Author(s): Aamir Malik, Rakhi Mishra, Rupa Mazumder, Avijit Mazumder, Prem Shankar Mishra


DOI: 10.52711/0974-360X.2021.00595   

Address: Aamir Malik1, Rakhi Mishra1*, Rupa Mazumder1, Avijit Mazumder1, Prem Shankar Mishra2
1Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida-201306, Uttar Pradesh, India.
2Galgotias University, Greater Noida-201306, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021

Pyridazine and its derivative are very important compounds in nitrogen containing heterocyclic compounds due to their various reported pharmacological activities such as antibacterial, muscle relaxant, anti-depressant, antidiabetic, anti-hypertensive, analgesic, anti-tumor, antiviral, nephrotropic, antiinflammatory, anti-viral, anticancer, anti-aggregative, anti-epileptic. It also serves as building block in structure of many chemical constituent of natural compounds phytopharmaceuticals such as cinnolines, phthalazines and also attracting the interest of researchers and medicinal chemist due to its privilege structure which can bear substitution/functionalization easily. Different substituted pyridazine compounds have been synthesized by researchers using different reagents and diverse synthetic route. However most of the investigations available in literature are directed to its large number of biological activities with very less discussion on its various synthetic schemes yielding different type of its derivatives. With the purpose of focusing more on this lack of recent literature this review focuses on different derivative synthesis by using different reaction schemes. Now-a-days pyridazine is serving as ligand in many known chemical reactions and scaffold for drug discovery and development. The aim of this review paper is to encourage more studies on synthesis of pyridazine derivatives which in future will play a vital role for drug discovery.

Cite this article:
Aamir Malik, Rakhi Mishra, Rupa Mazumder, Avijit Mazumder, Prem Shankar Mishra. A comprehensive study on synthesis and biological activities of Pyridazine Derivatives. Research Journal of Pharmacy and Technology. 2021; 14(6):3423-9. doi: 10.52711/0974-360X.2021.00595

Aamir Malik, Rakhi Mishra, Rupa Mazumder, Avijit Mazumder, Prem Shankar Mishra. A comprehensive study on synthesis and biological activities of Pyridazine Derivatives. Research Journal of Pharmacy and Technology. 2021; 14(6):3423-9. doi: 10.52711/0974-360X.2021.00595   Available on:

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