. Next, the refractive index and the density of the solution systems was measured at temperature range from 298.15 to 313.15K. Acoustic and volumetric parameters such as isentropic compressibility (KS), apparent isentropic molar compressibility (KSF), relative association (RA), acoustic impedance (Z), internal pressure (pi), free volume (Vf), molar volume (Fv0), molar expansibility (FE0) were calculated from sound velocity and density data. From the study, an increasing trend in sound velocity was observed with the increase in ARG concentration while compressibility values showed opposite trend. Additionally, solute-solvent interaction and structural effects of water for ARG and LVS-ARG systems are discussed regarding the changes in acoustic parameters.


Cite this article:
NF Zolkiflee, MMR Meor Mohd Affandi, ABA Majeed. Solvodynamic study on Solubility Enhanced Lovastatin in presence of Arginine as Cosolute. Research Journal of Pharmacy and Technology. 2021; 14(7):3631-8. doi: 10.52711/0974-360X.2021.00628

Cite(Electronic):
NF Zolkiflee, MMR Meor Mohd Affandi, ABA Majeed. Solvodynamic study on Solubility Enhanced Lovastatin in presence of Arginine as Cosolute. Research Journal of Pharmacy and Technology. 2021; 14(7):3631-8. doi: 10.52711/0974-360X.2021.00628   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-25


REFERENCES:
1.    Jitendra Kumar P, Indira Muzib Y, Misra G. Formulation and Evaluation of Pulsatile Drug Delivery of Lovastatin. Research Journal of Pharmacy and Technology. 2018; 11: 2797-2803.
2.    Nanjwade BK, Derkar GK, Bechra HM, Nanjwade VK, Manvi FV. Design and Characterization of Nanocrystals of Lovastatin for Solubility and Dissolution Enhancement. Journal of Nanomedicine & Nanotechnology. 2011; 2: 1–7.
3.    Sahoo AC, Kanungo SK, Dinda SC, Dash S, Pani S. Formulation Development of Immediate Release Solid Dispersion Tablets of Lovastatin with Enhanced Dissolution. Research Journal of Pharmacy and Technology. 2019; 12: 4963-4972.
4.    Shailendra Gurav SW. LC-ESI-MS/MS method for Quantitation of Lovastatin Liver Homogenate: Application to Pharmacokinetic Study. Asian Journal of Research in Chemistry. 2014; 7: 870-876.
5.    Punitha S, Kumar KLS. Statin Therapy and Their Formulation Approaches: A Review. International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3: 23-26.
6.    Appleton J. Arginine: Clinical potential of a semi-essential amino. Alternative Medicine Review. 2002; 7: 512-522.
7.    Shinde AJ, More HN. Lovastatin Loaded Chitosan Nanoparticles: Preparation, Evaluation and In Vitro Release Studies. Research Journal of Pharmacy and Technology. 2011; 4: 1869-1876.
8.    Panda S, Satpathy M, Mohanty P. Metal Catalyzed Oxidation of L-Arginine by Alkaline KMnO 4 : A Kinetic and Mechanistic Study. Research Journal of Science and Technology. 2015; 7: 230-233
9.    Arakawa T, Kita Y, Koyama AH. Solubility Enhancement of Gluten and Organic Compounds by Arginine. International Journal of Pharmaceutics. 2008; 355: 220-223.
10.    Arakawa T, Tsumoto K, Nagase K, Ejima D. The Effects of Arginine on Protein Binding and Elution in Hydrophobic Interaction and Ion-Exchange Chromatography. Protein Expression and Purification. 2007; 54: 110-116.
11.    Shikiya Y, Tomita S, Arakawa T, Shiraki K. Arginine Inhibits Adsorption of Proteins on Polystyrene Surface. PLoS One. 2013; 8: 1-7.
12.    Malpani A, Raju SA, Hiremath SN. Improved Dissolution Characteristics of Lovastatin by Inclusion in β-CD and Hp β-CD. Research Journal of Pharmacy and Technology. 2009: 2; 110-113.
13.    Kumar R, Debnath S, Ganesh G, Raju L, Samantha M, Suresh B. Chitosan Nano Particles by Ionotropic Gelation Containing L-Arginine. Research Journal of Pharmacy and Technology. 2009; 2: 80-85.
14.    Zolkiflee NF, Meor Mohd Affandi MMR, Majeed ABA. Thermodynamics and Solute-Solvent Interactions of Lovastatin in an Aqueous Arginine Solution. European Journal of Pharmaceutical Sciences. 2020; 141: 1-6.
15.    Higuchi T, Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation. 1965; 4: 117-212.
16.    Savaroglu A, Ceren İldaser. Volumetric and Acoustic Studies of L-tyrosine+L-glutamic Acid+Water at Different Temperatures. Thermochima Acta. 2014; 582: 86-93.
17.    Ali A, Hyder S, Sabir S, Chand D, Nain AK. Volumetric, Viscometric, and Refractive Index Behaviour of α-Amino Acids and Their Groups’ Contribution in Aqueous D-Glucose Solution at Different Temperatures. Journal of Chemical Thermodynamics. 2006; 38: 136-143.
18.    Ahad A, Shafique M, Paradhan V, Farooqui M. Refractive Index Measurements of Liquid Mixtures: A Mini Review. Asian Journal of Research in Chemistry. 2012; 5: 1300-1302.
19.    Dash UN, Roy GS, Mohanty S, Ray M. Thermo-Acoustic Study of Cobalt (III) Complexes in Aqueous and Binary Aqueous Media. Indian Journal of Pure and Applied Physics. 2007; 45: 151-156.
20.    Das S, Dash U. Acoustic Parameters of Glycine, α-Alanine and β-Alanine in Aqueous and Aqueous D-Glucose Solutions at 298.15 K. Asian Journal of Research in Chemistry. 2012; 5: 53-56.
21.    Pattnaik S, Dash UN. Acoustic Parameters of Glycine in Aqueous Solutions of Hydrotropic Agents at 298. 15K. Asian Journal of Research in Chemistry. 2013; 6: 64-67.
22.    Abdullah SB, Man Z, Ismail L, Mutalib MIA, Bustam M.A.. Solubility Parameters Based on Refractive Index Data of Ionic Liquid. Advanced Materials Research. 2014; 917: 45-55.
23.    Ali A, Nabi F, Itoo FA, Tasneem S. Volumetric, Ultrasonic, Viscometric and Refractive Index Behaviour of Binary Mixtures of Styrene with Ethylalcohol and Chlorobenzene at Different Temperatures (T=298.15 K to 313.15 K). Journal of Molecular Liquids. 2008; 143: 141-146.
24.    Rocha Pinto R, Santos D, Mattedi S, Aznar M. Density, Refractive Index, Apparent Volumes and Excess Molar Volumes of Four Protic Ionic Liquids + Water at T=298.15 and 323.15 K. Brazilian Journal of Chemical Engineering. 2015; 32: 671-682.
25.    Kalaskar MM, Hedaoo DS, Wadekar MP. Study of Acoustical Parameters of Substituted Aminopyrimidine by Ultrasonic Technique. Advances in Applied Sciences Research. 2015; 6: 84-88.
26.    Idoux JP, Mc Curry CK, Aminabhavi TM. Densities, Viscosities, Speeds of Sound, and Water Solubilities of Some Polypropylene Glycol Ether Derivatives in the Temperature Range 273.15-323.15 K. Journal of Chemical & Engineering Data. 1994; 39: 261-265.
27.    Bahadur I, Deenadayalu N. Apparent Molar Volume and Isentropic Compressibility for the Binary Systems {Methyltrioctylammonium Bis(trifluoromethylsulfonyl)imide + Methyl Acetate or Methanol} and (Methanol + Methyl Acetate) at T=298.15, 303.15, 308.15 and 313.15 K and Atmospheric Pr. Journal of Solution Chemistry. 2011; 40: 1528-1543.
28.    Srivastava SP, Laxmi S. Ultrasonic Studies of Amino Acids*. Zeitschrift für Physikalische Chemie. 1970; 70: 219-223.
29.    Naseem B, Iftikhar M. Investigation on Molecular Interactions of Antibiotics in Alcohols Using Volumetric and Acoustic Studies at Different Temperatures. The Journal of Chemical Thermodynamics. 2017; 104: 239-251.
30.    Meor Mohd Affadi MMR, Tripathy M, Majeed ABA. Solubility Enhancement of Simvastatin and Atorvastatin by Arginine: A Solvodynamics Study. Journal of Molecular Liquids. 2017; 241: 359-366.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available