Author(s): Hilya N. Imtihani, Silfiana N. Permatasari, Fitria A. Thalib

Email(s): hilya.imtihani@gmail.com

DOI: 10.52711/0974-360X.2021.00616   

Address: Hilya N. Imtihani*, Silfiana N. Permatasari, Fitria A. Thalib
Surabaya Pharmacy Academy, Surabaya, 60232, Indonesia. *Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
This study aims at evaluating the characteristics of chitosan solid dispersion from whiteleg shrimp (Litopenaeus vannamei). As anti-cholesterol agent, chitosan requires solubility enhancement which can be facilitated in solid dispersion. Here, chitosan solid dispersion was made by solvent evaporation technique used HPMC and PVP K-30 as the carriers, in which the chitosan was prepared from whitleg shrimp shell Chitosan solid dispersion was varied into six formulation, i.e. chitosan: HPMC = FH1 (1:0.25), FH2 (1:0,5), FH3 (1:2), and chitosan: PVP K-30 = FP1 (1:1), FP2 (1:2), and FP3 (1:3), and pristine chitosan, HPMC, and PVP K-30 were utilized as reference compound. Characteristics of chitosan solid dispersion were assessed from the solubility test, SEM, XRD, and FTIR. The result indicates that solubility of chitosan solid dispersion was better than the pristine chitosan. The recommended formula from this study was FP3, because obtained smaller particle size than the other, that could increase the solubility of chitosan. The crystallinity of chitosan remained unchanged upon solid dispersion preparation.


Cite this article:
Hilya N. Imtihani, Silfiana N. Permatasari, Fitria A. Thalib. Solid Dispersion Characteristics of Whiteleg Shrimp (Litopenaeus vannamei) Extracted Chitosan with HPMC and PVP K-30 as Anti-cholesterol Agents. Research Journal of Pharmacy and Technology. 2021; 14(7):3559-5. doi: 10.52711/0974-360X.2021.00616

Cite(Electronic):
Hilya N. Imtihani, Silfiana N. Permatasari, Fitria A. Thalib. Solid Dispersion Characteristics of Whiteleg Shrimp (Litopenaeus vannamei) Extracted Chitosan with HPMC and PVP K-30 as Anti-cholesterol Agents. Research Journal of Pharmacy and Technology. 2021; 14(7):3559-5. doi: 10.52711/0974-360X.2021.00616   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-13


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