Author(s): Tanu Srivastava, S. K. Mishra, O. P. Tiwari, Kavindra Nath Tiwari, Pradeep Kumar, Jitendra Kumar, Amit Kumar Singh, Angaraj Singh, Ashutosh Dwivedi

Email(s): tanusrivns@gmail.com

DOI: 10.52711/0974-360X.2021.00620   

Address: Tanu Srivastava1*, S. K. Mishra2, O. P. Tiwari3, Kavindra Nath Tiwari4, Pradeep Kumar4, Jitendra Kumar2, Amit Kumar Singh2, Angaraj Singh5, Ashutosh Dwivedi5
1Assistant Professor, SHEAT College of Pharmacy, Varanasi, Uttar Pradesh - 221210, India.
2Assistant Professor, Department of Pharmaceutical, Engineering, and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh - 221005, India.
3Director, Varanasi College of Pharmacy, Varanasi, Uttar Pradesh - 221105, India.
4Professor, Department of Botany, MMV, Banaras Hindu University, Varanasi, Uttar Pradesh - 221005, India.
5Assistant Professor, Department of Ceramic Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh -221005, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Green synthesis of two coordination complexes of zinc acetate with N^N moiety on quercetin, which is a flavonoid is carried out. The complexes were obtained in high yields (> 97%) by grinding methods without the involvement of any solvent. Neither catalyst nor any additives were needed to perform the reactions. It was characterized by FT-IR, UV-Vis, NMR, HRMS, and elemental analysis. Antioxidant activity was done through the DPPH method which was compared with ascorbic acid and ligand (Quercetin). The study reveals that Complex 1 (IC50 163.093µg/ml) has significant free radical scavenging activity as compared to complex 2 (IC50 258.683µg/ml). Biological activity was performed against microbes (E. coli and S. aureus). MIC value of complex 1 (15.50µg/ml E. coli, 7.18µg/ml S. aureus) was found more significant as compared to complex 2 (22.51µg/ml E. coli, 18.62µg/ml S. aureus) and quercetin.


Cite this article:
Tanu Srivastava, S. K. Mishra, O. P. Tiwari, Kavindra Nath Tiwari, Pradeep Kumar, Jitendra Kumar, Amit Kumar Singh, Angaraj Singh, Ashutosh Dwivedi. Green synthesis, Characterization and In vitro Biological Studies of Quercetin complexes with Zn (II) Acetate and N^N Moiety. Research Journal of Pharmacy and Technology. 2021; 14(7):3585-0. doi: 10.52711/0974-360X.2021.00620

Cite(Electronic):
Tanu Srivastava, S. K. Mishra, O. P. Tiwari, Kavindra Nath Tiwari, Pradeep Kumar, Jitendra Kumar, Amit Kumar Singh, Angaraj Singh, Ashutosh Dwivedi. Green synthesis, Characterization and In vitro Biological Studies of Quercetin complexes with Zn (II) Acetate and N^N Moiety. Research Journal of Pharmacy and Technology. 2021; 14(7):3585-0. doi: 10.52711/0974-360X.2021.00620   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-17


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