Tanu Srivastava, S. K. Mishra, O. P. Tiwari, Kavindra Nath Tiwari, Pradeep Kumar, Jitendra Kumar, Amit Kumar Singh, Angaraj Singh, Ashutosh Dwivedi
Tanu Srivastava1*, S. K. Mishra2, O. P. Tiwari3, Kavindra Nath Tiwari4, Pradeep Kumar4, Jitendra Kumar2, Amit Kumar Singh2, Angaraj Singh5, Ashutosh Dwivedi5
1Assistant Professor, SHEAT College of Pharmacy, Varanasi, Uttar Pradesh - 221210, India.
2Assistant Professor, Department of Pharmaceutical, Engineering, and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh - 221005, India.
3Director, Varanasi College of Pharmacy, Varanasi, Uttar Pradesh - 221105, India.
4Professor, Department of Botany, MMV, Banaras Hindu University, Varanasi, Uttar Pradesh - 221005, India.
5Assistant Professor, Department of Ceramic Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh -221005, India.
Volume - 14,
Issue - 7,
Year - 2021
Green synthesis of two coordination complexes of zinc acetate with N^N moiety on quercetin, which is a flavonoid is carried out. The complexes were obtained in high yields (> 97%) by grinding methods without the involvement of any solvent. Neither catalyst nor any additives were needed to perform the reactions. It was characterized by FT-IR, UV-Vis, NMR, HRMS, and elemental analysis. Antioxidant activity was done through the DPPH method which was compared with ascorbic acid and ligand (Quercetin). The study reveals that Complex 1 (IC50 163.093µg/ml) has significant free radical scavenging activity as compared to complex 2 (IC50 258.683µg/ml). Biological activity was performed against microbes (E. coli and S. aureus). MIC value of complex 1 (15.50µg/ml E. coli, 7.18µg/ml S. aureus) was found more significant as compared to complex 2 (22.51µg/ml E. coli, 18.62µg/ml S. aureus) and quercetin.
Cite this article:
Tanu Srivastava, S. K. Mishra, O. P. Tiwari, Kavindra Nath Tiwari, Pradeep Kumar, Jitendra Kumar, Amit Kumar Singh, Angaraj Singh, Ashutosh Dwivedi. Green synthesis, Characterization and In vitro Biological Studies of Quercetin complexes with Zn (II) Acetate and N^N Moiety. Research Journal of Pharmacy and Technology. 2021; 14(7):3585-0. doi: 10.52711/0974-360X.2021.00620
Tanu Srivastava, S. K. Mishra, O. P. Tiwari, Kavindra Nath Tiwari, Pradeep Kumar, Jitendra Kumar, Amit Kumar Singh, Angaraj Singh, Ashutosh Dwivedi. Green synthesis, Characterization and In vitro Biological Studies of Quercetin complexes with Zn (II) Acetate and N^N Moiety. Research Journal of Pharmacy and Technology. 2021; 14(7):3585-0. doi: 10.52711/0974-360X.2021.00620 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-17
1. Byeongno Lee, et al. Solid-state and solvent-free synthesis of azines, pyrazoles, and pyridazinones using solid hydrazine. Tetrahedron Letters, 2013; 54: 1384–1388.
2. Chattopadhyay G, PS Ray. A facile method for the conversion of semicarbazone/thiosemicarbazones into azines (under microwave irradiation) and oxadiazoles (by grinding). Synth. Commun. 2011; 41: 2607.
3. Mendiguchia BS, I Aiello, et al. Zn (II) and Cu (II) complexes containing bioactive O, O-chelated ligands: homoleptic and heteroleptic metal-based biomolecules, Dalton Trans. 2015; 44: 9321-9687.
4. Hirohama T, Kuranuki Y, et al. Complex (II) complexes of 1, 10- phenanthroline derived ligand studies on DNA binding properties and nuclease activity. J. Inorg. Biochem. 2005; 99: 1205–1219.
5. Liu HK, Sadler J. Metal complexes as DNA intercalators. Acc. Chem. Res. 2011; 44: 349-359.
6. Liguori PF, Valentini A. Non-classical anticancer agents: synthesis and biological evaluation of zinc (II) heteroleptic complexes. Dalton Trans. 2010; 39: 4205–4212.
7. Filho JCC, Sarria ALF, et al. 2014. PLoS ONE 9 e107058.
8. Pucci D, Crispini A, et al. Improving the bioactivity of Zn (II)-curcumin based complexes. Dalton Trans. De Bartolo. 2013; 42: 9679–9687.
9. Arivukkarasu Ramasamy, Rajasekaran Aiyalu, Kankaria Vishal, Selvam Madesh. In vitro Anti-Cancer Activity and detection of Quercetin, Apigenin in Methanol extract of Euphorbia nivulia Buch. - Ham. By HPTLC technique. Research J. Pharm. And Tech. 2017; 10(8): 2637- 2640. Doi: 10.5958/0974-360X.2017.00468.1.
10. Tanavade Sangeeta S, Smt. Nilofer Naikwade, Dhanyakumar D. Chougule. In vitro anticancer activity of Ethanolic and Aqueous Extracts of Peristrophe bivalvis Merrill. Research J. Pharm. and Tech. 2012; 5(10): 1324-1327.
11. Chakraborty Prithviraj, Kumar Suresh, Dutta Debarupa, Gupta Vikas. Role of Antioxidants in Common Health Diseases. Research J. Pharm. and Tech. 2009; 2 (2): 238-244.
12. Soni Anjali, Femida Patel, Sharma Preeti. In-vitro Cytotoxic Activity of Plant Saponin Extracts on Breast Cancer Cell-Line. Res. J. Pharmacognosy and Phytochem. 2017; 9(1): 17-22.
13. Zouari Ahmed Rachida, Ouahrani M Ridha, Laouini S Eddine, Meneceur Souhaila. Screening of phenolic compounds from Abelmoschus esculentus L extract fruits and In vitro Evaluation of Antioxidant and Antibacterial Activities. Research J. Pharm. and Tech 2017; 10(12): 4371-4376. DOI: 10.5958/0974-360X.2017.00804.6
14. Ranjitha Dhevi V. Sundar, Mythili Sathiavelu. A Comparative Study on Phytochemical Screening, Antioxidant and Antimicrobial Capacities of Leaf Extracts from Medicinal plants. Research J. Pharm. and Tech 2019; 12(1): 361-366. DOI: 10.5958/0974-360X.2019.00066.0
15. Thennarasu A, Quercetin in Health and Disease. Research J. Pharm. and Tech. 6(12): 2013; 1397-1399.
16. Andelescu AA, Cretu C, et al. New heteroleptic Zn (II) and Cu (II) complexes with quercetin and N^N ligands. Polyhedron. 2018; DOI: https://doi.org/10.1016/j.poly.2018.03.016.
17. Kambe T, Tsuji T, et al. The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. Physiol. Rev. 2015; 95:749–784.
18. Pucci D, Crispini A, et al. Improving the bioactivity of Zn (II)-curcumin based complexes. Dalton Trans. 2013; DOI: 10.1039/c3dt50513h.
19. Brand-Williams W, Cuvelier M.E, et al. Use of a Free Radical Method to Evaluate Antioxidant Activity. Lebensm.-Wiss. U.-Technol. 1995; 28: 25–30.
20. Balouiri Mounyr, et al. A method for in-vitro evaluating antimicrobial activity: A review. Journal of pharmaceutical analysis. 2006; 6:71-79.
21. Granato M, Rizzello C, et al. Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways. J. Nutr. Biochem. 2017; 41: 124-136.
22. Handorea Kalpana, Bhavsara Sanjay, et al. Novel Green Route of Synthesis of ZnO Nanoparticles by Using Natural Biodegradable Polymer and Its Application as a Catalyst for Oxidation of Aldehydes. Journal of Macromolecular Science. 2014; 51: 941–947.
23. Kumar Rahul, Bhargava Parag, et al. Synthesis and Characterization of a New Cadmium Complex, Cadmium [(1, 10-phenanthroline) (8-hydroxyquinoline)] Cd (Phen). Procedia Materials Science. 2015; 10: 37 – 43.