The present study was aimed to integrate the developed and optimized ketotifen fumarate dispersion into Orodispersible tablets formulations, to enhance the dissolution rate and bioavailability aspects of the drug. Ketotifen fumarate solid dispersion was prepared using different concentrations of poloxamer 407via solvent evaporation and fusion method. Solubility study, x-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and other investigations were done. Ten formulations of the optimum dispersed ketotifen fumarate Orodispersible tablets were prepared with various superdisintegrants, the results of in vitro - in vivo tests revealed that, the dispersion of the drug in the polymer considerably enhanced the solubility, the batch (Fsd 3) prepared by fusion method showed increased the solubility as ~2-fold compared with a pure drug. FTIR spectra, SEM and XRD data, showed amorphrization of ketotifen fumarate, which explains the better dissolution rate of the drug from its solid dispersions. Formulation F1 containing 15%w/w of crospovidone was showed in vitro- in vivo disintegration time (17 sec., 15 sec. respectively) and percent of drug dissolved in 2 min. was 90.04%, proved to be the optimum formulation, which is required for obtaining rapidly disintegrating tablets. The solubility of the drug had increased, and the resultant orodispersible tablets can be considered as a promising dosage form to achieve better patient compliance.
Cite this article:
Zeina D Salman. Optimization and Evaluation of Orodispersible Solid Dispersion Tablet of Ketotifen Fumarate. Research Journal of Pharmacy and Technology. 2021; 14(7):3610-3616. doi: 10.52711/0974-360X.2021.00624
Zeina D Salman. Optimization and Evaluation of Orodispersible Solid Dispersion Tablet of Ketotifen Fumarate. Research Journal of Pharmacy and Technology. 2021; 14(7):3610-3616. doi: 10.52711/0974-360X.2021.00624 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-21
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